Current Progress and Future Directions in Non-Alzheimer's Disease Tau PET Tracers [0.03%]
Tau PET示踪剂的研究进展及未来方向（非阿尔茨海默病）
Hendris Wongso,Ryuichi Harada,Shozo Furumoto
Hendris Wongso
Alzheimer's disease (AD) and non-AD tauopathies are dominant public health issues driven by several factors, especially in the aging population. The discovery of first-generation radiotracers, including [18F]FDDNP, [11C]PBB3, [18F]flortauci...
Correction to "Dexmedetomidine Attenuates Neuroinflammation-Mediated Hippocampal Neurogenesis Impairment in Sepsis-Associated Encephalopathy Mice through Central α2A-Adrenoceptor" [0.03%]
“右美托咪定通过中枢α2A-肾上腺素受体减轻神经炎症介导的全身性内毒素血症小鼠海马神经发生障碍”的校正通知
Xinlong Zhang,Yue Feng,Yi Zhong et al.
Xinlong Zhang et al.
Published Erratum
ACS chemical neuroscience. 2025 Jan 6. DOI:10.1021/acschemneuro.4c00805 2025
Salomé Coppens,Dea Gogishvili,Valentina Faustinelli et al.
Salomé Coppens et al.
Neurofilament light chain (NfL) is an early nonspecific biomarker in neurodegenerative diseases and traumatic brain injury, indicating axonal damage. This work describes the detailed structural characterization of a selected primary calibra...
Development and Evaluation in Rat and Monkey of a Candidate Homochiral Radioligand for PET Studies of Brain Receptor Interacting Protein Kinase 1: [18F](S)-1-(5-(3-Fluorophenyl)-4,5-dihydro-1 H-pyrazol-1-yl)-2,2-dimethylpropan-1-one [0.03%]
候选手性放射配体(S)-1-(5-(3-氟苯基)-4,5-二氢-1H-吡唑-1-基)-2,2-二甲基丙anone的制备及其在大鼠和猴子脑受体相互作用蛋白激酶1正电子发射断层扫描研究中的评价
Susovan Jana,Mudasir Maqbool,Xuefeng Yan et al.
Susovan Jana et al.
Receptor interacting protein kinase 1 (RIPK1) crucially upregulates necroptosis and is a key driver of inflammation. An effective PET radioligand for imaging brain RIPK1 would be useful for further exploring the role of this enzyme in neuro...
Jasmine Jade Butler,Sandrine Parrot,Chloé Aman et al.
Jasmine Jade Butler et al.
The exploration of increasingly specific brain structures and their relationships, in more nuanced ways, has facilitated the generation of databases for gene expression, connectivity, cell morphology, and electrophysiology. However, neuroch...
Insight into the Structure of the Neutral Amino Acid Transporter B0AT2 Enabled the Discovery of Tiagabine as an Inhibitor [0.03%]
天冬氨β-钠共转运蛋白的结构解析及筛选到的抑制剂替加滨
Jędrzej Kukułowicz,Agata Siwek,Małgorzata Wolak et al.
Jędrzej Kukułowicz et al.
The sodium-dependent membrane transporter SLC6A15 (B0AT2) belongs to the SLC6 family, which comprises carriers of amino acids and monoamines. B0AT2 is expressed in the central nervous system (CNS), including the glutaminergic and GABAergic ...
A Copper-Binding Peptide with Therapeutic Potential against Alzheimer's Disease: From the Blood-Brain Barrier to Metal Competition [0.03%]
一种具有治疗阿尔茨海默病潜力的铜结合肽：从血脑屏障到金属竞争作用
Victor E López-Guerrero,Yanahi Posadas,Carolina Sánchez-López et al.
Victor E López-Guerrero et al.
Alzheimer's disease (AD) is the most common form of dementia worldwide. AD brains are characterized by the accumulation of amyloid-β peptides (Aβ) that bind Cu2+ and have been associated with several neurotoxic mechanisms. Although the us...
Microstructural Degeneration of the Corpus Callosum in Parkinson's Disease with Unilateral Onset: A Free-Water Imaging Study [0.03%]
帕金森病单侧起病患者扣带回的微结构退变：自由水成像研究
Jingwen Chen,Jingjing Wu,Cheng Zhou et al.
Jingwen Chen et al.
Background: Motor symptom laterality is an important clinical feature of PD that not only manifests as lateral limb dysfunction but also affects the nonmotor symptoms and the prognosis in PD patients. Previous studies suggested that the com...
Competitive Antagonism of Xylazine on α7 Nicotinic Acetylcholine Receptors and Reversal by Curcuminoids [0.03%]
番泻醇竞争性抑制α7烟碱型乙酰胆碱受体及其用姜黄素类似物逆转作用研究
Qiang Chen,Yan Xu,Pei Tang
Qiang Chen
Co-use of xylazine with opioids is a major health threat in the United States. However, a critical knowledge gap exists in the understanding of xylazine-induced pharmacological and pathological impact. Xylazine is mostly known as an agonist...
Inhibition of Phosphorylated Alpha-Synuclein Aggregation by Synthetic Protein Mimetics and Foldamers [0.03%]
合成蛋白质模拟物和折纸分子对磷酸化α-突触核蛋白聚集的抑制作用
Emily G Oldani,Nicholas H Stillman,Ryan A Dohoney et al.
Emily G Oldani et al.
The formation of Lewy bodies (LB) is a pathological hallmark for synucleinopathies, which is an umbrella term for many diseases, including Parkinson's disease, Lewy body dementia, and multiple system atrophy. One of the main components of L...