Protective Effect of Hop Ethyl Acetate Extract on Corticosterone-Induced PC12 and Improvement of Depression-like Behavior in Mice [0.03%]
葎草乙酸乙酯提取物对皮质酮诱导的PC12细胞损伤的保护作用及改善小鼠抑郁样行为
Ziwei Ma,Yuming Yu,Ming Gao et al.
Ziwei Ma et al.
Depression is a common mental disorder. In recent years, more and more attention has been paid to depression and its etiology and pathogenesis. This review aims to explore the neuroprotective and antidepressant effects of hop components. By...
Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters [0.03%]
Catharanthine通过抑制α6-烟碱型乙酰胆碱受体和多巴胺转运蛋白调控纹状体多巴胺传递及尼古丁的 psychomotor效应
Benjamin M Williams,Nathan D Steed,Joel T Woolley et al.
Benjamin M Williams et al.
Iboga alkaloids, also known as coronaridine congeners, have shown promise in the treatment of alcohol and opioid use disorders. The objective of this study was to evaluate the effects of catharanthine and 18-methoxycoronaridine (18-MC) on d...
BDNF- and VEGF-Responsive Stimulus to an NGF Mimic Cyclic Peptide with Copper Ionophore Capability and Ctr1/CCS-Driven Signaling [0.03%]
一种铜离子载体肽，可响应BDNF和VEGF刺激模拟NGF并具有Ctr1/Ccs信号传导功能
Barbara Tomasello,Francesco Bellia,Irina Naletova et al.
Barbara Tomasello et al.
Neurotrophins are a family of growth factors that play a key role in the development and regulation of the functioning of the central nervous system. Their use as drugs is made difficult by their poor stability, cellular permeability, and s...
Synthesis and Functional Evaluation of Synthetic Cannabinoid Receptor Agonists Related to ADB-HEXINACA [0.03%]
与ADB-HEXINACA相关的合成大麻素受体激动剂的合成及功能评价
Eric Sparkes,Axelle Timmerman,Jack W Markham et al.
Eric Sparkes et al.
ADB-HEXINACA has been recently reported as a synthetic cannabinoid receptor agonist (SCRA), one of the largest classes of new psychoactive substances (NPSs). This compound marks the entry of the n-hexyl tail group into the SCRA landscape, w...
Prophylactic Administration of Gut Microbiome Metabolites Abrogated Microglial Activation and Subsequent Neuroinflammation in an Experimental Model of Japanese Encephalitis [0.03%]
日本脑炎实验模型中预防性给予肠道微生物代谢产物可消除小胶质细胞活化和随后的神经炎症
Indira Priya Siva Venkatesh,Atreye Majumdar,Anirban Basu
Indira Priya Siva Venkatesh
Short-chain fatty acids (SCFAs) are gut microbial metabolic derivatives produced during the fermentation of ingested complex carbohydrates. SCFAs have been widely regarded to have a potent anti-inflammatory and neuro-protective role and hav...
Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits [0.03%]
不仅仅是情绪障碍──抑郁症是神经发育性认知障碍吗？重点关注前额叶丘脑环路
Nina Nitzan Soto,Patricia Gaspar,Alberto Bacci
Nina Nitzan Soto
Depression is one of the most burdensome psychiatric disorders, affecting hundreds of millions of people worldwide. The disease is characterized not only by severe emotional and affective impairments, but also by disturbed vegetative and co...
Similar Binding Modes of cGMP Analogues Limit Selectivity in Modulating Retinal CNG Channels via the Cyclic Nucleotide-Binding Domain [0.03%]
环核苷酸结合域通过环核苷酸调节视网膜CNG通道的类似配体结合模式限制了选择性
Palina Pliushcheuskaya,Sandeep Kesh,Emma Kaufmann et al.
Palina Pliushcheuskaya et al.
In treating retinitis pigmentosa, a genetic disorder causing progressive vision loss, selective inhibition of rod cyclic nucleotide-gated (CNG) channels holds promise. Blocking the increased Ca2+-influx in rod photoreceptors through CNG cha...
Resting State Brain Networks under Inverse Agonist versus Complete Knockout of the Cannabinoid Receptor 1 [0.03%]
cannabinoid receptor 1 反激动剂与完全敲除条件下大脑的静息状态网络的改变
Hui Li,Qiong Ye,Da Wang et al.
Hui Li et al.
The cannabinoid receptor 1 (CB1) is famous as the target of Δ9-tetrahydrocannabinol (THC), which is the active ingredient of marijuana. Suppression of CB1 is frequently suggested as a drug target or gene therapy for many conditions (e.g., ...
F S Bahr,M Ricke-Hoch,E Ponimaskin et al.
F S Bahr et al.
Acute myocardial infarction (AMI) is one of the leading causes of death worldwide and treatment costs pose a major burden on the global health care system. Despite the variety of treatment options, individual recovery can be still poor and ...
Neuroprotective Assessment of Betaine against Copper Oxide Nanoparticle-Induced Neurotoxicity in the Brains of Albino Rats: A Histopathological, Neurochemical, and Molecular Investigation [0.03%]
甜菜碱对雪貂铜纳米颗粒诱导的神经毒性作用的神经保护效应评估：组织病理学、神经化学和分子学研究
Asmaa R Hashim,Dina W Bashir,Eman Rashad et al.
Asmaa R Hashim et al.
Copper oxide nanoparticles (CuO-NPs) are commonly used metal oxides. Betaine possesses antioxidant and neuroprotective activities. The current study aimed to investigate the neurotoxic effect of CuO-NPs on rats and the capability of betaine...