Pravat K Mandal,Joseph C Maroon,Rimil Guha Roy et al.
Pravat K Mandal et al.
Alzheimer's disease (AD) impacts millions of elderly adults worldwide causing cognitive decline and severe deterioration of activities of daily life. The popular causal hypotheses for several decades include beta-amyloid (Aβ) deposition an...
Elevated BACE1 and IFNγ+ T Cells in Patients with Cognitive Impairment and the 5xFAD Mouse Model [0.03%]
伴有β淀粉样蛋白异常的认知障碍患者的BACE1和IFN-γ+T细胞的升高及5XFAD小鼠模型研究
Yaxi Zhan,Zuolong Chen,Shuxin Zheng et al.
Yaxi Zhan et al.
The dysregulation of T cell differentiation was associated with cognitive impairment. Recently, the peripheric β-secretase (BACE1) has been suggested as a regulator of T cell differentiation, which was increased in both cognitive impairmen...
Aluminum Induces Neurotoxicity through the MicroRNA-98-5p/Insulin-like Growth Factor 2 Axis [0.03%]
铝通过MicroRNA-98-5p/胰岛素样生长因子2轴诱导神经毒性
Chanting He,Qian Hu,Congying Liu et al.
Chanting He et al.
Aluminum is a well-known and widely distributed environmental neurotoxin. This study aimed to investigate the effect of miR-98-5p targeting insulin-like growth factor 2 (IGF2) on aluminum neurotoxicity. Thirty-two Sprague-Dawley rats were r...
Haipeng Wang,Hao He
Haipeng Wang
Targeted cell ablation is a powerful strategy for investigating the function of individual neurons within neuronal networks. Multiphoton ablation technology by a tightly focused femtosecond laser, with its significant advantages of noninvas...
Regulation of Dopamine Release by Tonic Activity Patterns in the Striatal Brain Slice [0.03%]
纹状体脑片中稳态活动模式对多巴胺释放的调节作用
Siham Boumhaouad,Emily A Makowicz,Sejoon Choi et al.
Siham Boumhaouad et al.
Voluntary movement, motivation, and reinforcement learning depend on the activity of ventral midbrain neurons, which extend axons to release dopamine (DA) in the striatum. These neurons exhibit two patterns of action potential activity: low...
From Plant to Pathway: Molecular Mechanisms of Ruscogenin in Preventing Amyloid-Beta Aggregation through Computational and Experimental Approaches [0.03%]
从植物到途径：通过计算和实验方法研究鲁斯可皂苷元预防淀粉样蛋白-β聚集的分子机制
Aastha Tiwari,Ravinder Singh,Shubham Kumar et al.
Aastha Tiwari et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, extracellular amyloid-β (Aβ) plaque accumulation, and intracellular neurofibrillary tangles. Recent efforts to find effective therapi...
Edaravone Improves Motor Dysfunction Following Brachial Plexus Avulsion Injury in Rats [0.03%]
依达拉奉改善臂丛神经撕脱伤后大鼠运动功能障碍
Sijing Li,Lin Wu,Juan Xie et al.
Sijing Li et al.
Brachial plexus root avulsion (BPRA) is often caused by road collisions, leading to total loss of motor function in the upper limb. At present, effective treatment options remain limited. Edaravone (EDA), a substance that eliminates free ra...
Application and Mechanism of Action of a Ketogenic Diet in Antiepileptic Therapy [0.03%]
生酮饮食在抗癫痫治疗中的应用及其作用机制
Chang Zhou,Shaogang Qu
Chang Zhou
Epilepsy is a chronic neurological disorder caused by abnormal discharges of neurons in the brain, which seriously affects the quality of life of patients. Although there are various drug treatments available, many epilepsy patients still e...
Istvan Horvath,Obed Akwasi Aning,Sriram Kk et al.
Istvan Horvath et al.
Amyloid fibrils are protein polymers noncovalently assembled through β-strands arranged in a cross-β structure. Biological amyloids were considered chemically inert until we and others recently demonstrated their ability to catalyze chemi...
Visualizing Endoplasmic Reticulum Stress and Autophagy in Alzheimer's Model Cells by a Peroxynitrite-Responsive AIEgen Fluorescent Probe [0.03%]
用于阿尔茨海默病模型细胞内质网应激和自噬可视化的一种过氧亚硝酸盐响应型AIE荧光探针
Lushan Huang,Liyi Ma,Qichen Zhu et al.
Lushan Huang et al.
Endoplasmic reticulum (ER) stress and autophagy (ER-phagy) occurring in nerve cells are crucial physiological processes closely associated with Alzheimer's disease (AD). Visualizing the two processes is paramount to advance our understandin...