Disruption of PHF6 Peptide Aggregation from Tau Protein: Mechanisms of Palmatine Chloride in Preventing Early PHF6 Aggregation [0.03%]
小檗红碱氯化物通过抑制PHF6肽聚集预防tau蛋白病的机制研究
Charline Fagnen,Johanna Giovannini,Thomas Vignol et al.
Charline Fagnen et al.
The formation of neurofibrillary tangles (NFTs), composed of tau protein aggregates, is a hallmark of neurodegenerative diseases known as tauopathies, including Alzheimer's disease (AD). NFTs consist of paired helical filaments (PHFs) of ta...
Maxence Noel,Suttipong Suttapitugsakul,Mohui Wei et al.
Maxence Noel et al.
The synapse is an essential connection between neuronal cells in which the membrane and secreted glycoproteins regulate neurotransmission. The post-translational modifications of glycoproteins with carbohydrates, although essential for thei...
Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation [0.03%]
来自ALS患者的细胞衍生蛋白聚集物用于个性化药物评估
Carmen Pérez de la Lastra Aranda,Carlota Tosat-Bitrián,Gracia Porras et al.
Carmen Pérez de la Lastra Aranda et al.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that currently lacks effective therapy. Given the heterogeneity of clinical and molecular profiles of ALS patients, personalized diagnostics and pathological ch...
Propionate Decreases Microglial Activation but Impairs Phagocytic Capacity in Response to Aggregated Fibrillar Amyloid Beta Protein [0.03%]
丙酸盐减少微胶质细胞活化但损害对聚集淀粉样蛋白β原纤维的吞噬能力
Andrew Gold,Sarah Kaye,Jie Gao et al.
Andrew Gold et al.
Microglia, the innate immune cell of the brain, are a principal player in Alzheimer's disease (AD) pathogenesis. Their surveillance of the brain leads to interaction with the protein aggregates that drive AD pathogenesis, most notably Amylo...
Interactions of Polychlorinated Biphenyls and Their Metabolites with the Brain and Liver Transcriptome of Female Mice [0.03%]
多氯联苯及其代谢产物与小鼠脑和肝转录组的相互作用
Amanda J Bullert,Hui Wang,Anthony E Valenzuela et al.
Amanda J Bullert et al.
Exposure to polychlorinated biphenyls (PCBs) is linked to neurotoxic effects. This study aims to close knowledge gaps regarding the specific modes of action of PCBs in female C57BL/6J mice (>6 weeks) orally exposed for 7 weeks to a human-re...
Rumiana Tenchov,Janet M Sasso,Qiongqiong Angela Zhou
Rumiana Tenchov
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid beta plaques and tau protein ...
Comment on "Extracellular Vesicles Slow Down Aβ(1-42) Aggregation by Interfering with the Amyloid Fibril Elongation Step" [0.03%]
关于“细胞外囊泡通过干扰淀粉样纤维伸长阶段来减慢Aβ(1-42)聚合”的点评
Mohsin Shafiq,Andreu Matamoros-Angles,Sussane Caroline Meister et al.
Mohsin Shafiq et al.
Halipi et al. explored the impact of extracellular vesicles (EVs) on amyloid-β (Aβ) aggregation. They concluded that EVs reduce Aβ aggregation, as seen by shorter and thicker fibrils. While we agree with the complex role of EVs in Alzhei...
Yu Nishio,Craig W Lindsley,Aaron M Bender
Yu Nishio
Tianeptine (1) is an unusual antidepressant in that its mechanism of action appears to be independent from any activity at serotonin receptors or monoamine transporters. In fact, tianeptine has been shown to be a moderately potent agonist f...
Mannose-Functionalized Chitosan-Coated PLGA Nanoparticles for Brain-Targeted Codelivery of CBD and BDNF for the Treatment of Alzheimer's Disease [0.03%]
甘露糖功能化壳聚糖涂层PLGA纳米颗粒脑靶向递送CBD和BDNF联合治疗阿尔茨海默病
Arun Kumar Mahanta,Bivek Chaulagain,Riddhi Trivedi et al.
Arun Kumar Mahanta et al.
Alzheimer's disease (AD) is a common neurodegenerative disease causing cognitive and memory decline. AD is characterized by the deposition of amyloid-β and hypophosphorylated forms of tau protein. AD brains are found to be associated with ...
Ketul V Patel,Vinicius M Gadotti,Agustin Garcia-Caballero et al.
Ketul V Patel et al.
Chronic pain affects a substantial portion of the population, posing a significant health challenge. Current treatments often come with limitations and side effects, necessitating novel therapeutic approaches. Our study focuses on disruptin...