Unlocking the Potential of Oxymatrine: A Comprehensive Review of Its Neuroprotective Mechanisms and Therapeutic Prospects in Neurological Disorders [0.03%]
氧基麻黄碱的神经保护机制及其在神经系统疾病治疗前景的全面综述
Yogita Dhurandhar,Shubham Tomar,Ashmita Das et al.
Yogita Dhurandhar et al.
Sophora flavescens, the source of oxymatrine, is gaining popularity due to its potential in neuroprotection and treatment of various neurological conditions like epilepsy, depression, Parkinson's, Alzheimer's and multiple sclerosis. Its nat...
Ultrasensitive Detection of Blood-Based Alzheimer's Disease Biomarkers: A Comprehensive SERS-Immunoassay Platform Enhanced by Machine Learning [0.03%]
基于血液的阿尔茨海默病生物标志物超灵敏检测：机器学习增强型全面SERS免疫测定平台
A N Resmi,Shaiju S Nazeer,M E Dhushyandhun et al.
A N Resmi et al.
Accurate and early disease detection is crucial for improving patient care, but traditional diagnostic methods often fail to identify diseases in their early stages, leading to delayed treatment outcomes. Early diagnosis using blood derivat...
Identification and In Vitro and In Vivo Characterization of KAC-50.1 as a Potential α-Synuclein PET Radioligand [0.03%]
KAC-50.1的鉴定及其作为α-突触核蛋白PET示踪剂潜能的体内外表征研究
Dinahlee Saturnino Guarino,Patricia Miranda Azpiazu,Dan Sunnemark et al.
Dinahlee Saturnino Guarino et al.
The accumulation of aggregated α-synuclein (α-syn) is a pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Here within, we report the in vitro characterization targeting site 2 of α-syn fibrils and in vivo eva...
Aromatic Amino Acid Hydroxylases as Off-Targets of Histone Deacetylase Inhibitors [0.03%]
组蛋白去乙酰化酶抑制剂的芳香族氨基酸羟化酶脱靶效应
Anne Baumann,Niklas Papenkordt,Dina Robaa et al.
Anne Baumann et al.
The aromatic amino acid hydroxylases (AAAHs) phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylases 1 and 2 are structurally related enzymes that contain an active site iron atom and depend on tetrahydrobiopterin (BH4)...
Dexmedetomidine Attenuates Neuroinflammation-Mediated Hippocampal Neurogenesis Impairment in Sepsis-Associated Encephalopathy Mice through Central α2A-Adrenoceptor [0.03%]
右美托咪啶通过中枢α2A-肾上腺素能受体减轻神经炎症介导的全身性内毒素血症小鼠海马神经发生障碍作用及机制研究
Xinlong Zhang,Yue Feng,Yi Zhong et al.
Xinlong Zhang et al.
Sepsis-associated encephalopathy (SAE), one of the common complications of sepsis, is associated with higher ICU mortality, prolonged hospitalization, and long-term cognitive decline. Sepsis can induce neuroinflammation, which negatively af...
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion [0.03%]
SARS-CoV-2和HSV-1诱导人类脑脊液中的淀粉样蛋白聚集并导致可溶性蛋白质剧烈减少
Wanda Christ,Sebastian Kapell,Michal J Sobkowiak et al.
Wanda Christ et al.
The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological complications in patients, known as long COVID, have renewed interest in the correlation between viral infections and neurodegenerative brain disorders. While m...
L-DOPA Promotes Functional Proliferation Through GPR143, Specific L-DOPA Receptor of Astrocytes [0.03%]
多巴促进通过黑素皮质素受体4/GPR143实现的少突胶质前体的功能性增殖作用
Ye-Ji Kim,Gyeong Min Park,Woo Kyung Cho et al.
Ye-Ji Kim et al.
l-3,4-Dihydroxyphenylalanine (levodopa and L-DOPA in this text), alongside dopamine, boasts high biocompatibility, prompting industrial demand for its use as a coating material. Indeed, the effectiveness of L-DOPA is steadily rising as it s...
Novel Piperazine Based Compounds Target Alzheimer's Disease Relevant Amyloid β42 and Tau Derived Peptide AcPHF6, and the Lead Molecule Increases Viability in the Flies Expressing Human Tau Protein [0.03%]
新型哌嗪类化合物靶向阿尔茨海默病相关的淀粉样蛋白β42和tau衍生肽acphf6，先导分子可增加表达人类tau蛋白果蝇的存活率
Christopher Armstrong,Dan Luo,Anna Gretzinger et al.
Christopher Armstrong et al.
Alzheimer's disease (AD) is the leading form of dementia in the United States and the world. The pathophysiology of AD is complex and multifaceted. Accumulation of senile plaques and neurofibrillary tangles (NFTs) are hallmarks of AD. The a...
Fluorescence Detection and Inhibition Mechanisms of DNTPH on Aβ42 Oligomers Characterized as Products in the Four Stages of Aggregation [0.03%]
DNTPH对Aβ42寡聚体四阶段聚集产物的荧光检测及抑制机制研究
Mengke Jia,Ye Li,Chuanbo Wang et al.
Mengke Jia et al.
Aβ42 aggregation was implicated in the pathogenesis of Alzheimer's disease (AD) without effective treatment available currently. Future efforts in clinical trials should instead focus on applying those antiamyloid treatment strategies to t...
Rational Design, Synthesis, and Evaluation of Rofecoxib-Based Photosensitizers for the NIR Imaging and Photo-Oxidization of Aβ Aggregates [0.03%]
基于罗非考昔的用于近红外成像及Aβ聚集物光氧化的光敏剂的理性设计、合成与评价
Gulziba Anwar,Yingmei Cao,Wen-Jing Shi et al.
Gulziba Anwar et al.
The photo-oxidation of amyloid-β (Aβ) protein catalyzed by Aβ-targeting photosensitizers shows high potential in treating Alzheimer's disease (AD). Herein, we report the first example of photosensitizers based on the rofecoxib scaffold, ...