Cellular Uptake of Tau Aggregates Triggers Disulfide Bond Formation in Four-Repeat Tau Monomers [0.03%]
细胞吸收tau聚集体引发四重复tau单体半胱氨酸残基形成二硫键
Brad J Krzesinski,Tyler J Holub,Zachariah Y Gabani et al.
Brad J Krzesinski et al.
Oxidative stress is an important driver of aging and has been linked to numerous neurodegenerative disorders, including Alzheimer's disease. A key pathological hallmark of Alzheimer's are filamentous inclusions made of the microtubule assoc...
Brazilin-Rich Extract from Caesalpinia sappan L. Attenuated the Motor Deficits and Neurodegeneration in MPTP/p-Induced Parkinson's Disease Mice by Regulating Gut Microbiota and Inhibiting Inflammatory Responses [0.03%]
巴西黄烷酮富集金鸡纳提取物通过调节肠道微生物和抑制炎症反应缓解1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP/p）诱导的小鼠帕金森病的运动缺陷和神经退行性病变
Wen Gao,Xinni Wu,Yang Wang et al.
Wen Gao et al.
Parkinson's disease (PD) is a complicated neurological disease with an unclear pathogenesis. However, dysregulation of gut microbiota and inflammation response play crucial roles in the progression of PD. Caesalpinia sappan L., a traditiona...
Opposite Roles of Cholesterol and Lanosterol in Lipid Membrane on Amyloid-Beta 42 Peptide Nucleation and Fibril Formation [0.03%]
胆固醇和羊毛固醇在脂质膜上对淀粉样β42肽原纤维的异相成核和聚集的相反作用
Kyohei Akiho,Akane Iida-Adachi,Hideki Nabika
Kyohei Akiho
Molecular self-assembly of amyloid-beta peptides to form fibrillar aggregates is a known cause of Alzheimer's disease. Although homogeneous nucleation of amyloid-beta is unfavorable, heterogeneous nucleation of amyloid-beta in cell membrane...
3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain [0.03%]
三维超分辨率成像揭示PSD95蛋白质复合物在小鼠脑中的分布及其浓度
Sam Daly,Edita Bulovaite,Anoushka Handa et al.
Sam Daly et al.
PSD95 is an abundant scaffolding protein that assembles multiprotein complexes controlling synaptic physiology and behavior. Confocal microscopy has previously shown that PSD95 is enriched in the postsynaptic terminals of excitatory synapse...
Polymeric Nanodiscs Comprising 5-Fluorouracil for Inhibition of Protein Aggregation and Their Anti-Alzheimer's Activity in the Drosophila Model [0.03%]
一种用于抑制蛋白聚集并具有抗阿尔茨海默活性的包含5-氟尿嘧啶的聚合物纳米圆盘
Pranita Rananaware,Seekha Naik,Lokanath Mishra et al.
Pranita Rananaware et al.
Nanoconjugates are promising for therapeutic drug delivery and targeted applications due to the numerous opportunities to functionalize their surface. The present study reports the synthesis of 5-fluorouracil (5-FU)-entrapped polyvinylpyrro...
Neurochemical and Morphological Comparisons of Motor Nerve Organoids and Spinal-Cord Explants [0.03%]
运动神经器官和脊髓移植片的神经化学和形态学比较研究
Shannon E Murphy,Amanda C Sullivan-Weiss,Chen H Sirois et al.
Shannon E Murphy et al.
Organoids are multicellular structures formed in vitro from populations of individual cells allowing modeling of structural and functional aspects of organs and tissues in normal and diseased states. They offer unique opportunities to model...
Comparative Study
ACS chemical neuroscience. 2025 Jan 1;16(1):30-39. DOI:10.1021/acschemneuro.4c00625 2025
Unraveling Copper Imbalance in Autism Spectrum Disorder: Mechanistic Insights from the Valproic Acid Mouse Model [0.03%]
自闭症光谱障碍中铜失衡的解析——戊酸盐小鼠模型中的机制研究
Weibo Ling,Weichao Wang,Dawei Lu et al.
Weibo Ling et al.
Abnormal copper (Cu) levels are often closely associated with neurological disorders including neurodevelopmental conditions, such as autism spectrum disorder (ASD). However, the mechanisms underlying the disruption of Cu homeostasis in cri...
Pilot Screening of TREM1 Inhibitors in Cell-Based Reporter Assays Reflecting TREM1/DAP12 Receptor Assembly and Functionality [0.03%]
基于反映TREM1/DAP12受体组装和功能性的报告基因测定的TREM1抑制剂筛选研究
Natalia Filippova,Roman Hromov,James Shi et al.
Natalia Filippova et al.
Proinflammatory TREM1 receptors expressed on myeloid-derived cells have recently been recognized as a new oncogenic target in cancer, including gliomas. They are established chemotherapeutic targets in neurodegenerative Parkinson's and Alzh...
S32, a Novel 3-Acetylaminocoumarin Compound, Exerts Neuroprotective Effects through the Inhibition of Neuroinflammation and Oxidative Stress In Vitro and In Vivo [0.03%]
新型化合物3-乙酰氨基香豆素(S32)通过体内外抑制神经炎症和氧化应激发挥神经保护作用
Xiao Zhang,Jiaqi Li,Jie Zhao et al.
Xiao Zhang et al.
Neuroinflammation and oxidative stress are key factors leading to neuronal injury. In this study, we investigated the role of S32, a novel 3-acetylaminocoumarin compound, in ameliorating neuronal injury induced by neuroinflammation and oxid...
Discovery of Dual Targeting GSK-3β/HIV-1 Reverse Transcriptase Inhibitors as Neuroprotective Antiviral Agents [0.03%]
GSK-3β/ HIV-1 逆转录酶双重抑制剂作为神经保护抗病毒制剂的研究发现
Thane Jones,Renuka Raman,Ana C Puhl et al.
Thane Jones et al.
Glycogen synthase kinase-3 beta (GSK-3β or GSK-3B) is a serine-threonine kinase involved in various pathways and cellular processes. Alteration in GSK-3β activity is associated with several neurological diseases including Alzheimer's dise...