Cortical Serotonin Type 2A Receptor Activation Shields Episodic-like Memories from Retroactive Interference in Rodents [0.03%]
大鼠纹状体5-羟色胺2A型受体激活保护间歇性记忆免受逆向干扰的影响
Juan Facundo Morici,Mariana Imperatori,Pablo Koss et al.
Juan Facundo Morici et al.
The acquisition of temporally proximate information can impair the brain's ability to consolidate earlier experiences, resulting in retroactive interference (RI). Recognition-based behavioral paradigms are well-suited for investigating RI i...
Chemokine-Receptor Modulation Shapes Neuroinflammatory and Biomechanical Responses in Organotypic Hippocampal Cultures After Oxygen-Glucose Deprivation [0.03%]
趋化因子受体调节可重塑整体型海马培养模型中氧糖剥夺后的神经炎症和生物力学反应
Natalia Bryniarska-Kubiak,Andrzej Kubiak,Ewa Trojan et al.
Natalia Bryniarska-Kubiak et al.
Ischemic stroke is a life-threatening neurological condition that frequently leads to severe brain damage and long-term disability. Current therapeutic options remain limited and are largely confined to anticoagulant-based interventions. De...
Design and Synthesis of Indole-Based Imidazo[1,2- a]pyridine Derivatives as Antiseizure Candidates: Evaluation in Chemically Induced Seizure Models and In Vitro Antioxidant Assays [0.03%]
基于吲哚的咪唑并[1,2-a]吡啶衍生物的设计、合成及作为抗惊厥候选药物的评价：化学诱导性癫痫模型和体外抗氧化实验评估
Tarfah Al-Warhi,Mahmoud S Elkotamy,Mahmoud Abdelrahman Alkabbani et al.
Tarfah Al-Warhi et al.
This study presents the design and synthesis of a targeted series of indole-based derivatives and their assessment as potential antiseizure candidates. The antiseizure activity of the synthesized compounds was evaluated using two chemically...
Structure-Guided Discovery of a Bis-Pyridyl Diamine-Based Dual CDK7/9 Inhibitor with In Vitro and In Vivo Antitumor Efficacy in Glioblastoma Multiforme [0.03%]
结构指导的双吡啶二胺类CDK7/9抑制剂的发现及其对多形性胶质母细胞瘤的体内外抗肿瘤功效研究
Nithya Sree Pr,Tejaswi Somarowthu,Jeyasankari S et al.
Nithya Sree Pr et al.
Glioblastoma multiforme (GBM) is a lethal and fast-growing brain cancer that is difficult to treat with standard medical interventions. GBM tumors often overexpress cyclin-dependent kinase 9, in complex with cyclin T1, and thus, it represen...
Gut Microbiota Dysbiosis Drives Early Alzheimer's Pathogenesis via Microglial TREM2/SYK/NF-κB Signaling Axis [0.03%]
肠菌失调通过小胶质细胞TREM2/SYK/NF-κB信号轴驱动阿尔茨海默病的早期发病进程
Minjie Tian,Duohao Wang,Chi Zhang et al.
Minjie Tian et al.
Gut microbiota dysbiosis is implicated in Alzheimer's disease (AD), but causal evidence and mechanisms linking it to microglial dysfunction remain unclear. This study aimed to determine whether gut microbiota drives neuroinflammation and co...
Advances in Real-Time Electrochemical Monitoring of Neurotransmitter Dynamics in Drosophila [0.03%]
飞蛾实时电化学监测神经传递动力学的研究进展
Linfeng Meng,Wendong Liu,Yadong Niu et al.
Linfeng Meng et al.
Drosophila melanogaster is a genetically tractable model organism with a compact yet functionally rich nervous system, making it ideal for investigating neural mechanisms and modeling neurological diseases. However, its small brain size pos...
A Proline-Rich-Domain-Binding Single Domain Antibody Selectively Inhibits RNA-Induced Phase Separation of Tau [0.03%]
一个富含脯氨酸的结构域结合型单域抗体选择性地抑制tau蛋白的RNA诱导相分离作用
Simon Thiou,Leslie Martin,Evangelia Manousaki et al.
Simon Thiou et al.
Phase separation mediates the formation of biomolecular condensates, which organize cellular processes such as synaptic plasticity in neurons. The neuronal protein tau undergoes phase separation under specific conditions, regulating synapti...
Biomaterials and Nanoparticle-Based Therapeutics in Neurodegenerative Diseases: Bridging the Gap Between Innovation and Translation [0.03%]
基于生物材料和纳米粒子的神经退行性疾病治疗药物：创新与转化之间的桥梁
Dia Panchal,Dattavi Solanki,Raghu Solanki et al.
Dia Panchal et al.
Neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and multiple sclerosis, represent a growing global health crisis characterized by irreversible neuronal loss, protein aggregation, ...
Synthesis of Clausenamide Isomers and Evaluation of Their Potential as Cortical Neuroplastogens [0.03%]
克劳森胺异构体的合成及其作为皮质神经塑形剂潜力的评估
Yongyu Ou,Yara A Khatib,Adam Mosswood et al.
Yongyu Ou et al.
Neuroplastogens, small molecules that induce beneficial neuronal growth and plasticity, are a class of compounds emerging as new drugs for treating a range of central nervous system conditions. Clausenamide is a plasticity-promoting natural...
Profiling Endogenous Opioid Peptide Release from Adrenal Chromaffin Cells [0.03%]
肾上腺嗜铬细胞内源性阿片肽释放的特征研究
Jenna M Berger,J Dylan Denison,A Chathuri De Alwis et al.
Jenna M Berger et al.
Despite longstanding recognition that the adrenal medulla is a major source of both catecholamines and opioid peptides, direct measurements of opioid peptide release kinetics─and characterization of the full complexity of the peptidergic f...