Chemoproteomics Sheds Light on Epigenetic Targets of [11C]Martinostat in the Human Brain [0.03%]
化学蛋白质组学揭示[11C]马丁司他在人体大脑表观遗传靶点
Mary C Catanese,Yvonne E Klingl,Tonya M Gilbert et al.
Mary C Catanese et al.
Initiation of research programs to investigate binding specificity based on in vivo positron emission tomography (PET) imaging results can provide rich opportunities to improve data interpretation, gain biological insight, and inform hypoth...
Sapphire-Based Optrode for Low Noise Neural Recording and Optogenetic Manipulation [0.03%]
用于低噪声神经记录和光遗传操作的蓝宝石基光纤探针
Yanyan Xu,Ben-Zheng Li,Xinlong Huang et al.
Yanyan Xu et al.
Electrophysiological recording of neurons in deep brain regions using optogenetic stimulation is a powerful method for understanding and regulating the role of complex neural activity in biological behavior and cognitive function. Optogenet...
Muscle Matters: Transforming Amyotrophic Lateral Sclerosis Diagnostics with Next-Gen Biosensors and Smart Detection [0.03%]
肌有所属：下一代生物传感器和智能检测技术转化肌萎缩侧索硬化症的诊断
Saumitra Singh,Sameer Khan,Shina Khan et al.
Saumitra Singh et al.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that primarily targets the motor system, causing patients' speech and swallowing ability to rapidly deteriorate. Although ALS is usually classified into familia...
Electrochemical Sensing of Dopamine with an Implantable Microelectrode Array Microprobe Including an On-Probe Iridium Oxide Reference Electrode [0.03%]
包括探针式铱氧化物参比电极的可植入微电极阵列对多巴胺的电化学检测
Dmitriy A Ruckodanov,Nigel T Maidment,Harold G Monbouquette
Dmitriy A Ruckodanov
Inclusion of an on-probe iridium oxide (IrOx) reference electrode on an implantable microelectrode array (MEA) microprobe enabled dopamine (DA) sensing with high sensitivity, an ultralow limit of detection, and high selectivity against comm...
Exosomal PINK1 from Human Umbilical Cord Mesenchymal Stem Cells Attenuates Neurological Deficits and Inflammatory Responses after Intracerebral Hemorrhage in Mice [0.03%]
人脐带间充质干细胞源外泌体递送PINK1蛋白减轻ICH后神经功能缺损及炎症反应
Jianliang Li,Liang Yang,Lin Zhao et al.
Jianliang Li et al.
This study investigated the therapeutic potential of exosomes from human umbilical cord mesenchymal stem cells (huMSCs), focusing on PTEN-induced kinase 1 (PINK1) and its impact on exosome efficacy. Postmodification, exosomes were administe...
Quantitative Analysis of Neuropeptide Y (NPY) and C-Terminal Glycine-Extended NPY by Mass Spectrometry and Their Localization in the Developing and Sexual Adult Mouse Brains [0.03%]
定量分析神经肽Y(NPY)及其C末端甘氨酸延长型(NPY-Gly)并定位在小鼠发育和性成熟大脑中的分布情况
Tohru Yamagaki,Tomohiro Osugi,Yohei Shinmyo et al.
Tohru Yamagaki et al.
Neuropeptide Y (NPY), a central stimulator of food intake and an energy balance controlling hormone, was quantitatively analyzed in developing brains at birth using microflow liquid chromatography (LC) and triple-quadrupole tandem mass spec...
Acute Treatment with Salvianolic Acid A Produces Neuroprotection in Stroke Models by Inducing Excitatory Long-Term Synaptic Depression [0.03%]
急性给药丹参素A通过诱导兴奋性长时程突触抑制产生卒中模型神经保护作用
Jinnan Li,Niya Wang,Qi Huang et al.
Jinnan Li et al.
Acute ischemic stroke (AIS) is a significant brain disease with a high mortality and disability rate. Additional therapies for AIS are urgently needed, and neuroplasticity mechanisms by agents are expected to be neuroprotective for AIS. As ...
Ratiometric Imaging for Quantification of Elevated Ca2+ in Neurons Using Synthetic Low-Affinity Fluorescent Probe [0.03%]
基于合成低亲和力荧光探针的细胞内钙离子浓度的比率成像法检测技术
Yuzuka Kuronuma,Yutaka Shindo,Rei Kumada et al.
Yuzuka Kuronuma et al.
The availability of various calcium ion (Ca2+) fluorescent probes has contributed to revealing physiological events related to intracellular Ca2+. However, conventional probes face challenges for quantitatively and selectively visualizing h...
Distinct Aggregation Behavior of N-Terminally Truncated Aβ4-42 Over Aβ1-42 in the Presence of Zn(II) [0.03%]
N端截短的Aβ4-42与Aβ1-42聚集行为的差异及锌离子的影响
Chanju Na,Mingeun Kim,Gunhee Kim et al.
Chanju Na et al.
The deposition of amyloid-β (Aβ) aggregates and metal ions within senile plaques is a hallmark of Alzheimer's disease (AD). Among the modifications observed in Aβ peptides, N-terminal truncation at Phe4, yielding Aβ4-x, is highly preval...
Determination of Trends Underlying Aspartic Acid Isomerization in Intact Proteins Reveals Unusually Rapid Isomerization of Tau [0.03%]
完整蛋白质中天冬氨酸异构化的潜在趋势测定揭示了tau的异常快速异构化现象
Thomas A Shoff,Brielle Van Orman,Vivian C Onwudiwe et al.
Thomas A Shoff et al.
Spontaneous chemical modifications in long-lived proteins can potentially change protein structure in ways that impact proteostasis and cellular health. For example, isomerization of aspartic acid interferes with protein turnover and is ant...