Comparison of Neurogenesis Promotion Effects between Cinnamoylquinic Acids in Neural Stem Cells from Adult Mice Brains [0.03%]
来源于脑成人鼠神经干细胞中桂皮酰奎尼酸衍生物促神经发生作用的比较研究
Hongyu Lin,Kazunori Sasaki,Farhana Ferdousi et al.
Hongyu Lin et al.
Caffeoylquinic acids (CQAs) and feruloylquinic acids (FQAs), as cinnamoylquinic acids, have neurogenesis promotion effects. We studied for the first time the neurogenesis-enhancing effect of 3,4,5-tri-feruloylquinic acid (TFQA) compared to ...
Dishank Patel,Ritu Soni,Jigna Shah
Dishank Patel
Parkinson's disease (PD) is the second most prevailing degenerative disease that deals with dopaminergic neuronal loss and deficiency of dopamine in SNpc and striatum. Manifestations primarily include motor symptoms like tremor, rigidity, a...
Fecal Microbiota Transplantation-Mediated Rebalancing of the Gut-Brain Axis Alleviates Cisplatin-Induced Neuropathic Pain [0.03%]
粪便微生物移植介导的肠-脑轴再平衡可缓解顺铂诱导的神经病理性疼痛
Mousmi Rani,Akhilesh,Deepak Chouhan et al.
Mousmi Rani et al.
Chemotherapy-induced neuropathic pain (CINP) presents a significant challenge in cancer treatment, necessitating novel therapeutic approaches. The intricate relationship between CINP and the gut-brain axis indicates a crucial role for the g...
Blocking α1 Adrenergic Receptor as a Novel Target for Treating Alzheimer's Disease [0.03%]
阻断α1肾上腺素受体作为治疗阿尔茨海默病的新靶点
Xidong Pan,Zhifeng Lei,Jiang Chen et al.
Xidong Pan et al.
While amyloidopathy and tauopathy have been recognized as hallmarks in Alzheimer's disease (AD) brain, recently, increasing lines of evidence have supported the pathological roles of cerebrovascular changes in the pathogenesis and progressi...
Glycation Produces Topologically Different α-Synuclein Oligomeric Strains and Modulates Microglia Response via the NLRP3-Inflammasome Pathway [0.03%]
糖化产生拓扑结构不同的α-突触核蛋白寡聚毒株并通过NLRP3炎性小体途径调节小胶质细胞反应
Manisha Kumari,Krishna Singh Bisht,Kriti Ahuja et al.
Manisha Kumari et al.
α-Synuclein, a key player in Parkinson's disease and other synucleinopathies, possesses an inherently disordered structure that allows for versatile structural changes during aggregation. Microglia, the brain immune cells, respond differen...
Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) [0.03%]
VU6016235的发现：一种高选择性、口服生物利用度良好且结构独特的M4胆碱能受体激动剂类正向变构调节剂
Julie L Engers,Logan A Baker,Sichen Chang et al.
Julie L Engers et al.
Herein, we report structure-activity relationship (SAR) studies to develop novel tricyclic M4 PAM scaffolds with improved pharmacological properties. This endeavor involved a "tie-back" strategy to replace a 5-amino-2,4-dimethylthieno[2,3-d...
H T Evans,T Ko,M M Oliveira et al.
H T Evans et al.
Elucidating the mechanisms by which protein synthesis contributes to complex biological processes has remained a challenging endeavor. This is particularly true in the field of neuroscience, where multiple, tightly regulated periods of new ...
Alzheimer's Disease Immunotherapy and Mimetic Peptide Design for Drug Development: Mutation Screening, Molecular Dynamics, and a Quantum Biochemistry Approach Focusing on Aducanumab::Aβ2-7 Binding Affinity [0.03%]
针对阿杜那单抗::Aβ2-7结合亲和力的阿尔茨海默病免疫疗法及模拟肽设计药物开发的突变筛查、分子动力学及量子生化方法研究
Victor L B França,Eveline M Bezerra,Roner F da Costa et al.
Victor L B França et al.
Seven treatments are approved for Alzheimer's disease, but five of them only relieve symptoms and do not alter the course of the disease. Aducanumab (Adu) and lecanemab are novel disease-modifying antiamyloid-β (Aβ) human monoclonal antib...
Untargeted Metabolomics and Quantitative Analysis of Tryptophan Metabolites in Myalgic Encephalomyelitis Patients and Healthy Volunteers: A Comparative Study Using High-Resolution Mass Spectrometry [0.03%]
非目标代谢组学和高分辨率质谱定量分析乙型脑炎患者及健康志愿者中色氨酸代谢物的比较研究
Sandy Abujrais,Theodosia Vallianatou,Jonas Bergquist
Sandy Abujrais
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, complex illness characterized by severe and often disabling physical and mental fatigue. So far, scientists have not been able to fully pinpoint the biological cause ...
Comparative Study
ACS chemical neuroscience. 2024 Oct 2;15(19):3525-3534. DOI:10.1021/acschemneuro.4c00444 2024
Functional Characterization of an Arylsulfonamide-Based Small-Molecule Inhibitor of the NLRP3 Inflammasome [0.03%]
基于芳基磺胺的NLRP3炎症小体的小分子抑制剂的功能表征
Savannah Biby,Prasenjit Mondal,Yiming Xu et al.
Savannah Biby et al.
Considerable evidence indicates that the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome plays key roles in human pathophysiology, suggesting it as a potential drug target. Currently, studies have yet to develop comp...