Transcriptome-Wide Profiling of Nascent RNA in Neurons with Enriched H3K27ac Signal Elevates eRNA Identification Efficiency [0.03%]
富H3K27ac信号神经元中转录组范围内的新生RNA谱分析可提高lncRNA的识别效率
Jiazhi Jiang,Sha Liu,Ziyue Xu et al.
Jiazhi Jiang et al.
Growing evidence suggests that activity-dependent gene expression is crucial for neuronal plasticity and behavioral experience. Enhancer RNAs (eRNAs), a class of long noncoding RNAs, play a key role in these processes. However, eRNAs are hi...
Molecular Interactions between Tau Protein and TIA1: Distinguishing Physiological Condensates from Pathological Fibrils [0.03%]
Tau蛋白与TIA1分子间相互作用：生理凝聚体与病理原纤维的区别
Safwa T Kizhakkeduth,Arshad Abdul Vahid,Muhammed Shafeek Oliyantakath Hassan et al.
Safwa T Kizhakkeduth et al.
The interaction of tau protein with other key proteins essential for stress granule formation determines their functional and pathological impact. In a biological framework, the synergy between Alzheimer's associated tau protein and the str...
Ferroptosis Regulated by 5-HT3a Receptor via Calcium/Calmodulin Signaling Contributes to Neuropathic Pain in Brachial Plexus Avulsion Rat Models [0.03%]
5-HT3a受体通过钙/calmodulin信号转导调节的铁死亡在臂丛神经撕脱大鼠模型中参与神经病理性疼痛
Chengpeng Liao,Jinding Guo,Shenqian Li et al.
Chengpeng Liao et al.
Neuropathic pain is a prevalent complication following brachial plexus avulsion (BPA). Ferroptosis has been implicated in various nervous system disorders. However, the association between ferroptosis and neuropathic pain induced by BPA rem...
Discovering Effective Chiral Dipeptides against Aβ(1-42) Aggregation by the Computational Screening Strategy [0.03%]
基于计算筛选策略发现有效的手性二肽抑制Aβ(1-42)聚集作用
Wenhui Shi,Jiaxing Zhang,Zixuan Wang et al.
Wenhui Shi et al.
The β-sheet-breaker (BSB) peptides inhibiting amyloidogenic aggregation have been extensively studied. However, the inhibition efficacy of ultrashort chiral dipeptides remains inadequately understood. In this study, we proposed a computati...
TDP-43 Amyloid Fibril Formation via Phase Separation-Related and -Unrelated Pathways [0.03%]
与相分离相关和非相分离的TDP-43淀粉样纤维形成途径
Pin-Han Lin,Guan-Wei Wu,Yu-Hao Lin et al.
Pin-Han Lin et al.
Intrinsically disordered regions (IDRs) in proteins can undergo liquid-liquid phase separation (LLPS) for functional assembly, but this increases the chance of forming disease-associated amyloid fibrils. Not all amyloid fibrils form through...
Thitima Pewklang,Tye Thompson,Arthur Sefiani et al.
Thitima Pewklang et al.
Neurotrophins (NTs) elicit the growth, survival, and differentiation of neurons and other neuroectoderm tissues via activation of Trk receptors. Hot spots for NT·Trk interactions involve three neurotrophin loops. Mimicry of these using "cy...
Correction to "Structure-Activity Relationships of the Fentanyl Scaffold: Identification of Antagonists as Potential Opioid Overdose Reversal Agents" [0.03%]
有关苯噻眯类镇痛药支架的构效关系的纠错：“苯噻咪类支架结构活性关系：识别拮抗剂作为潜在的阿片类药物过量逆转剂”
Jessica P Anand,Sierra C Moore,Emma E Dixon et al.
Jessica P Anand et al.
Published Erratum
ACS chemical neuroscience. 2024 Oct 2;15(19):3587-3588. DOI:10.1021/acschemneuro.4c00579 2024
Can Targeted Protein Degradation Technology Provide a Potential Breakthrough in the Development of Anti-AD Drugs? [0.03%]
靶向蛋白降解技术会为抗阿尔兹海默症药物研发带来突破吗？
Baichen Xiong,Zuoaoyun Song,Leyan Wang et al.
Baichen Xiong et al.
Recent advancements in Alzheimer's disease (AD) research have led to the approval of lecanemab and donanemab, highlighting the effectiveness of amyloid-beta (Aβ) degradation as a treatment for AD. The prospect of small molecule Aβ degrade...
Impact of Indole Inclusion in the Design of Multi-Tactical Metal-Binding Tetra-Aza Macrocycles that Target the Molecular Features of Neurodegeneration [0.03%]
含吲哚四氮杂大环配体的设计及其金属配合物对神经退行性疾病治疗的潜在作用研究
Kristof Pota,Shrikant Nilewar,Christina Mantsorov et al.
Kristof Pota et al.
Numerous small molecules have been studied for their ability to counteract oxidative stress, a key contributor to neurodegenerative diseases such as Alzheimer's. Despite these efforts, the pharmacological properties and structure-activity r...
The Interplay between MiR-134/BDNF and LKB1/AMPK/SIRT1 Accentuates the Antidepressant Efficacy of Empagliflozin in Ovariectomized Rats [0.03%]
MiR-134/BDNF和LKB1/AMPK/SIRT1的相互作用增强了恩格列净在卵巢切除大鼠中的抗抑郁功效
Nevine Fathy,Merna A Labib,Reham M Essam et al.
Nevine Fathy et al.
Major depressive disorder (MDD) is considered a major cause of suicide worldwide. As previous studies revealed that neuroinflammation is a significant factor in the etiology of MDD, this study proposed to unravel the possible antidepressant...