Shuoyan Tan,Huanxiang Liu,Xiaojun Yao
Shuoyan Tan
Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders, with current treatments offering only temporary symptomatic relief. There is an urgent need for the development of novel therapeutic approaches. Abnormal inc...
Structural Insights into Dopamine Receptor-Ligand Interactions: From Agonists to Antagonists [0.03%]
多巴胺受体配体相互作用的结构见解：从激动剂到拮抗剂
Emmanuel D Barbosa,Yuanyuan Ma,Heather E Clift et al.
Emmanuel D Barbosa et al.
This study explores the intricacies of dopamine receptor-ligand interactions, focusing on the D1R and D5R subtypes. Using molecular modeling techniques, we investigated the binding of the pan-agonist rotigotine, revealing a universal bindin...
AI-Enabled Ultra-large Virtual Screening Identifies Potential Inhibitors of Choline Acetyltransferase for Theranostic Purposes [0.03%]
基于人工智能的超大规模虚拟筛选识别胆碱乙酰转移酶治疗诊断抑制剂
Anurag T K Baidya,Abhinav Kumar Goswami,Bhanuranjan Das et al.
Anurag T K Baidya et al.
Alzheimer's disease (AD) and related dementias are among the primary neurological disorders and call for the urgent need for early-stage diagnosis to gain an upper edge in therapeutic intervention and increase the overall success rate. Chol...
Fluoxetine Ameliorates Cognitive Deficits in High-Fat Diet Mice by Regulating BDNF Expression [0.03%]
氟西汀通过调节脑源性神经营养因子的表达改善高脂饮食小鼠的认知缺陷
Xiang Zuo,ZiKun Zhu,MengYu Liu et al.
Xiang Zuo et al.
High-fat diet (HFD) induced obesity is associated with depression-related behavioral and neurogenic changes and may lead to cognitive impairment. Fluoxetine (FXT), the most commonly used antidepressant, may alleviate depressive symptoms by ...
DNA-Mediated Formation of Phase-Separated Coacervates of the Nucleic Acid-Binding Domain of TAR DNA-Binding Protein (TDP-43) Prevents Its Amyloid-Like Misfolding [0.03%]
DNA介导的TAR DNA结合蛋白（TDP-43）核酸结合结构域分相类凝聚体的形成可防止其类似淀粉样蛋白的错误折叠
Divya Patni,Anjali D Patil,Mona S Kirmire et al.
Divya Patni et al.
Sequestration of protein molecules and nucleic acids to stress granules is one of the most promising strategies that cells employ to protect themselves from stress. In vitro, studies suggest that the nucleic acid-binding domain of TDP-43 (T...
Cholesterol Accelerates Aggregation of α-Synuclein Simultaneously Increasing the Toxicity of Amyloid Fibrils [0.03%]
胆固醇加速α-突触核蛋白聚集并增加淀粉样纤维的毒性
Mikhail Matveyenka,Abid Ali,Charles L Mitchell et al.
Mikhail Matveyenka et al.
A hallmark of Parkinson disease (PD) is a progressive degeneration of neurons in the substantia nigra pars compacta, hypothalamus, and thalamus. Although the exact etiology of irreversible neuronal degeneration is unclear, a growing body of...
Transcranial Alternating Current Stimulation: A Novel Neuromodulatory Treatment for Anxiety and Related Disorders [0.03%]
经颅交流电刺激：一种针对焦虑及相关障碍的新型神经调控治疗方法
Yahui Chen,Bicheng Gao,Yuqi You
Yahui Chen
Given the high prevalence and socioeconomic burden of anxiety disorders, there is an urgent need for effective, fast-acting, cost-efficient treatment alternatives to traditional psychotherapy. Transcranial alternating current stimulation (t...
Ultrasound Neuromodulation for Sleep and Neurological Disorder Therapy: A Path to Clinical Translation [0.03%]
用于睡眠和神经疾病治疗的超声波神经调节：临床转化之路
Hanming Zheng,Jiaru He,Greta S P Mok et al.
Hanming Zheng et al.
Ultrasound neuromodulation is a promising noninvasive technique capable of penetrating the skull and precisely targeting deep brain regions with millimeter accuracy. Recent studies have demonstrated that transcranial ultrasound stimulation ...
Element Changes Occurring in Brain Point at the White Matter Abnormalities in Rats Exposed to the Ketogenic Diet During Prenatal Life [0.03%]
脑元素变化提示生酮饮食暴露的母鼠后代出现白质异常
Marzena Rugieł,Zuzanna Setkowicz,Mateusz Czyzycki et al.
Marzena Rugieł et al.
A large number of clinical studies demonstrate that the ketogenic diet (KD) may be an effective approach to the reduction of epileptic seizures in children and adults. Such dietary therapy could also help pregnant women with epilepsy, espec...
Hypoxanthine Produces Rapid Antidepressant Effects by Suppressing Inflammation in Serum and Hippocampus [0.03%]
次黄嘌呤通过抑制血清和海马体内的炎症产生快速抗抑郁作用
Lei Wu,Jianhuai Chen,Qiao Yu et al.
Lei Wu et al.
The occurrence and development of depression are closely related to disorders of the brain and peripheral substances. Abnormal metabolites in the blood affect the signal regulation function of the nerve center, which is one of the key facto...