Synthesis and Biological Evaluation of Colchicine─Aryl/Alkyl Amine Hybrids as Potential Noncytotoxic Cholinesterase Inhibitors: Identification of SBN-284 as a Dual Inhibitor of Cholinesterases and NLRP3 Inflammasome [0.03%]
异丝裂霉素与芳/杂环胺类杂化物作为非细胞毒性的乙酰胆碱酯酶抑制剂的合成和生物活性研究：SBN-284作为乙酰胆碱酯酶和NLRP3炎性小体双重抑制剂的鉴定
Chilakala Nagarjuna Reddy,Vijay K Nuthakki,Ankita Sharma et al.
Chilakala Nagarjuna Reddy et al.
Colchicine, one of the oldest anti-inflammatory natural products still used clinically, inhibits NF-κB signaling and NLRP3 inflammasome activation. Despite its cytotoxicity and narrow therapeutic range, colchicine continues to intrigue med...
Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights [0.03%]
基于分子对接和实验的噻唑并吲唑类胆碱酯酶抑制剂的设计与发展
Fatima Ezzahra Laghchioua,Carlos F M da Silva,Diana C G A Pinto et al.
Fatima Ezzahra Laghchioua et al.
Alzheimer's disease is characterized by a progressive deterioration of cognitive function and memory loss, and it is closely associated with the dysregulation of cholinergic neurotransmission. Since acetylcholinesterase (AChE) is a critical...
Red-Light-Photosensitized Tyrosine 10 Nitration of β-Amyloid1-42 Diverts the Protein from Forming Toxic Aggregates [0.03%]
红光诱导的多巴胺10号位酪氨酸硝化反应使β淀粉样蛋白1-42偏离致病聚集路径
Sarah Basile,Cristina Parisi,Francesco Bellia et al.
Sarah Basile et al.
Several studies have highlighted the presence of nitration damage following neuroinflammation in Alzheimer's disease (AD). Accordingly, post-transcriptional modifications of β-amyloid (Aβ), including peptide nitration, have been explored ...
Healthy Plasma Exosomes Exert Potential Neuroprotective Effects against Methylmalonic Acid-Induced Hippocampal Neuron Injury [0.03%]
健康血浆外泌体对甲基丙二酸致海马神经元损伤的潜在保护作用研究
Wei Zhou,Huizhong Li,Jinxiu Song et al.
Wei Zhou et al.
Exosomes have shown good potential for alleviating neurological deficits and delaying memory deterioration, but the neuroprotective effects of exosomes remain unknown. Methylmalonic acidemia is a metabolic disorder characterized by the accu...
Targeting Oxidative Stress in Neurodegenerative Disorders: A Novel Role for PCSK9 Inhibition? [0.03%]
靶向神经退行性疾病的氧化应激：PCSK9抑制的新作用？
Lauren M Park,Pal Pacher,Falk W Lohoff
Lauren M Park
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein that regulates cholesterol levels by lysosomal low-density lipoprotein receptor (LDLR) degradation and has recently been associated with the production of neuronal oxidative...
Interplay between Copper, Phosphatidylserine, and α-Synuclein Suggests a Link between Copper Homeostasis and Synaptic Vesicle Cycling [0.03%]
铜、磷脂酰丝氨酸和α-突触核蛋白的相互作用提示铜稳态与突触囊泡循环之间的联系
Xiangyu Teng,Ewelina Stefaniak,Keith R Willison et al.
Xiangyu Teng et al.
Copper homeostasis is critical to the functioning of the brain, and its breakdown is linked with many brain diseases. Copper is also known to interact with the negatively charged lipid, phosphatidylserine (PS), as well as α-synuclein, an a...
Rexinoids Induce Differential Gene Expression in Human Glioblastoma Cells and Protein-Protein Interactions in a Yeast Two-Hybrid System [0.03%]
雷尼诺伊德诱导人类胶质母细胞瘤细胞差异表达及蛋白-蛋白相互作用研究
Jennifer F Hackney,Jennifer E Broatch,Rita A Dallal et al.
Jennifer F Hackney et al.
Rexinoids are compounds that bind to the rexinoid X receptor (RXR) to modulate gene expression and have been proposed as a new class of therapeutics to treat Alzheimer's disease. Different rexinoids will initiate downstream effects that can...
Why Is Arginine the Only Amino Acid That Inhibits Polyglutamine Monomers from Taking on Toxic Conformations? [0.03%]
为什么鸟氨酸是唯一一种能够抑制聚谷氨酰胺单体形成有毒构象的氨基酸？
Shoichi Tanimoto,Hisashi Okumura
Shoichi Tanimoto
Polyglutamine (polyQ) diseases are devastating neurodegenerative disorders characterized by abnormal expansion of glutamine repeats within specific proteins. The aggregation of polyQ proteins is a critical pathological hallmark of these dis...
Correction to "Substrate Selection Criteria in Regulated Intramembrane Proteolysis" [0.03%]
关于“调控型跨膜蛋白酶切中的底物选择标准”的更正
Celine Moser,Nadja Guschtschin-Schmidt,Mara Silber et al.
Celine Moser et al.
Published Erratum
ACS chemical neuroscience. 2024 Aug 7;15(15):2956. DOI:10.1021/acschemneuro.4c00406 2024
Exploring the Therapeutic Potential of Benfotiamine in a Sporadic Alzheimer's-Like Disease Rat Model: Insights into Insulin Signaling and Cognitive function [0.03%]
苯芳啶在散发性阿尔茨海默病大鼠模型中治疗潜力的探索：胰岛素信号传导和认知功能的新见解
Camila A E F Cardinali,Yandara A Martins,Ruan C M Moraes et al.
Camila A E F Cardinali et al.
Alzheimer's disease (AD) is a complex neurodegenerative process, also considered a metabolic condition due to alterations in glucose metabolism and insulin signaling pathways in the brain, which share similarities with diabetes. This study ...