Ion Dyshomeostasis in the Early Hyperacute Phase after a Temporary Large-Vessel Occlusion Stroke [0.03%]
大血管闭塞性卒中早期 hyperacute 期离子失衡的研究
M Jake Pushie,Nicole J Sylvain,Huishu Hou et al.
M Jake Pushie et al.
Element dysregulation is a pathophysiologic hallmark of ischemic stroke. Prior characterization of post-stroke element dysregulation in the photothrombotic model demonstrated significant element changes for ions that are essential for the f...
Sigma Receptor Ligands Are Potent Antiprion Compounds that Act Independently of Sigma Receptor Binding [0.03%]
sigma受体配体是一类强力抗朊病毒化合物且作用方式独立于sigma受体结合之外
Robert C C Mercer,Nhat T T Le,Douglas G Fraser et al.
Robert C C Mercer et al.
Prion diseases are invariably fatal neurodegenerative diseases of humans and other animals for which there are no effective treatment options. Previous work from our laboratory identified phenethylpiperidines as a novel class of anti-prion ...
Novel Alaninamide Derivatives with Drug-like Potential for Development as Antiseizure and Antinociceptive Therapies─In Vitro and In Vivo Characterization [0.03%]
具有药物潜力的新型胺基衍生物作为抗惊厥和镇痛疗法的发展──体外及体内特征分析
Marcin Jakubiec,Michał Abram,Mirosław Zagaja et al.
Marcin Jakubiec et al.
In the present study, a series of original alaninamide derivatives have been designed applying a combinatorial chemistry approach, synthesized, and characterized in the in vivo and in vitro assays. The obtained molecules showed potent and b...
Mechanistic Insights Behind the Self-Assembly of Human Insulin under the Influence of Surface-Engineered Gold Nanoparticles [0.03%]
表面工程金纳米粒子作用下人胰岛素自我组装的机理研究
Zachary Flint,Haylee Grannemann,Kristos Baffour et al.
Zachary Flint et al.
Elucidating the underlying principles of amyloid protein self-assembly at nanobio interfaces is extremely challenging due to the diversity in physicochemical properties of nanomaterials and their physical interactions with biological system...
2-Butoxytetrahydrofuran, Isolated from Holothuria scabra, Attenuates Aggregative and Oxidative Properties of α-Synuclein and Alleviates Its Toxicity in a Transgenic Caenorhabditis elegans Model of Parkinson's Disease [0.03%]
从霍洛西巴rella提取的2-丁氧基四氢呋喃可减轻α-突触核蛋白聚集性、氧化性和在帕金森病线虫模型中的毒性
Sukrit Promtang,Tanatcha Sanguanphun,Pawanrat Chalorak et al.
Sukrit Promtang et al.
Aggregative α-synuclein and incurring oxidative stress are pivotal cascading events, leading to dopaminergic (DAergic) neuronal loss and contributing to clinical manifestations of Parkinson's disease (PD). Our previous study demonstrated t...
Identifying Substructures That Facilitate Compounds to Penetrate the Blood-Brain Barrier via Passive Transport Using Machine Learning Explainer Models [0.03%]
基于机器学习解释模型识别可帮助化合物通过被动运输穿过血脑屏障的亚结构
Lucca Caiaffa Santos Rosa,Caio Oliveira Argolo,Cayque Monteiro Castro Nascimento et al.
Lucca Caiaffa Santos Rosa et al.
The local interpretable model-agnostic explanation (LIME) method was used to interpret two machine learning models of compounds penetrating the blood-brain barrier. The classification models, Random Forest, ExtraTrees, and Deep Residual Net...
Increased Expression of VCAM1 on Brain Endothelial Cells Drives Blood-Brain Barrier Impairment Following Chronic Cerebral Hypoperfusion [0.03%]
脑低灌注慢性损伤时血管细胞粘附分子VCAM1表达上调诱发血脑屏障破坏
Huiwen Zhang,Junkui Shang,Wei Li et al.
Huiwen Zhang et al.
Chronic cerebral hypoperfusion (CCH)-triggered blood-brain barrier (BBB) dysfunction is a core pathological change occurring in vascular dementia (VD). Despite the recent advances in the exploration of the structural basis of BBB impairment...
Exploring the Interactions between two Ligands, UCB-J and UCB-F, and Synaptic Vesicle Glycoprotein 2 Isoforms [0.03%]
UCB-J和UCB-F与突触囊泡糖蛋白2各异构体之间相互作用的探究
Junhao Li,Rongfeng Zou,Andrea Varrone et al.
Junhao Li et al.
In silico modeling was applied to study the efficiency of two ligands, namely, UCB-J and UCB-F, to bind to isoforms of the synaptic vesicle glycoprotein 2 (SV2) that are involved in the regulation of synaptic function in the nerve terminals...
Parvalbumin Regulates GAD Expression through Calcium Ion Concentration to Affect the Balance of Glu-GABA and Improve KA-Induced Status Epilepticus in PV-Cre Transgenic Mice [0.03%]
钙离子浓度依赖性 parvalbumin 蛋白调节GAD表达影响谷氨酸-氨基丁酸平衡改善PV-Cre转基因小鼠兴奋毒性癫痫状态作用研究
Chunmei Zeng,Yuling Lu,Xing Wei et al.
Chunmei Zeng et al.
Aims: the study aimed to (i) use adeno-associated virus technology to modulate parvalbumin (PV) gene expression, both through overexpression and silencing, within the hippocampus of male mice and (ii) assess the impact of PV on the metaboli...
Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes [0.03%]
α7烟碱型乙酰胆碱受体(PICK1)复合物中非传统的PDZ识别模式
Vasyl Bondarenko,Qiang Chen,Tommy S Tillman et al.
Vasyl Bondarenko et al.
PDZ domains are modular domains that conventionally bind to C terminal or internal motifs of target proteins to control cellular functions through the regulation of protein complex assemblies. Almost all reported structures of PDZ-target pr...