Low-Dose Radiation Induces Alterations in Fatty Acid and Tyrosine Metabolism in the Mouse Hippocampus: Insights from Integrated Multiomics [0.03%]
低剂量辐射诱导小鼠海马脂肪酸和酪氨酸代谢改变：集成多组学见解
Rekha Koravadi Narasimhamurthy,Babu Santhi Venkidesh,Sampara Vasishta et al.
Rekha Koravadi Narasimhamurthy et al.
In recent years, there has been a drastic surge in neurological disorders with sporadic cases contributing more than ever to their cause. Radiation exposure through diagnostic or therapeutic routes often results in neurological injuries tha...
Metabolomics Unveils Disrupted Pathways in Parkinson's Disease: Toward Biomarker-Based Diagnosis [0.03%]
代谢组学揭示帕金森病的紊乱途径：迈向基于生物标志物的诊断方法
Wanderleya T Santos,Albert Katchborian-Neto,Gabriel S Viana et al.
Wanderleya T Santos et al.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by diverse symptoms, where accurate diagnosis remains challenging. Traditional clinical observation methods often result in misdiagnosis, highlighting the need for bioma...
Mechanistic Approach to Immunity and Immunotherapy of Alzheimer's Disease: A Review [0.03%]
阿尔茨海默病免疫和免疫治疗的机制研究：综述文章
Md Rubiath Islam,Md Afser Rabbi,Tanbir Hossain et al.
Md Rubiath Islam et al.
Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive decline and memory loss, affecting millions of people worldwide. Traditional treatments, such as cholinesterase inhibitors and NMD...
Pore Formation by Amyloid-like Peptides: Effects of the Nonpolar-Polar Sequence Pattern [0.03%]
类似淀粉样蛋白的肽的孔形成：非极性-极性序列模式的影响
Warin Rangubpit,Siwaporn Sungted,Jirasak Wong-Ekkabut et al.
Warin Rangubpit et al.
One of the mechanisms accounting for the toxicity of amyloid peptides in diseases like Alzheimer's and Parkinson's is the formation of pores on the plasma membrane of neurons. Here, we perform unbiased all-atom simulations of the full membr...
Discovery and Profiling of New Multimodal Phenylglycinamide Derivatives as Potent Antiseizure and Antinociceptive Drug Candidates [0.03%]
一类新型苯甘氨酰胺衍生物的发现及多模态镇痛和抗癫痫活性研究
Marcin Jakubiec,Michał Abram,Mirosław Zagaja et al.
Marcin Jakubiec et al.
We developed a focused series of original phenyl-glycinamide derivatives which showed potent activity across in vivo mouse seizure models, namely, maximal electroshock (MES) and 6 Hz (using both 32 and 44 mA current intensities) seizure mod...
Fan Qi,Hao He,Yujie Zhu
Fan Qi
Dendritic spines function as postsynaptic sites, receiving excitatory signals from presynaptic axons. The synaptic plasticity of spines underlies the refinement of neuronal circuits. Neural cognitive disorders are commonly associated with t...
Multicolorimetric Sensor Array Based on Silver Metallization of Gold Nanorods for Discriminating Dopaminergic Agents [0.03%]
基于银原子层沉积修饰金纳米棒的多色光传感器件检测多巴胺药物
Reza Koohsar,Afsaneh Orouji,Mohammad Reza Hormozi-Nezhad
Reza Koohsar
Dopaminergic agents are compounds that modulate dopamine-related activity in the brain and peripheral nerves within the pathways on both sides of the blood-brain barrier. Atypical levels of them can precipitate a multitude of neurological d...
Exploring Novel GSK-3β Inhibitors for Anti-Neuroinflammatory and Neuroprotective Effects: Synthesis, Crystallography, Computational Analysis, and Biological Evaluation [0.03%]
用于抗神经炎症和神经营养作用的新型GSK-3β抑制剂的探索：合成，晶体学，计算分析和生物评价
Izabella Góral,Tomasz Wichur,Emilia Sługocka et al.
Izabella Góral et al.
In the pathogenesis of Alzheimer's disease, the overexpression of glycogen synthase kinase-3β (GSK-3β) stands out due to its multifaced nature, as it contributes to the promotion of amyloid β and tau protein accumulation, as well as neur...
Structural Reorganization Mechanism of the Aβ42 Fibril Mediated by N-Substituted Oligopyrrolamide ADH-353 [0.03%]
N-取代寡吡咯酰胺ADH-353介导的Aβ42纤维丝结构重构机制
Arushi Dabas,Bhupesh Goyal
Arushi Dabas
The inhibition of amyloid-β (Aβ) fibrillation and clearance of Aβ aggregates have emerged as a potential pharmacological strategy to alleviate Aβ aggregate-induced neurotoxicity in Alzheimer's disease (AD). Maity et al. shortlisted ADH-...
Defining the Spatial Resolution of Analyte Recovery during Microperfusion-Based Sampling of Brain Parenchyma [0.03%]
基于脑实质取样的微透析采集中靶分析物回收的空间分辨率的界定
Luke A Stangler,Su-Youne Chang,Inyong Kim et al.
Luke A Stangler et al.
The unique architecture of the brain and the blood-brain barrier imposes challenges for the measurement of parenchyma-derived biomarkers that prevent sufficient understanding of transient neuropathogenic processes. One solution to this chal...