Fluorescence-Based Monitoring of Early-Stage Aggregation of Amyloid-β, Amylin Peptide, Tau, and α-Synuclein Proteins [0.03%]
基于荧光的淀粉样蛋白-β、胰岛素衍生肽、tau和α-突触核蛋白蛋白质早期聚集监测技术
Yuanjie Li,Saurabh Awasthi,Louise Bryan et al.
Yuanjie Li et al.
Early-stage aggregates of amyloid-forming proteins, specifically soluble oligomers, are implicated in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Protein aggregation is typically mo...
Hybrid Amyloid Quantum Dot Nano-Bio Assemblies to Probe Neuroinflammatory Damage [0.03%]
用于探测神经炎症损伤的混合型淀粉样量子点纳米-生物组件
Wesley Chiang,Jennifer M Urban,Francine Yanchik-Slade et al.
Wesley Chiang et al.
Various oligomeric species of amyloid-beta have been proposed to play different immunogenic roles in the cellular pathology of Alzheimer's Disease. The dynamic interconversion between various amyloid oligomers and fibrillar assemblies makes...
The Usnic Acid Analogue 4-FPBUA Enhances the Blood-Brain Barrier Function and Induces Autophagy in Alzheimer's Disease Mouse Models [0.03%]
异乌头酸类似物4-FPBUA可改善阿尔茨海默病模型小鼠的血脑屏障功能并诱导自噬
Sweilem B Al Rihani,Khaled H Elfakhri,Hassan Y Ebrahim et al.
Sweilem B Al Rihani et al.
Preclinical and clinical studies have indicated that compromised blood-brain barrier (BBB) function contributes to Alzheimer's disease (AD) pathology. BBB breakdown ranged from mild disruption of tight junctions (TJs) with increased BBB per...
Anaerobic Glycolysis and Ischemic Stroke: From Mechanisms and Signaling Pathways to Natural Product Therapy [0.03%]
缺氧糖酵解与脑卒中：从机制和信号通路到天然药物治疗
Jia Pu,Jin Han,Jiehong Yang et al.
Jia Pu et al.
Ischemic stroke is a serious condition that results in high rates of illness and death. Anaerobic glycolysis becomes the primary means of providing energy to the brain during periods of low oxygen levels, such as in the aftermath of an isch...
Comprehending the Efficacy of Whitlock's Caffeine-Pincered Molecular Tweezer on β-Amyloid Aggregation [0.03%]
惠特洛克咖啡因夹环分子夹对β-淀粉样蛋白聚集的作用机制研究
Madhusmita Devi,Sandip Paul
Madhusmita Devi
Alzheimer's disease (AD) stands as one of the most prevalent neurodegenerative conditions, leading to cognitive impairment, with no cure and preventive measures. Misfolding and aberrant aggregation of amyloid-β (Aβ) peptides are believed ...
iTRAQ-Based Serum Proteomic Analysis Reveals Multifactorial Cellular Function Impairment and Aggravated Systematic Inflammation in Drug-free Obsessive-Compulsive Disorders [0.03%]
基于iTRAQ的血清蛋白组学分析揭示了药物-free强迫症的多因素细胞功能障碍和系统性炎症加重
Miaohan Deng,Xia Li,Dongdong Shi et al.
Miaohan Deng et al.
Obsessive-compulsive disorder (OCD) is a debilitating mental disorder with obvious difficulties in treatment. Its pathogenesis has not been fully elucidated. Further understanding of etiology and mechanism needs to be explored further. We e...
Pterostilbene Ameliorates Cognitive Impairment in Polycystic Ovary Syndrome Rat Model through Improving Insulin Resistance via the IRS-1/PI3K/Akt/GSK-3β Pathway: A Comparative Study with Metformin [0.03%]
白藜芦醇通过改善胰岛素抵抗来缓解多囊卵巢综合征大鼠模型的认知障碍：与二甲双胍比较研究（IRS-1/PI3K/Akt/GSK-3β途径）
Aliaa M Foda,Safinaz S Ibrahim,Sherehan M Ibrahim et al.
Aliaa M Foda et al.
Polycystic ovary syndrome (PCOS) is an intricate endocrine disorder that targets millions of women globally. Recent research has drawn attention to its association with cognitive impairment and Alzheimer's disease (AD) risk, yet the exact m...
Comparative Study
ACS chemical neuroscience. 2024 Aug 21;15(16):3064-3077. DOI:10.1021/acschemneuro.4c00352 2024
Neuromicrobiology Comes of Age: The Multifaceted Interactions between the Microbiome and the Nervous System [0.03%]
神经微生物学走向成熟：肠道菌群与神经系统之间的多方面联系
Ashwarya S Devason,Christoph A Thaiss,Cesar de la Fuente-Nunez
Ashwarya S Devason
The past decade has seen an explosion in our knowledge about the interactions between gut microbiota, the central nervous system, and the immune system. The gut-brain axis has recently gained much attention due to its role in regulating hos...
Repurposing Anidulafungin for Alzheimer's Disease via Fragment-Based Drug Discovery [0.03%]
基于片段的药物设计中Anidulafungin治疗阿尔茨海默病的新用途研究
Siqi Xie,Yumei Liang,Yang Song et al.
Siqi Xie et al.
The misfolding and aggregation of beta-amyloid (Aβ) peptides have been implicated as key pathogenic events in the early stages of Alzheimer's disease (AD). Inhibiting Aβ aggregation represents a potential disease-modifying therapeutic app...
Predicting the Hallucinogenic Potential of Molecules Using Artificial Intelligence [0.03%]
利用人工智能预测分子的致幻潜力
Fabio Urbina,Thane Jones,Joshua S Harris et al.
Fabio Urbina et al.
The development of new drugs addressing serious mental health and other disorders should avoid the psychedelic experience. Analogs of psychedelic drugs can have clinical utility and are termed "psychoplastogens". These represent promising c...