Psilocybin Facilitates Fear Extinction: Importance of Dose, Context, and Serotonin Receptors [0.03%]
裸头菌素促进恐惧消退：剂量、情境和血清素受体的重要性
Samuel C Woodburn,Caleb M Levitt,Allison M Koester et al.
Samuel C Woodburn et al.
A variety of classic psychedelics and MDMA have been shown to enhance fear extinction in rodent models. This has translational significance because a standard treatment for post-traumatic stress disorder (PTSD) is prolonged exposure therapy...
Inflammasome-Inhibiting Nanoligomers Are Neuroprotective against Space-Induced Pathology in Healthy and Diseased Three-Dimensional Human Motor and Prefrontal Cortex Brain Organoids [0.03%]
针对健康和疾病状态下的三维人类运动和前额叶脑类器官的太空诱导病理，抑炎纳米配体具有神经保护作用
Sadhana Sharma,Vincenzo S Gilberto,Jon Rask et al.
Sadhana Sharma et al.
The microgravity and space environment has been linked to deficits in neuromuscular and cognitive capabilities, hypothesized to occur due to accelerated aging and neurodegeneration in space. While the specific mechanisms are still being inv...
Pharmacological Activities and Molecular Mechanisms of Sinapic Acid in Neurological Disorders [0.03%]
芥酸在神经系统疾病中的药理活性和分子机制
Mahan Farzan,Behnaz Abedi,Iman Bhia et al.
Mahan Farzan et al.
Sinapic acid (SA) is a phenylpropanoid derivative found in various natural sources that exhibits remarkable versatile properties, including antioxidant, anti-inflammatory, and metal-chelating capabilities, establishing itself as a promising...
O-GlcNAc Modification of α-Synuclein Can Alter Monomer Dynamics to Control Aggregation Kinetics [0.03%]
O-GlcNAc修饰的α-突触核蛋白可以通过改变单体动力学来控制聚集速率
Kasun Gamage,Binyou Wang,Eldon R Hard et al.
Kasun Gamage et al.
The intrinsically disordered protein α-Synuclein is identified as a major toxic aggregate in Parkinson's as well as several other neurodegenerative diseases. Recent work on this protein has focused on the effects of posttranslational modif...
Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer's Disease [0.03%]
设计、合成及生物活性评价新的茋类化合物作为老年性痴呆治疗药物的先导物研究
Gourav Singh,Sunil Kumar,Samir Ranjan Panda et al.
Gourav Singh et al.
Alzheimer's disease (AD) is the most prevalent cause of dementia and is characterized by low levels of acetyl and butyrylcholine, increased oxidative stress, inflammation, accumulation of metals, and aggregations of Aβ and tau proteins. Cu...
Allosteric Activation of SIRT1 by 2,4-Dihydroxy-azaflavanone Averts MPP+-Mediated Dysfunction in Mitochondrial Biogenesis and Bioenergetics: Implications for Parkinson's Disease [0.03%]
2,4-二羟基氮杂花青酮通过别构激活SIRT1来避免MPP+介导的线粒体生物发生和生物能量功能障碍：帕金森病的意义
Chitrakshi Pant,Genji Sukumar,Vidya Jyothi Alli et al.
Chitrakshi Pant et al.
Parkinson's disease (PD) is a complex neurodegenerative disorder that affects dopamine neurons of the substantia nigra pars compacta (SNpc), resulting in motor dysfunction. Among the pathways examined, mitochondria and α-synuclein were fou...
TDP-43 Promotes Amyloid-Beta Toxicity by Delaying Fibril Maturation via Direct Molecular Interaction [0.03%]
TDP-43通过直接分子相互作用延缓纤维成熟从而促进淀粉样蛋白毒性
Adam J Gatch,Feng Ding
Adam J Gatch
Amyloid-β (Aβ) is a peptide that undergoes self-assembly into amyloid fibrils, which compose the hallmark plaques observed in Alzheimer's disease (AD). TAR DNA-binding protein 43 (TDP-43) is a protein with mislocalization and aggregation ...
Applying Spatial Metabolomics To Investigate Age- and Drug-Induced Neurochemical Changes [0.03%]
基于空间代谢组学技术研究年龄及药物诱导的神经化学变化地图谱
Theodosia Vallianatou,Tina B Angerer,Ibrahim Kaya et al.
Theodosia Vallianatou et al.
In an era when population aging is increasing the burden of neurodegenerative conditions, deciphering the mechanisms underlying brain senescence is more important than ever. Here, we present a spatial metabolomics analysis of age-induced ne...
Native Mass Spectrometry-Centric Approaches Revealed That Neuropeptides Frequently Interact with Amyloid-β [0.03%]
基于原位质谱的脑内神经肽与淀粉样蛋白-β相互作用研究
Danyang Wang,Guibin Wang,Xiankun Wang et al.
Danyang Wang et al.
Amyloid-β (Aβ) aggregates are recognized as initiators of Alzheimer's disease, and their interaction with the nervous system contributes to the progression of neurodegeneration. Herein, we investigated the frequency at which neuropeptides...
Hypoxic-Ischemic Insult Alters Polyamine and Neurotransmitter Abundance in the Specific Neonatal Rat Brain Subregions [0.03%]
缺氧缺血损伤改变新生鼠脑特定区室多胺及神经递质含量
Hynek Mácha,Dominika Luptáková,Ivo Juránek et al.
Hynek Mácha et al.
Neonatal hypoxic-ischemic (HI) brain insult is a major cause of neonatal mortality and morbidity. To assess the underlying pathological mechanisms, we mapped the spatiotemporal changes in polyamine, amino acid, and neurotransmitter levels, ...