Unlocking Neuroinflammation: A Balanced Art for Therapeutics of Prion Disease [0.03%]
解开神经炎症之锁：治疗朊病毒疾病的平衡艺术
Cao Chen,Xiaoping Dong
Cao Chen
Neuroinflammation plays a dual role in prion diseases, contributing both to the clearance of misfolded scrapie-like prion protein and to neuropathology through chronic activation of inflammatory pathways. Key mechanisms, including M-CSF/CSF...
Synthesis, Pharmacological Characterization, and Binding Mode Analysis of 8-Hydroxy-Tetrahydroisoquinolines as 5-HT7 Receptor Inverse Agonists [0.03%]
8-羟基四氢异喹啉作为5-HT7受体拮抗剂的合成、药理学特征及结合模式分析
Camilla B Chan,Eline Pottie,Icaro A Simon et al.
Camilla B Chan et al.
The serotonin 7 receptor (5-HT7R) regulates various processes in the central nervous system, including mood, learning, and circadian rhythm control, among others. Receptor activation can lead to activation of the Gαs protein and a subseque...
Targeted Metabolomics for the Analysis of p- Cresol in Mouse Brain: Impact of Biological Sex and Strain [0.03%]
靶向代谢组学在小鼠脑内p- cresol分析中的应用：性别和品系的影响
Laura Bertarini,Federico Imbeni,Antonietta Vilella et al.
Laura Bertarini et al.
p-Cresol, an environmental contaminant and endogenous metabolite derived primarily from the conversion of l-tyrosine by intestinal microflora, is gaining increasing attention, due to its potential impact on human health. Recent studies have...
Investigation of the Effects of Light, Darkness, and Dim Light on Rat Brain Tissue: A Biochemical and Histological Study [0.03%]
光、暗和昏暗光线对大鼠脑组织影响的调查：一项生化和组织学研究
Hıdır Pekmez,Tuğba Raika Kıran,Fahriye Seçil Tecelli Oğlu et al.
Hıdır Pekmez et al.
This study evaluates acetylcholinesterase (AChE) enzyme activity levels, oxidative stress parameters, histopathological findings, and serum melatonin levels in rat brain tissue. 32 male Wistar Albino rats were randomly divided into four gro...
Reactivity of Olanzapine and Tricyclic Antidepressants on the Protective Effects of Trolox on Lipid Peroxidation Evaluated Using Fluorescence Anisotropy, Electron Paramagnetic Resonance Spectrometry, and Thermal Analysis [0.03%]
奥氮平和三环类抗抑郁药对曲洛辛抗氧化作用的影响：荧光偏振、电子顺磁共振谱及热分析评价结果
Yusuke Horizumi,Reo Tanada,Yuya Kurosawa et al.
Yusuke Horizumi et al.
Multiacting receptor-targeting antipsychotics and tricyclic antidepressants stimulate various neurotransmitter receptors despite the different targets of postsynaptic receptors and presynaptic reuptake transporters. Their auxiliary and adve...
Novel Dual-Functional Half-Curcumin Analogues as a Fluorescent and PET Probe for β-Amyloid Imaging in the Alzheimer's Disease APP/PS1 Model [0.03%]
一种新型双功能半姜黄素类似物作为荧光和PET探针用于阿尔兹海默症APP/PS1模型中的β-淀粉样蛋白成像研究
Haijun Yang,Ke Li,Tingfang Wang et al.
Haijun Yang et al.
Noninvasive imaging of β-amyloid in vivo is pivotal for the early diagnosis of Alzheimer's disease (AD). While single imaging methods have been extensively studied for detecting Aβ over the past decade, dual-modal probes have received sca...
Determination of the Negative Allosteric Binding Site of Cannabidiol at the CB1 Receptor: A Combined Computational and Site-Directed Mutagenesis Study [0.03%]
结合计算和位点定向突变法确定大麻二酚在CB1受体上的负性别构结合位点
Pankaj Pandey,Ayat Zagzoog,Robert B Laprairie et al.
Pankaj Pandey et al.
Cannabinoid receptor 1 (CB1R) has been extensively studied as a potential therapeutic target for various conditions, including pain management, obesity, emesis, and metabolic syndrome. Unlike orthosteric agonists such as Δ9-tetrahydrocanna...
Cocaine-Induced Remodeling of the Rat Brain Peptidome: Quantitative Mass Spectrometry Reveals Anatomically Specific Patterns of Cocaine-Regulated Peptide Changes [0.03%]
定量质谱揭示脑肽组特征：定量质谱揭示可卡因调节肽的解剖学特异模式
Gaoyuan Lu,Fengfei Ma,Pingli Wei et al.
Gaoyuan Lu et al.
Addiction to psychostimulants, including cocaine, causes widespread morbidity and mortality and is a major threat to global public health. Currently, no pharmacotherapies can successfully treat psychostimulant addiction. The neuroactive eff...
Pravat K Mandal,Joseph C Maroon,Rimil Guha Roy et al.
Pravat K Mandal et al.
Alzheimer's disease (AD) impacts millions of elderly adults worldwide causing cognitive decline and severe deterioration of activities of daily life. The popular causal hypotheses for several decades include beta-amyloid (Aβ) deposition an...
Elevated BACE1 and IFNγ+ T Cells in Patients with Cognitive Impairment and the 5xFAD Mouse Model [0.03%]
伴有β淀粉样蛋白异常的认知障碍患者的BACE1和IFN-γ+T细胞的升高及5XFAD小鼠模型研究
Yaxi Zhan,Zuolong Chen,Shuxin Zheng et al.
Yaxi Zhan et al.
The dysregulation of T cell differentiation was associated with cognitive impairment. Recently, the peripheric β-secretase (BACE1) has been suggested as a regulator of T cell differentiation, which was increased in both cognitive impairmen...