Effects of the Synthetic Cathinone α-Pyrrolidinobutiothiophenone (α-PBT) on Discriminative Stimulus Effects and Intracranial Self-Stimulation Thresholds in Male Rats [0.03%]
合成卡西酮α-吡咯烷丁氧硫酚(α-PBT)对雄性大鼠辨别刺激效应和颅内自我刺激阈值的影响
Eun Young Jang,Bong Hyo Lee,Jaesuk Yun et al.
Eun Young Jang et al.
Recently, the abuse of synthetic cathinones is increasing among young people. α-Pyrrolidinobutiothiophenone (α-PBT), a synthetic cathinone, is a designer drug that is freely traded online with no legal restrictions. Moreover, there is cur...
Hydrophobic C-Terminal Peptide Analog Aβ31-41 Protects the Neurons from Aβ-Induced Toxicity [0.03%]
疏水性C端多肽模拟物Aβ31-41可保护神经元免受Aβ诱导的细胞毒性损害
Rathnam Mallesh,Juhee Khan,Prabir Kumar Gharai et al.
Rathnam Mallesh et al.
Spontaneous aggregation of amyloid beta (Aβ) leads to the formation of neurotoxic senile plaque considered as the most crucial event in Alzheimer's disease (AD) progression. Inhibition or disruption of this deadly aggregate formation is on...
Protein Painting Mass Spectrometry in the Discovery of Interaction Sites within the Acetylcholine Binding Protein [0.03%]
乙酰胆碱结合蛋白相互作用位点发现中的蛋白质绘制质谱法
Alexandru Graur,Amanda Haymond,Kyung Hyeon Lee et al.
Alexandru Graur et al.
Nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channel receptors that contribute to cognition, memory, and motor control in many organisms. The pharmacological targeting of these receptors, using small molecules...
In Vitro and In Vivo Investigations of Chromone Derivatives as Potential Multitarget-Directed Ligands: Cognitive Amelioration Utilizing a Scopolamine-Induced Zebrafish Model [0.03%]
体内体外研究黄酮衍生物作为潜在的多靶向导向配体：利用水杨酸诱导斑马鱼模型改善认知能力
Naveen Kumar,Kailash Jangid,Vishal Kumar et al.
Naveen Kumar et al.
Alzheimer's disease is a complex neurological disorder linked with multiple pathological hallmarks. The interrelation of therapeutic targets assists in the enhancement of cognitive decline through interference with overall neuronal transmis...
Oral Administration of a Specific p300/CBP Lysine Acetyltransferase Activator Induces Synaptic Plasticity and Repairs Spinal Cord Injury [0.03%]
口服特异性p300/CBP赖氨酸乙酰转移酶激活剂可诱导突触可塑性并修复脊髓损伤
Akash Kumar Singh,Amrish Rai,Ila Joshi et al.
Akash Kumar Singh et al.
TTK21 is a small-molecule activator of p300/creb binding protein (CBP) acetyltransferase activity, which, upon conjugation with a glucose-derived carbon nanosphere (CSP), can efficiently cross the blood-brain barrier and activate histone ac...
Alexander J Dear,Dev Thacker,Stefan Wennmalm et al.
Alexander J Dear et al.
Oligomeric assemblies consisting of only a few protein subunits are key species in the cytotoxicity of neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. Their lifetime in solution and abundance, governed by the bala...
Menthol-Modified Quercetin Liposomes with Brain-Targeting Function for the Treatment of Senescent Alzheimer's Disease [0.03%]
用于治疗衰老型阿尔茨海默病的薄荷改性山柰酚脂质体的大脑靶向功能研究
Wan-Ying Liu,Yang Yu,Juan Zang et al.
Wan-Ying Liu et al.
Oxidative stress and neuroinflammation in the aging brain are correlated with the development of neurodegenerative diseases, such as Alzheimer's disease (AD). The blood-brain barrier (BBB) poses a significant challenge to the effective deli...
Ying Zhou,Ting Qi,Yuwei Yang et al.
Ying Zhou et al.
Staining frozen sections is often required to distinguish cell types for spatial transcriptomic studies of the brain. The impact of the staining methods on the RNA integrity of the cells becomes one of the limitations of spatial transcripto...
Increased Cerebral Level of P2X7R in a Tauopathy Mouse Model by PET Using [18F]GSK1482160 [0.03%]
tauopathy小鼠模型中P2X7R放射配体[18F]GSK1482160的PET研究
Yanyan Kong,Lei Cao,Jiao Wang et al.
Yanyan Kong et al.
Neuroinflammation plays an important role in Alzheimer's disease and primary tauopathies. The aim of the current study was to map [18F]GSK1482160 for imaging of purinergic P2X7R in Alzheimer's disease and primary tauopathy mouse models. Sma...
Vertebrates on a Chip: Noninvasive Electrical and Optical Mapping of Whole Brain Activity Associated with Pharmacological Treatments [0.03%]
芯片上的脊椎动物：与药物治疗相关的整个大脑活动的非侵入性电学和光学映射
Zhen Liu,Xuan Luo,Richard Yan-Do et al.
Zhen Liu et al.
Mapping brain activities is necessary for understanding brain physiology and discovering new treatments for neurological disorders. Such efforts have greatly benefited from the advancement in technologies for analyzing neural activity with ...