Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes [0.03%]
α7烟碱型乙酰胆碱受体(PICK1)复合物中非传统的PDZ识别模式
Vasyl Bondarenko,Qiang Chen,Tommy S Tillman et al.
Vasyl Bondarenko et al.
PDZ domains are modular domains that conventionally bind to C terminal or internal motifs of target proteins to control cellular functions through the regulation of protein complex assemblies. Almost all reported structures of PDZ-target pr...
Ligand Profiling as a Diagnostic Tool to Differentiate Patient-Derived α-Synuclein Polymorphs [0.03%]
配体分析作为区分患者衍生的α-突触核蛋白多形体的诊断工具
Timothy S Chisholm,Ronald Melki,Christopher A Hunter
Timothy S Chisholm
Amyloid fibrils are characteristic of many neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. While different diseases may have fibrils formed of the same protein, the supramolecular morphology of these fibrils is d...
Donald F Weaver
Donald F Weaver
Although β-amyloid (Aβ) has long been studied as a key contributor to the pathology of Alzheimer's disease (AD), its physiological role (if any) remains undetermined. This Viewpoint highlights the evolving concept that if AD is an immunop...
Chronic Behavioral and Neurochemical Effects of Four Novel N-Benzyl-2-phenylethylamine Derivatives Recently Identified as "Psychoactive" in Adult Zebrafish Screens [0.03%]
四种新型“精神活性”N-苯基乙胺衍生物的慢性行为和神经化学作用的成年斑马鱼筛查中的效应
Nikita P Ilyin,Arslan D Nabiullin,Anna D Kozlova et al.
Nikita P Ilyin et al.
Potently affecting human and animal brain and behavior, hallucinogenic drugs have recently emerged as potentially promising agents in psychopharmacotherapy. Complementing laboratory rodents, the zebrafish (Danio rerio) is a powerful model o...
Correction to "Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo" [0.03%]
“硝基美安新型抗痴呆药的作用机制研究”一文的更正
Shinghung Mak,Zheng Liu,Liangmiao Wu et al.
Shinghung Mak et al.
Published Erratum
ACS chemical neuroscience. 2024 May 15;15(10):2089-2090. DOI:10.1021/acschemneuro.4c00233 2024
Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain [0.03%]
Ran结合蛋白2对小分子热休克伴侣-晶体蛋白的蛋白质稳态重塑及其环素结构域的肽基-脯氨酰顺反异构酶和分子伴侣活性
Hemangi Patil,Haiqing Yi,Kyoung-In Cho et al.
Hemangi Patil et al.
Disturbances in protein phase transitions promote protein aggregation─a neurodegeneration hallmark. The modular Ran-binding protein 2 (Ranbp2) is a cytosolic molecular hub for rate-limiting steps of phase transitions of Ran-GTP-bound prote...
Synthesis and Neuroprotective Evaluation of Substituted Indanone/Benzofuranone and Piperidine Hybrids [0.03%]
取代的茚酮/苯并呋喃酮和哌啶杂合衍生物的合成及其神经保护活性评估
Qing Zeng,Ziwei Zhang,Zhifang Cai et al.
Qing Zeng et al.
Based on the neuroprotection of butylphthalide and donepezil, a series of indanone/benzofuranone and piperidine hybrids were designed and synthesized for assessment of their neuroprotective activities, aiming to enhance the bioavailability ...
Simultaneous Determination of Selected Steroids with Neuroactive Effects in Human Serum by Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry [0.03%]
采用超高效液相色谱-串联质谱法同时测定人血清中具有神经活性的多种甾体化合物
Michal Kaleta,Jana Oklestkova,Kateřina Klíčová et al.
Michal Kaleta et al.
Neuroactive steroids are a group of steroid molecules that are involved in the regulation of functions of the nervous system. The nervous system is not only the site of their action, but their biosynthesis can also occur there. Neuroactive ...
Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and AppNL-F Mice [0.03%]
APP23、APPPS1和AppNL-F小鼠Aβ淀粉样斑块内发散的年龄依赖性构象重排
Farjana Parvin,Samuel Haglund,Bettina Wegenast-Braun et al.
Farjana Parvin et al.
Amyloid plaques composed of fibrils of misfolded Aβ peptides are pathological hallmarks of Alzheimer's disease (AD). Aβ fibrils are polymorphic in their tertiary and quaternary molecular structures. This structural polymorphism may carry ...
Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[ h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases [0.03%]
实用的三组分区域选择性合成潜在的非共价多靶点抑制剂类药物3-芳基(或杂环芳基)-5,6-二氢苯并[h]香豆素用于对抗神经退行性疾病
Hossein Mousavi,Mehdi Rimaz,Behzad Zeynizadeh
Hossein Mousavi
Neurodegenerative diseases (NDs) are one of the prominent health challenges facing contemporary society, and many efforts have been made to overcome and (or) control it. In this research paper, we described a practical one-pot two-step thre...