Polyglutamine (PolyQ) Diseases: Navigating the Landscape of Neurodegeneration [0.03%]
聚谷氨酰胺(PolyQ)疾病：探索神经退行性疾病的景观
Rumiana Tenchov,Janet M Sasso,Qiongqiong Angela Zhou
Rumiana Tenchov
Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with abnormally expanded polyglutamine tract. A total of nine polyQ disorders ha...
Structure-Activity Relationships of the Fentanyl Scaffold: Identification of Antagonists as Potential Opioid Overdose Reversal Agents [0.03%]
芬太尼类阿片受体配体的构效关系及其在阿片类药物过量解救中的应用
Jessica P Anand,Sierra C Moore,Emma E Dixon et al.
Jessica P Anand et al.
Opioid-related overdoses account for almost half of all drug overdose deaths in the United States and cause more preventable deaths every year than car crashes. Fentanyl, a highly potent mu opioid receptor (MOR) agonist and its analogues (f...
Design, Synthesis, and Evaluation of a Novel Conjugate Molecule with Dopaminergic and Neuroprotective Activities for Parkinson's Disease [0.03%]
一种新型多巴胺能及神经保护药物的设计、合成和评价用于帕金森病
Diego Ploper,Agustín O Pernicone,Rodrigo H Tomas-Grau et al.
Diego Ploper et al.
The escalating prevalence of Parkinson's disease (PD) underscores the need for innovative therapeutic interventions since current palliative measures, including the standard l-Dopa formulations, face challenges of tolerance and side effects...
Machine Learned Classification of Ligand Intrinsic Activities at Human μ-Opioid Receptor [0.03%]
基于人类μ型阿片受体的配体固有活性的机器学习分类法
Myongin Oh,Maximilian Shen,Ruibin Liu et al.
Myongin Oh et al.
Opioids are small-molecule agonists of μ-opioid receptor (μOR), while reversal agents such as naloxone are antagonists of μOR. Here, we developed machine learning (ML) models to classify the intrinsic activities of ligands at the human ...
Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na+, K+-ATPase-Activating Antibody after Status Epilepticus [0.03%]
难治性颞叶癫痫兔鼻内给药Na+,K+-ATP酶激活型抗体的脑电图和行为学效应研究
Fernanda Kulinski Mello,Tuane Bazanella Sampaio,Bruna Neuberger et al.
Fernanda Kulinski Mello et al.
Status epilepticus (SE) is a medical emergency associated with high mortality and morbidity. Na+, K+-ATPase, is a promising therapeutic target for SE, given its critical role in regulation of neuron excitability and cellular homeostasis. We...
Correction to "Menthol-Modified Quercetin Liposomes with Brain-Targeting Function for the Treatment of Senescent Alzheimer's Disease" [0.03%]
“薄荷脑修饰石竹菜素脂质体对阿尔茨海默病的治疗作用”的校正通知
Wan-Ying Liu,Yang Yu,Juan Zang et al.
Wan-Ying Liu et al.
Published Erratum
ACS chemical neuroscience. 2024 Jul 10. DOI:10.1021/acschemneuro.4c00398 2024
Alicia González Díaz,Rodrigo Cataldi,Benedetta Mannini et al.
Alicia González Díaz et al.
Aβ oligomers are being investigated as cytotoxic agents in Alzheimer's disease (AD). Because of their transient nature and conformational heterogeneity, the relationship between the structure and activity of these oligomers is still poorly...
Harnessing the Therapeutic Potential of Peptides for Synergistic Treatment of Alzheimer's Disease by Targeting Aβ Aggregation, Metal-Mediated Aβ Aggregation, Cholinesterase, Tau Degradation, and Oxidative Stress [0.03%]
通过靶向Aβ聚集、金属介导的Aβ聚集、胆碱酯酶、Tau蛋白降解和氧化应激协同治疗阿尔茨海默病的肽疗法潜力研究
Kamaljot Singh,Anupamjeet Kaur,Bhupesh Goyal et al.
Kamaljot Singh et al.
Alzheimer's disease (AD) is a progressive multifaceted neurodegenerative disease and remains a formidable global health challenge. The current medication for AD gives symptomatic relief and, thus, urges us to look for alternative disease-mo...
Targeting Microglial Immunoproteasome: A Novel Approach in Neuroinflammatory-Related Disorders [0.03%]
靶向小胶质细胞免疫蛋白酶体：神经炎症相关障碍的新方法
Natalia Malek,Radoslaw Gladysz,Natalia Stelmach et al.
Natalia Malek et al.
It is widely acknowledged that the aging process is linked to the accumulation of damaged and misfolded proteins. This phenomenon is accompanied by a decrease in proteasome (c20S) activity, concomitant with an increase in immunoproteasome (...
MiR-23b-3p Improves Brain Damage after Status Epilepticus by Reducing the Formation of Pathological High-Frequency Oscillations via Inhibition of cx43 in Rat Hippocampus [0.03%]
MicroRNA-23b-3p通过抑制cx43减少病理性高频振荡的形成从而改善全脑缺血后海马损伤
Yanjun Yi,Shimin Zhang,Jiali Dai et al.
Yanjun Yi et al.
In order to investigate the effectiveness and safety of miR-23b-3p in anti-seizure activity and to elucidate the regulatory relationship between miR-23b-3p and Cx43 in the nervous system, we have established a lithium chloride-pilocarpine (...