Exploring Cimetidine as a Potential Therapeutic Attenuator against Amyloid Formation in Parkinson's Disease: Spectroscopic and Microscopic Insights into Alpha-Synuclein and Human Insulin [0.03%]
西米替丁作为帕金森病潜在治疗减弱剂探究： alpha-突触核蛋白和人体胰岛素形成淀粉样物质的光谱学及显微镜研究见解
Md Nadir Hassan,Azeem Ahmad,Murtaza Hussain et al.
Md Nadir Hassan et al.
Neurodegenerative diseases, notably Alzheimer's and Parkinson's, hallmark their progression through the formation of amyloid aggregates resulting from misfolding. While current therapeutics alleviate symptoms, they do not impede disease ons...
Visualization of Unconjugated Bilirubin In Vivo with a Novel Approach Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging in a Rat Model [0.03%]
基于化学交换饱和转移磁共振成像技术的血管外胆红素活体可视化研究
Lin Yang,Yan Cheng,Yanlong Jia et al.
Lin Yang et al.
Unconjugated bilirubin (UCB) visualization is valuable for early bilirubin encephalopathy (BE) diagnosis and management. UCB neurotoxicity is a challenge, necessitating improved imaging modalities for precise localization and characterizati...
Joydip Das
Joydip Das
Alcohol use disorder (AUD) accounts for nearly 4.7% of all deaths and imposes a huge economic burden on society. Despite the magnitude of the problem, only a few Food and Drug Administration (FDA)/European Medicines Agency (EMA)-approved dr...
Detecting and Tracking β-Amyloid Oligomeric Forms and Dynamics In Vitro by a High-Sensitivity Fluorescent-Based Assay [0.03%]
一种高灵敏度荧光方法检测和追踪体外β-淀粉样寡聚形式及动态变化
Yanyan Zhao,Oleksandr Brener,Ewa Andrzejewska et al.
Yanyan Zhao et al.
Aggregation of β-amyloid protein is a hallmark pathology of the neurodegenerative disorder Alzheimer's disease and proceeds from monomers to insoluble misfolded fibril forms via soluble and highly toxic oligomeric intermediates. Given the ...
From Nutritional Patterns to Behavior: High-Fat Diet Influences on Inhibitory Control, Brain Gene Expression, and Metabolomics in Rats [0.03%]
从营养模式到行为：高脂肪饮食对大鼠抑制控制、脑基因表达和代谢组学的影响
Diego Ruiz-Sobremazas,Ana Cristina Abreu,Ángeles Prados-Pardo et al.
Diego Ruiz-Sobremazas et al.
Impulsive and compulsive behaviors are associated with inhibitory control deficits. Diet plays a pivotal role in normal development, impacting both physiology and behavior. However, the specific effects of a high-fat diet (HFD) on inhibitor...
Patent Review of Novel Biologics Targeting Opioid Use Disorder (2018-2024) [0.03%]
2018-2024年阿片类药物使用障碍新型生物制剂专利分析报告
Samuel Obeng,Lance R McMahon,Edward Ofori
Samuel Obeng
Drug overdose deaths in 2023 in the United States exceeded 107,000, with 80,000 of these deaths attributed to opioids alone. The emergence of synthetic opioids such as fentanyl and its analogues have worsened the opioid overdose epidemic. A...
Investigating the Mechanism of Neurotoxic Effects of PFAS in Differentiated Neuronal Cells through Transcriptomics and Lipidomics Analysis [0.03%]
采用转录组和脂质组分析研究PFAS对分化神经细胞神经毒性作用机制
Logan Running,Judith R Cristobal,Charikleia Karageorgiou et al.
Logan Running et al.
Per- and polyfluorinated alkyl substances (PFAS) are pervasive environmental contaminants that bioaccumulate in tissues and pose risks to human health. Increasing evidence links PFAS to neurodegenerative and behavioral disorders, yet the un...
Imidazo[2,1- b][1,3]thiazine Derivatives as Potential Modulators of Alpha-Synuclein Amyloid Aggregation [0.03%]
作为潜在的α-突触核蛋白淀粉样聚集调节剂的咪唑并[2,1-b][1,3]噻azine衍生物
Indrė Misiu Naitė,Kamilė Mikalauskaitė,Martyna Paulauskaitė et al.
Indrė Misiu Naitė et al.
Insoluble amyloid fibrils accumulate in the intercellular spaces of organs and tissues, leading to various amyloidosis-related disorders in the human body. Specifically, Parkinson's disease is associated with the aggregation of alpha-synucl...
Lipopolysaccharide Effects on Neurotransmission: Understanding Implications for Depression [0.03%]
脂多糖对神经传递的影响：理解其对抑郁的意义
L Batey,B Baumberger,H Khoshbouei et al.
L Batey et al.
Immune activation in the body is well studied; however, much less is known about how peripheral inflammation changes brain chemistry. Because depression and inflammation are close comorbidities, investigating how inflammation affects the br...
A VEGF Fragment Encompassing Residues 10-30 Inhibits Aβ1-42 Amyloid Aggregation and Exhibits Neuroprotective Properties Matching the Full-Length Protein [0.03%]
包含10-30位残基的VEGF片段可抑制Aβ1-42淀粉样蛋白聚集并表现出与全长蛋白质相当的神经保护特性
Stefania Zimbone,M Laura Giuffrida,Michele F M Sciacca et al.
Stefania Zimbone et al.
The intricate relationship between brain vascular diseases and neurodegeneration has garnered increased attention in the scientific community. With an aging population, the incidence of these two conditions is likely to increase, making it ...