Amyloid Mimicking Assemblies Formed by Glutamine, Glutamic Acid, and Aspartic Acid [0.03%]
由谷氨酰胺、谷氨酸和天冬氨酸形成的类淀粉样多聚体结构簇群
Ankita Jaiswal,Monisha Patel,Anam Naseer et al.
Ankita Jaiswal et al.
The aggregation of amino acids into amyloid-like structures is a critical phenomenon for understanding the pathophysiology of various diseases, including inborn errors of metabolism (IEMs) associated with amino acid imbalances. Previous stu...
Structure-Activity Relationships, Deuteration, and Fluorination of Synthetic Cannabinoid Receptor Agonists Related to AKB48, 5F-AKB-48, and AFUBIATA [0.03%]
与AKB48、5F-AKB-48和AFUBIATA有关的合成大麻素受体激动剂的构效关系、去氢化作用及氟化作用
Eric Sparkes,Callan J Maloney,Jack W Markham et al.
Eric Sparkes et al.
Synthetic cannabinoid receptor agonists (SCRAs) are a growing class of new psychoactive substances (NPS) commonly derived from an N-alkylated indole, indazole, or 7-azaindole scaffold. Diversification of this core (at the 3-position) with a...
RE104: Synthesis and Activity of a Novel Serotonergic Psychedelic Prodrug of 4-Hydroxy- N, N-diisopropyltryptamine [0.03%]
RE104：4-羟-N，N-二异丙基二甲基色胺血清素致幻药前药的合成与活性
Nathan Bryson,Robert Alexander,Aviva Asnis-Alibozek et al.
Nathan Bryson et al.
Results from randomized clinical trials of psilocybin in depressive disorders highlight the therapeutic potential of serotonergic psychedelic compounds in mental health disorders. The synthetic 5-hydroxytryptamine 2A receptor agonist 4-hydr...
Sex-Dimorphic Effects of Hypoglycemia on Metabolic Sensor mRNA Expression in Ventromedial Hypothalamic Nucleus-Dorsomedial Division (VMNdm) Growth Hormone-Releasing Hormone Neurons [0.03%]
下丘脑腹内侧核背内侧区生长激素释放激素神经元的低血糖反应性性别差异：代谢感受器mRNA表达模式不同
Subash Sapkota,Karen P Briski
Subash Sapkota
Growth hormone-releasing hormone (Ghrh) neurons in the dorsomedial ventromedial hypothalamic nucleus (VMNdm) express the metabolic transcription factor steroidogenic factor-1 and hypoglycemia-sensitive neurochemicals of diverse chemical str...
Development of Triphenylmethane Dyes for In Vivo Fluorescence Imaging of Aβ Oligomers [0.03%]
体内荧光成像淀粉样蛋白寡聚体的茋类染料的发展研究
Kotaro Nagashima,Hiroyuki Watanabe,Takahiro Akasaka et al.
Kotaro Nagashima et al.
Detection of amyloid β (Aβ) oligomers, regarded as the most toxic aggregated forms of Aβ, can contribute to the diagnosis and treatment of Alzheimer's disease (AD). Thus, the development of imaging probes for in vivo visualization of Aβ...
Differential Effects of Post-translational Modifications on the Membrane Interaction of Huntingtin Protein [0.03%]
huntingtin蛋白不同翻译后修饰对其膜结合的调控作用机制不同
Zhidian Zhang,Charlotte Gehin,Luciano A Abriata et al.
Zhidian Zhang et al.
Huntington's disease is a neurodegenerative disorder caused by an expanded polyglutamine stretch near the N-terminus of the huntingtin (HTT) protein, rendering the protein more prone to aggregate. The first 17 residues in HTT (Nt17) interac...
First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3β/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer's Disease [0.03%]
治疗阿尔茨海默病的新型非竞争性糖原合酶激酶3β/组蛋白去乙酰酶抑制剂潜在药物研究
Alan Santini,Elisa Tassinari,Eleonora Poeta et al.
Alan Santini et al.
Despite recent FDA approvals, Alzheimer's disease (AD) still represents an unmet medical need. Among the different available therapeutic approaches, the development of multitarget molecules represents one of the most widely pursued. In this...
Gavin R Hoffman,Chetan Giduturi,Nicholas J Cordaro et al.
Gavin R Hoffman et al.
Xylazine (also known as "tranq") is a potent nonopioid veterinary sedative that has recently experienced a surge in use as a drug adulterant, most often combined with illicitly manufactured fentanyl. This combination may heighten the risk o...
Evaluating the Neuroprotective Potential of Novel Benzodioxole Derivatives in Parkinson's Disease via AMPA Receptor Modulation [0.03%]
通过AMPA受体调节评估新型苯并二氧六环衍生物在帕金森病中的神经保护潜力
Mohammed Hawash,Mohammad Qneibi,Hiba Natsheh et al.
Mohammed Hawash et al.
Parkinson's disease (PD) is a significant health issue because it gradually damages the nervous system. α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors play a significant role in the development of PD. The current inv...
(+)-Borneol Protects Dopaminergic Neuronal Loss in Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson's Disease Mice: A Study of Dopamine Level using In Vivo Brain Microdialysis [0.03%]
(+)-薄荷醇通过体内脑微透析技术调节多巴胺水平保护1-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的帕金森病小鼠多巴胺能神经元损伤的作用研究
Lina Ding,Long Wang,Jiaxin Yang et al.
Lina Ding et al.
Considerable research efforts have been directed toward the symptom relief of Parkinson's disease (PD) by attenuating dopamine (DA) depletion. One common feature of these existing therapies is their unavailability of preventing the neurodeg...