The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State [0.03%]
DNAJB6b抑制淀粉样蛋白形成的 ability取决于分子伴侣的聚集状态
Andreas Carlsson,Emil Axell,Cecilia Emanuelsson et al.
Andreas Carlsson et al.
For many chaperones, a propensity to self-assemble correlates with function. The highly efficient amyloid suppressing chaperone DNAJB6b has been reported to oligomerize. A key question is whether the DNAJB6b self-assemblies or their subunit...
Dopaminergic Modulation and Computational ADMET Insights for the Antidepressant-like Effect of N-(3-(Phenylselanyl)prop-2-yn-1-yl)benzamide [0.03%]
用于苯甲酰胺类抗抑郁药物样效应的多巴胺能调节和计算 ADMET 见解
Evelyn Mianes Besckow,Kauane Nayara Bahr Ledebuhr,Camila Simões Pires et al.
Evelyn Mianes Besckow et al.
The compound N-(3-(phenylselanyl)prop-2-yn-1-yl)benzamide (SePB), which combines a selenium atom and a benzamide nucleus in an organic structure, has demonstrated a fast antidepressant-like effect in mice. This action is influenced by the s...
Cyclic-NDGA Effectively Inhibits Human γ-Synuclein Fibrillation, Forms Nontoxic Off-Pathway Species, and Disintegrates Preformed Mature Fibrils [0.03%]
环状-NDGA有效抑制人γ-突触核蛋白纤维化，形成无毒的非经典途径物种，并分解预形成的成熟原纤维
Sneh Lata Singh,Rajiv Bhat
Sneh Lata Singh
Parkinson's disease arises from protein misfolding, aggregation, and fibrillation and is characterized by LB (Lewy body) deposits, which contain the protein α-synuclein (α-syn) as their major component. Another synuclein, γ-synuclein (γ...
14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation [0.03%]
14-3-3τ调节α-突触核蛋白早期寡聚化及淀粉样纤维形成
Gobert Heesink,Maxime C M van den Oetelaar,Slav A Semerdzhiev et al.
Gobert Heesink et al.
The aggregation of α-synuclein (αS) plays a key role in Parkinson's disease (PD) etiology. While the onset of PD is age-related, the cellular quality control system appears to regulate αS aggregation throughout most human life. Intriguin...
Neuromodulatory Focused Ultrasound for Epilepsy: Are Animal Models Useful? [0.03%]
针对癫痫的神经调控聚焦超声：动物模型有用吗？
Po-Chun Chu,Hsiang-Yu Yu,Robert S Fisher et al.
Po-Chun Chu et al.
Ultrasound neuromodulation is a potential alternative therapy for suppressing epileptic discharges. Recently, several human clinical trials have reported promising results from repeated focused ultrasound (FUS) treatments for temporal lobe ...
Formation of Calprotectin Inhibits Amyloid Aggregation of S100A8 and S100A9 Proteins [0.03%]
钙保护蛋白的形成可抑制S100A8和S100A9蛋白的淀粉样蛋白聚集作用
Ieva Baronaitė,Darius Šulskis,Aurimas Kopu Stas et al.
Ieva Baronaitė et al.
Calcium-binding S100A8 and S100A9 proteins play a significant role in various disorders due to their pro-inflammatory functions. Substantially, they are also relevant in neurodegenerative disorders via the delivery of signals for the immune...
Metabolite Study and Structural Authentication for the First-in-Human Use Sphingosine-1-phosphate Receptor 1 Radiotracer [0.03%]
用于人体首次应用的S1P受体放射示踪剂代谢产物研究及结构确证
Lin Qiu,Hao Jiang,Kevin Cho et al.
Lin Qiu et al.
The sphingosine-1-phosphate receptor 1 (S1PR1) radiotracer [11C]CS1P1 has shown promise in proof-of-concept PET imaging of neuroinflammation in multiple sclerosis (MS). Our HPLC radiometabolite analysis of human plasma samples collected dur...
Remote Ischemic Postconditioning-Mediated Neuroprotection against Stroke by Promoting Ketone Body-Induced Ferroptosis Inhibition [0.03%]
远程缺血后处理通过促进酮体诱导的铁死亡抑制来对抗中风的神经保护作用
Lin-Yan Huang,Yi-de Zhang,Yi-Ning Liu et al.
Lin-Yan Huang et al.
Neuronal death resulting from ischemic stroke is the primary cause of adult mortality and disability, and effective neuroprotective agents for poststroke intervention are still lacking. Remote ischemic postconditioning (RIPostC) has demonst...
Heparin-Modified Superparamagnetic Iron Oxide Nanoparticles Suppress Lithium Chloride/Pilocarpine-Induced Temporal Lobe Epilepsy in Rats through Attenuation of Inflammation and Oxidative Stress [0.03%]
肝素修饰的超顺磁性铁氧化纳米颗粒通过抑制炎症和氧化应激来抑制氯化锂/ pilocarpine诱导的大鼠颞叶癫痫发作
Hanbing Xu,Yubo Wang,Congcong Yu et al.
Hanbing Xu et al.
The development of antiepileptic drugs is still a long process. In this study, heparin-modified superparamagnetic iron oxide nanoparticles (UFH-SPIONs) were prepared, and their antiepileptic effect and underlying mechanism were investigated...
4-Amidophenol Quinone Methide Precursors: Effective and Broad-Scope Nonoxime Reactivators of Organophosphorus-Inhibited Cholinesterases and Resurrectors of Organophosphorus-Aged Acetylcholinesterase [0.03%]
4-氨基苯酚醌甲基化前体：有效的广谱非肟类胆碱酯酶再活化剂，可复活老化型有机磷酰化乙酰胆碱酯酶
Alex R Lovins,Kevin A Miller,Anne K Buck et al.
Alex R Lovins et al.
Acetylcholinesterase (AChE) inhibition by organophosphorus (OP) compounds poses a serious health risk to humans. While many therapeutics have been tested for treatment after OP exposure, there is still a need for efficient reactivation agai...