Synthesis and Evaluation of Benzylic 18F-Labeled N-Biphenylalkynyl Nipecotic Acid Derivatives for PET Imaging of GABA Transporter 1 [0.03%]
苯乙基18F标记N-联苯炔基尼佩酸衍生物的合成与评价及其用于GABA转运蛋白1的PET显像研究
Niels Knippenberg,Matthias Bauwens,Alexandru Florea et al.
Niels Knippenberg et al.
As the main inhibitory neurotransmission system, the GABAergic system poses an interesting yet underutilized target for molecular brain imaging. While PET imaging of postsynaptic GABAergic neurons has been accomplished using radiolabeled be...
Molecular Insights into α-Synuclein Fibrillation: A Raman Spectroscopy and Machine Learning Approach [0.03%]
α-突触核蛋白纤维化分子机制的拉曼光谱与机器学习研究
Nathan P Coles,Suzan Elsheikh,Agathe Quesnel et al.
Nathan P Coles et al.
The aggregation of α-synuclein is crucial to the development of Lewy body diseases, including Parkinson's disease and dementia with Lewy bodies. The aggregation pathway of α-synuclein typically involves a defined sequence of nucleation, e...
Blocking the p38 MAPK Signaling Pathway in the Rat Hippocampus Alleviates the Depressive-like Behavior Induced by Spinal Cord Injury [0.03%]
阻断大鼠脊髓损伤后海马p38MAPK信号途径的传导缓解伤鼠抑郁行为
Zhiping Xie,Tianqi Xu,Jiwu Chen et al.
Zhiping Xie et al.
Patients with spinal cord injury (SCI) may develop depression, which can affect their rehabilitation. However, the underlying mechanism of depression in SCI patients remains unclear. Previous studies have revealed increased p38 MAPK phospho...
Subventricular Accumulation of Cu in the Aging Mouse Brain Does Not Associate with Anticipated Increases in Markers of Oxidative Stress [0.03%]
老年小鼠脑室下区的铜积累不伴随预期的氧化应激标志物增加
Ashley L Hollings,Gaewyn C Ellison,Meg Willans et al.
Ashley L Hollings et al.
Natural aging is associated with mild memory loss and cognitive decline, and age is the greatest risk factor for neurodegenerative diseases, such as Alzheimer's disease. There is substantial evidence that oxidative stress is a major contrib...
Computational Study of the Activation Mechanism of Wild-Type Parkin and Its Clinically Relevant Mutant [0.03%]
野生型PARKIN和临床相关突变型活化的机制计算研究
Zeynep Nur Cinviz,Ozge Sensoy
Zeynep Nur Cinviz
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. It impairs the control of movement and balance. Parkin mutations worsen the symptoms in sporadic cases and cause the early onset of the disease. Therefore, re...
m6A Demethylase FTO-Mediated Upregulation of BAP1 Induces Neuronal Ferroptosis via the p53/SLC7A11 Axis in the MPP+/MPTP-Induced Parkinson's Disease Model [0.03%]
FTO介导的BAP1上调通过p53/SLC7A11轴诱导脑内多巴胺能神经元铁死亡：美法仑/旋转哌啶诱导的帕金森病模型中的作用机制研究
Zhengyu Li,Xin Chen,Wenwen Xiang et al.
Zhengyu Li et al.
Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the involvement of ferroptosis in its pathological mechanism. In this study, the effects and mechanism of BRCA1-associated protein 1 (BAP1) on neuronal fe...
Panagiotis Mougkogiannis,Andrew Adamatzky
Panagiotis Mougkogiannis
This study examines the effects of incorporating serotonin (5-HT) into proteinoid microspheres. It looks at the microspheres' structure and electrochemical properties. Proteinoid-serotonin assemblies have better symmetry and membrane organi...
Rapid Microwave Fixation of the Brain Reveals Seasonal Changes in the Phosphoproteome of Hibernating Thirteen-Lined Ground Squirrels [0.03%]
快速微波固定大脑揭示了十三条线地鼠冬眠季节中磷蛋白组的变化
Md Shadman Ridwan Abid,Michael J Naldrett,Sophie Alvarez et al.
Md Shadman Ridwan Abid et al.
Hibernating mammals such as the thirteen-lined ground squirrel (Ictidomys tridecemlineatus) experience significant reductions in oxidative metabolism and body temperature when entering a state known as torpor. Animals entering or exiting to...
Hinokinin Decreases Methamphetamine-Induced Hyperlocomotion via the Regulatory Effects on Dopamine Levels [0.03%]
桧酸减少麻精拟交感胺诱发的过度活动通过调节多巴胺水平实现
Byoung Mo Choi,Sun Mi Gu,Abdulaziz Jabborov et al.
Byoung Mo Choi et al.
The global abuse of stimulant methamphetamine (METH) imposes a significant social burden. Despite this, effective therapeutic interventions for mitigating the harmful effects associated with METH-induced central nervous system (CNS) stimula...
Enhanced Analgesic Efficacy and Reduced Side Effects of Morphine by Combination with PD-1 Agonist [0.03%]
与PD-1激动剂联合使用可增强吗啡镇痛效力并减少不良反应
Xiaofei Song,Ying Zhang,Yuxin Liu et al.
Xiaofei Song et al.
Chronic pain is a debilitating disease and remains challenging to treat. Morphine serves as the most commonly used drug for the treatment of pathological pain. However, detrimental side effects (e.g., hyperalgesia and tolerance) manifest du...