Mechanistic Insight into Intestinal α-Synuclein Aggregation in Parkinson's Disease Using a Laser-Printed Electrochemical Sensor [0.03%]
用于帕金森病肠道α-突触核蛋白聚集的激光打印电化学传感器研究 механизму]intestinal α-synuclein aggregation in Parkinson's disease using a laser-printed electrochemical sensor
Julia M Balsamo,Keren Zhou,Vinay Kammarchedu et al.
Julia M Balsamo et al.
Aggregated deposits of the protein α-synuclein and depleting levels of dopamine in the brain correlate with Parkinson's disease development. Treatments often focus on replenishing dopamine in the brain; however, the brain might not be the ...
Dopamine Release Dynamics in the Nucleus Accumbens Are Modulated by the Timing of Electrical Stimulation Pulses When Applied to the Medial Forebrain Bundle and Medial Prefrontal Cortex [0.03%]
中脑前束和内侧前额叶皮层电刺激诱发伏隔核多巴胺能神经元脉冲发放的时间依赖性及其对多巴胺动态释放的调制作用研究
Andrea R Hamilton,Abhilasha Vishwanath,Nathan C Weintraub et al.
Andrea R Hamilton et al.
Electrical brain stimulation has been used in vivo and in vitro to investigate neural circuitry. Historically, stimulation parameters such as amplitude, frequency, and pulse width were varied to investigate their effects on neurotransmitter...
A Snake Venom Peptide and Its Derivatives Prevent Aβ42 Aggregation and Eliminate Toxic Aβ42 Aggregates In Vitro [0.03%]
一种蛇毒多肽及其衍生物可预防并消除体外Aβ42毒性聚集体
Luana Cristina Camargo,Ian Gering,Mohammadamin Mastalipour et al.
Luana Cristina Camargo et al.
Over a century has passed since Alois Alzheimer first described Alzheimer's disease (AD), and since then, researchers have made significant strides in understanding its pathology. One key feature of AD is the presence of amyloid-β (Aβ) pe...
Astrocyte Mitochondria Are a Sensitive Target of PCB52 and its Human-Relevant Metabolites [0.03%]
多氯联苯52及其人体相关代谢产物对星形胶质细胞线粒体的敏感影响
Neha Paranjape,Stefan Strack,Hans-Joachim Lehmler et al.
Neha Paranjape et al.
Polychlorinated biphenyls (PCBs) are industrial chemicals that are ubiquitously found in the environment. Exposure to these compounds has been associated with neurotoxic outcomes; however, the underlying mechanisms for such outcomes remain ...
A Novel Analog of the Natural Product Fraxinellone Protects against Endogenous and Exogenous Neurotoxicants [0.03%]
一类天然产物小分子化合物的类物质具有对抗内源性和外源性神经营养毒素的作用
Anna E Bartman,Mersad Raeisi,Clarence D Peiris et al.
Anna E Bartman et al.
Numerous insults, both endogenous (e.g., glutamate) and exogenous (e.g., pesticides), compromise the function of the nervous system and pose risk factors for damage or later disease. In previous reports, limonoids such as fraxinellone showe...
Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A [0.03%]
幻觉剂对功能连接的急性影响：裸盖菇素和鼠柳因-A
Frederick A Bagdasarian,Hanne D Hansen,Jingyuan Chen et al.
Frederick A Bagdasarian et al.
The extent of changes in functional connectivity (FC) within functional networks as a common feature across hallucinogenic drug classes is under-explored. This work utilized fMRI to assess the dissociative hallucinogens Psilocybin, a classi...
Chronic Neuropathic Pain and Comorbid Depression Syndrome: From Neural Circuit Mechanisms to Treatment [0.03%]
慢性神经病理性疼痛及其共患抑郁症：从神经环路机制到治疗
Yue Zhang,Hui Ma,Yafan Bai et al.
Yue Zhang et al.
Chronic neuropathic pain and comorbid depression syndrome (CDS) is a major worldwide health problem that affects the quality of life of patients and imposes a tremendous socioeconomic burden. More than half of patients with chronic neuropat...
Discovery of a CK2α'-Biased ATP-Competitive Inhibitor from a High-Throughput Screen of an Allosteric-Inhibitor-Like Compound Library [0.03%]
一类别构抑制剂类化合物库的高通量筛选发现CK2α'偏向型ATP竞争性抑制剂
Deepti Mudaliar,Rachel H Mansky,Angel White et al.
Deepti Mudaliar et al.
Protein kinase CK2 is a holoenzyme composed of two regulatory subunits (CK2β) and two catalytic subunits (CK2α and CK2α'). CK2 controls several cellular processes, including proliferation, inflammation, and cell death. However, CK2α and...
β-Synuclein Intermediates α-Synuclein Neurotoxicity in Parkinson's Disease [0.03%]
β-突触核蛋白介导α-突触核蛋白在帕金森病中的神经毒性作用
Meiyan Xian,Jingwen Li,Tingting Liu et al.
Meiyan Xian et al.
Parkinson's disease (PD) is the second most common age-related neurodegenerative disease in the world, and synuclein is closely related to the onset and progression of PD. Synuclein is considered a therapeutic target for PD. Recent studies ...
Development of CRID3-Based Anti-inflammatory Agents to Ameliorate Chronic Hypoxia-Induced Memory Impairment in Zebrafish Models [0.03%]
基于CRID3的抗炎剂的开发以改善斑马鱼慢性缺氧模型的记忆力损害
Kalyani Soren,Rakesh K Bollikanda,Tapatee Das et al.
Kalyani Soren et al.
Chronic hypoxic exposure triggers the onset and progression of cognitive dysfunction; however, the mechanisms underlying chronic hypoxia-induced neuroinflammation and its contribution to cognitive dysfunction remain poorly understood. Altho...