Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A [0.03%]
幻觉剂对功能连接的急性影响：裸盖菇素和鼠柳因-A
Frederick A Bagdasarian,Hanne D Hansen,Jingyuan Chen et al.
Frederick A Bagdasarian et al.
The extent of changes in functional connectivity (FC) within functional networks as a common feature across hallucinogenic drug classes is under-explored. This work utilized fMRI to assess the dissociative hallucinogens Psilocybin, a classi...
Chronic Neuropathic Pain and Comorbid Depression Syndrome: From Neural Circuit Mechanisms to Treatment [0.03%]
慢性神经病理性疼痛及其共患抑郁症：从神经环路机制到治疗
Yue Zhang,Hui Ma,Yafan Bai et al.
Yue Zhang et al.
Chronic neuropathic pain and comorbid depression syndrome (CDS) is a major worldwide health problem that affects the quality of life of patients and imposes a tremendous socioeconomic burden. More than half of patients with chronic neuropat...
Discovery of a CK2α'-Biased ATP-Competitive Inhibitor from a High-Throughput Screen of an Allosteric-Inhibitor-Like Compound Library [0.03%]
一类别构抑制剂类化合物库的高通量筛选发现CK2α'偏向型ATP竞争性抑制剂
Deepti Mudaliar,Rachel H Mansky,Angel White et al.
Deepti Mudaliar et al.
Protein kinase CK2 is a holoenzyme composed of two regulatory subunits (CK2β) and two catalytic subunits (CK2α and CK2α'). CK2 controls several cellular processes, including proliferation, inflammation, and cell death. However, CK2α and...
β-Synuclein Intermediates α-Synuclein Neurotoxicity in Parkinson's Disease [0.03%]
β-突触核蛋白介导α-突触核蛋白在帕金森病中的神经毒性作用
Meiyan Xian,Jingwen Li,Tingting Liu et al.
Meiyan Xian et al.
Parkinson's disease (PD) is the second most common age-related neurodegenerative disease in the world, and synuclein is closely related to the onset and progression of PD. Synuclein is considered a therapeutic target for PD. Recent studies ...
Development of CRID3-Based Anti-inflammatory Agents to Ameliorate Chronic Hypoxia-Induced Memory Impairment in Zebrafish Models [0.03%]
基于CRID3的抗炎剂的开发以改善斑马鱼慢性缺氧模型的记忆力损害
Kalyani Soren,Rakesh K Bollikanda,Tapatee Das et al.
Kalyani Soren et al.
Chronic hypoxic exposure triggers the onset and progression of cognitive dysfunction; however, the mechanisms underlying chronic hypoxia-induced neuroinflammation and its contribution to cognitive dysfunction remain poorly understood. Altho...
Unveiling the Journey from the Gut to the Brain: Decoding Neurodegeneration-Gut Connection in Parkinson's Disease [0.03%]
从肠道到大脑的旅程：帕金森病神经退行性病变与肠道连接机制探索
Kritika Bhardwaj,Aditya A Singh,Hemant Kumar
Kritika Bhardwaj
Parkinson's disease, a classical motor disorder affecting the dopaminergic system of the brain, has been as a disease of the brain, but this classical notion has now been viewed differently as the pathology begins in the gut and then gradua...
Brain Glucose Metabolism as a Readout of the Central Nervous System Impact of Cigarette Smoke Exposure and Withdrawal and the Effects of NFL-101, as an Immune-Based Drug Candidate for Smoking Cessation Therapy [0.03%]
尼古丁免疫疗法候选药物NFL-101对吸烟及戒断诱导的中枢神经系统影响的作用机制研究——基于脑葡萄糖代谢的影像学生物标志物研究
Sébastien Goutal,Thi Tran,Claire Leroy et al.
Sébastien Goutal et al.
Neuroimaging biomarkers are needed to investigate the impact of smoking withdrawal on brain function. NFL-101 is a denicotinized aqueous extract of tobacco leaves currently investigated as an immune-based smoking cessation therapy in humans...
Power of Dopamine: Multifunctional Compound Assisted Conversion of the Most Risk Factor into Therapeutics of Alzheimer's Disease [0.03%]
多巴胺的力量：多功能化合物辅助将阿尔茨海默病最危险因素转化为治疗药物
Prabir Kumar Gharai,Juhee Khan,Krishnangsu Pradhan et al.
Prabir Kumar Gharai et al.
In Alzheimer's disease (AD), reactive oxygen species (ROS) plays a crucial role, which is produced from molecular oxygen with extracellular deposited amyloid-β (Aβ) aggregates through the reduction of a Cu2+ ion. In the presence of a smal...
N-Salicyloyl Tryptamine Derivatives as Potent Neuroinflammation Inhibitors by Constraining Microglia Activation via a STAT3 Pathway [0.03%]
通过STAT3途径限制小胶质细胞活化以抑制神经炎症的N-水杨酰色氨酸衍生物
Yuting Zhao,Yan Peng,Xiuzhen Wei et al.
Yuting Zhao et al.
Neuroinflammation is an important factor that exacerbates neuronal death and abnormal synaptic function in neurodegenerative diseases (NDDs). Due to the complex pathogenesis and the presence of blood-brain barrier (BBB), no effective clinic...
Computer-Aided Design and Biological Evaluation of Diazaspirocyclic D4R Antagonists [0.03%]
基于计算机的Diazaspirocyclic D4受体拮抗剂的设计及生物评估
Caleb A H Jones,Benjamin P Brown,Daniel C Schultz et al.
Caleb A H Jones et al.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra, resulting in motor dysfunction. Current treatments are primarily centered around enhancing dopam...