Stereoisomers of Chiral Methyl-Substituted Symmetric and Asymmetric Aryl Piperazinium Compounds Exhibit Distinct Selectivity for α9 and α7 Nicotinic Acetylcholine Receptors [0.03%]
光学异构的手性甲基取代对称和非对称芳基派瑞唑ニ윰化合物表现出α9和α7烟碱型乙酰胆碱受体的选择性不同
Hina Andleeb,Roger L Papke,Katrin Richter et al.
Hina Andleeb et al.
We have characterized families of phenylpiperazine (PP) compounds, studying their relative activity with α7 and α9* nicotinic acetylcholine receptors (nAChRs) and focusing on the effects of side groups on the phenyl ring (R1) and the effe...
Phosphodiesterase 2A as a Therapeutic Target for Relieving Mechanical Allodynia and Modulating Microglial Polarization in Neuropathic Pain Models Following Spinal Cord Injury [0.03%]
磷二酯酶2A在脊髓损伤后神经病理性疼痛模型中的镇痛作用及调节小胶质细胞极化的作用及其机制研究
Wen-Jie Yang,Jie Han,Zhen-Xin Cao et al.
Wen-Jie Yang et al.
Spinal cord injury (SCI) is a severe clinical condition often accompanied by multiple complications, with neuropathic pain (NP) being one of the most persistent and difficult conditions to treat. The underlying mechanisms of NP remain uncle...
Biased Signaling Agonists of Dopamine D3 Receptor Differentially Regulate the Effects of Cocaine On Dopamine Transporter Function [0.03%]
多巴胺D3受体偏置激动剂调节可卡因对多巴胺转运蛋白功能作用的差异
Sophie R Cohen,Wei Xu,Nastaran F Aziz et al.
Sophie R Cohen et al.
Cocaine use disorder is a major healthcare issue with no effective FDA-approved treatments. Cocaine exerts its effects - in part - by blocking dopamine transporters (DAT) and subsequently dysregulating DAT function. Several molecular target...
Circadian and Age-Related Variations of Amino Acids Levels in Drosophila Brains: Correlations and Descriptive Dimensions [0.03%]
果蝇脑中氨基酸水平的昼夜和年龄相关变化：相关性及描述维度
Sandrine Parrot,Jacob Crehan,Chloé Aman et al.
Sandrine Parrot et al.
A comprehensive view of whole-brain amino acid levels holds the potential to provide valuable insights into the brain's state, given the mutual interconnections through metabolism, food intake, and neurotransmission. We tested this concept ...
Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic [0.03%]
一种吗啡烷衍生物的合成及其作为双μ-κ阿片受体激动剂镇痛药的药理学研究
Balazs R Varga,Rajendra Uprety,Barnali Paul et al.
Balazs R Varga et al.
We present the synthesis and pharmacological characterization of 3'-iodobenzoylamido epoxymorphinans, with a saturated ring C and devoid of 14-OH, based on a dihydronormorphine backbone with various N-17 alkyl substitutions. All synthesized...
Radiofluorinated Analogs of NCS-382 as Potential PET Tracers for Imaging the CaMKIIα Hub Domain [0.03%]
NCS-382的放射性氟化类似物作为CaMKIIα枢纽结构域成像的潜在PET示踪剂
Ludovica S Sirocchi,Sophie Stotz,Marius Müller et al.
Ludovica S Sirocchi et al.
The Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a key regulator of calcium signaling in the central nervous system and is suggested to play a crucial role in neurodegenerative diseases and stroke. The CaMKIIα hub domain...
Calcium-Dependent S100A8 Amyloid Fibril Formation via S100A1-Mediated Transient Interaction [0.03%]
钙离子依赖的S100A8淀粉样纤维形成通过S100A1介导的瞬态相互作用实现
Viktorija Karalkevičiu̅tė,Ieva Baronaitė,Aistė Peštenytė et al.
Viktorija Karalkevičiu̅tė et al.
The S100 family consists of calcium-binding proteins that are largely known for their contribution to neuroinflammatory processes. These proteins are associated with various cardiac and neurological functions as well as related diseases. A ...
Dual-Function Fluorescent Probes for Neuronal Trans-Differentiation: A Promising Therapeutic Strategy in Neuroregenerative Research [0.03%]
用于神经重编程的双重功能荧光探针：神经再生研究中的有希望的治疗策略
Pratikshya Paudel,Prabir Kumar Gharai
Pratikshya Paudel
Neurodegenerative diseases cause progressive neuronal loss, with current treatments offering only limited symptomatic relief. To overcome this, various strategies are being explored. One promising approach involves converting human mesenchy...
Fluorometric Nanoscale Analysis of Bilirubin and Biliverdin in Human Cerebrospinal Fluid [0.03%]
人脑脊液中胆红素和胆绿素的荧光纳米分析
Paola Sist,Federica Tramer,Arianna Sartori et al.
Paola Sist et al.
Cerebrospinal fluid (CSF) is a valuable source for the quantification of soluble, brain-specific biomarkers supporting the diagnosis of some neurological disorders, infectious diseases, and suspected subarachnoid hemorrhage. Given the incre...
Microgravity-Assisted Exploration of the Conformational Space of Amyloid β Affected by Tottori-Type Familial Mutation D7N [0.03%]
托基尔原发性家族变异D7N影响的淀粉样蛋白β构象空间的微重力辅助探索
Maho Yagi-Utsumi,Saeko Yanaka,Raymond N Burton-Smith et al.
Maho Yagi-Utsumi et al.
The amyloid β (Aβ) Tottori variant (D7N) exhibits unique aggregation behaviors and altered fibril formation, posing challenges for structural characterization. To overcome this, the microgravity environment on the International Space Stat...