Indolethylamine N-Methyltransferase Deletion Impacts Mouse Behavior without Disrupting Endogenous Psychedelic Tryptamine Production [0.03%]
色氨酸甲基化酶缺陷小鼠模型的行为表型及内源痕量胺N,N-二甲基色胺的分布研究
Cassandra J Hatzipantelis,Lindsay P Cameron,Min Liu et al.
Cassandra J Hatzipantelis et al.
Exogenously administered psychedelics produce both rapid and long-lasting effects on neuroplasticity and behavior, but it is currently unclear if endogenously produced psychedelics can elicit similar effects. There have been relatively few ...
Effects of Ethanol and Opioid Receptor Antagonists Naltrexone and LY2444296 on the Organization of Cholesterol- and Sphingomyelin-Enriched Plasma Membrane Domains [0.03%]
乙醇和阿片受体拮抗剂纳曲酮和LY2444296对富含胆固醇和鞘磷脂的质膜区域组织的影响
Sho Oasa,Wai H Mak,Adam L Maddox et al.
Sho Oasa et al.
Excessive consumption of alcohol (ethanol (EtOH)) can lead to alcohol use disorder (AUD). While AUD can be managed through behavioral interventions, there is a great need for pharmacological remedies for this condition. To date, only three ...
Modulation of Autism-Associated Serotonin Transporters by Palmitoylation: Insights into the Molecular Pathogenesis and Targeted Therapies for Autism Spectrum Disorder [0.03%]
棕榈酰化调节自闭症相关血清素转运蛋白：对自闭症分子发病机制及靶向治疗的见解
Christopher R Brown,James D Foster
Christopher R Brown
Autism spectrum disorder (ASD) is a developmental disorder of the nervous system characterized by a deficiency in interpersonal communication skills, a pathologic tendency for repetitive behaviors, and highly restrictive interests. The spec...
Targeting Glycolysis for Spinal Cord Injury: Regulatory Mechanisms and Therapeutic Prospects [0.03%]
脊髓损伤糖酵解治疗靶点：调控机制与前景展望
Shenghao Qian,Caizhen Shi,Bingbing Wang et al.
Shenghao Qian et al.
Spinal cord injury (SCI) is a severe neurological disorder that not only causes significant physical and psychological harm to patients but also imposes a substantial economic burden on families and society. Following SCI, a cascade of seco...
Quantitative Imaging of ATM: PET and Autoradiography Studies Using [11C]AZD1390 [0.03%]
使用[11C]AZD1390进行PET和自放射分析的ATM定量成像研究
Ramya Tokala,Chi-Hyeon Yoo,Joseph W Downey et al.
Ramya Tokala et al.
Ataxia-telangiectasia mutated (ATM) kinase plays a crucial role in DNA damage response and has emerged as a promising therapeutic target. AZD1390, an ATM kinase inhibitor developed by AstraZeneca, is currently in phase I clinical trials as ...
Histidine Focused Covalent Inhibitors Targeting Acetylcholinesterase: A Computational Pipeline for Multisite Therapeutic Discovery in Alzheimer's Disease [0.03%]
针对乙酰胆碱酯酶的组氨酸聚焦共价抑制剂治疗阿兹海默症的多重靶点计算研究流程
Sadia Jaman,Salsabil Fatima Tasmi,Imrul Shahriar et al.
Sadia Jaman et al.
Alzheimer's disease affects over 10% of individuals above the age of 65, yet current treatments offer only limited and temporary relief. Acetylcholinesterase, a key enzyme in neurotransmitter breakdown, also contributes to disease progressi...
Computationally Motivated Discovery of Biogenic Compounds with Potent CDK9 Inhibition and In Vitro Effects against Glioblastoma [0.03%]
计算启发的生物活性分子发现及其作为CDK9抑制剂和原发性胶质母细胞瘤作用的研究
Zahra R Khan,Philip J Welsby,Izabela Stasik et al.
Zahra R Khan et al.
Glioblastoma (GBM) is the most common malignant brain tumor in adults but with limited and poorly effective treatment protocols. Kinase inhibitors either as a mono- or as a combination therapy have considerable potential as novel treatments...
Deubiquitinating Enzyme UCH-L1 Regulates Neuronal Ca2+ Signaling [0.03%]
泛素羧基末端水解酶UCH-L1调节神经元Ca2+信号转导
Marie Perrier,Desirée Loreth,Johannes Brand et al.
Marie Perrier et al.
Ubiquitination influences a myriad of biological processes, such as the trafficking or degradation of ubiquitin-tagged target proteins. This posttranslational modification can be reversed by deubiquitinating enzymes (DUBs) that counterbalan...
Molecular Simulation-Based Insights into the Pharmacological Role of Silk Fibroin in Peripheral Nerve Repair [0.03%]
基于分子模拟的丝素蛋白在外周神经修复中的药理作用研究新见解
Nasser Alotaiq,Samir Chtita,Doni Dermawan
Nasser Alotaiq
Peripheral nerve injury (PNI) remains a significant clinical challenge, often leading to impaired nerve regeneration and chronic neuropathic pain. Can Si (Silk Fibroin), a key component of traditional Chinese medicine (TCM), has long been r...
Exogenous Huntingtin-Exon1 Aggregates Exhibit Distinct Levels of Toxicity to Caenorhabditis elegans [0.03%]
外源性亨廷顿蛋白第1外显子聚集体对秀丽隐杆线虫具有不同的毒性水平
Ephraim Ezeigbo,Kaitlyn Keith,Zachary L Ellis et al.
Ephraim Ezeigbo et al.
Many neurodegenerative diseases, including Alzheimer's (AD), Parkinson's (PD), and Huntington's disease (HD), are associated with proteinaceous deposits in the brain comprising amyloid. The aggregation process leading to these deposits proc...