Profiling the Impact of mGlu7/Elfn1 Protein Interactions on the Pharmacology of mGlu7 Allosteric Modulators [0.03%]
mGlu7/Elfn1蛋白相互作用对mGlusallosteric调节剂药理学的影响谱型分析
Xia Lei,Zixiu Xiang,Alice L Rodriguez et al.
Xia Lei et al.
The group III metabotropic glutamate receptors (mGlu receptors) are predominantly expressed presynaptically throughout the central nervous system (CNS) where they regulate the release of glutamate and GABA. These receptors have recently bee...
Tau Oligomers in Alzheimer's Disease: Modulation Effect of Osmolytes on Amplified Brain-Derived Tau Oligomers [0.03%]
阿尔茨海默病中的tau寡聚体：渗透调节剂对脑源性tau原纤维生长的调制作用
Sharif Arar,Md Anzarul Haque,Anas Kayed et al.
Sharif Arar et al.
Tau is bound to microtubules and plays a key role in their assembly and spatial organization. Under pathological conditions, tau detaches from the microtubules and develops a propensity to self-aggregate into soluble tau oligomers (TauO), p...
A Structure-Activity Relationship Study of Novel Positive Allosteric Modulators for the δ-Opioid Receptor [0.03%]
新型δ阿片受体阳性变构调节剂的构效关系研究
Owindeep Deo,Vi Pham,Sadia Alvi et al.
Owindeep Deo et al.
Chronic pain and depression are widely prevalent comorbid conditions with limited safe, yet effective treatments. While μ-opioid receptor (MOR) agonists are effective for treating pain, they are plagued with significant drawbacks, includin...
Exosomes and Their miRNA as a Potential Biomarker in the Diagnosis of Parkinson's Disease [0.03%]
外泌体及其miRNA作为诊断帕金森病的潜在生物标志物
Srilakshmi Vijayakumar,Beryl Vedha Yesudhason,Jenif Leo Anandharaj et al.
Srilakshmi Vijayakumar et al.
Exosomes are the smallest of the extracellular vesicles, essential in intercellular communication by transporting lipids, proteins, and RNA, thereby influencing the recipient cells. The exosomes from cerebrospinal fluid, central nervous sys...
Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned Media [0.03%]
一种新型双重作用机制的GRT-X激动剂通过作用于Kv7钾通道/转运蛋白受体来预防暴露于小鼠和人类肌萎缩侧索硬化症/额颞叶痴呆星形胶质细胞培养基后的运动神经元退变
Vera M Masegosa,Elsa Fritz,Daniela Corvalan et al.
Vera M Masegosa et al.
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) form a continuous spectrum of aggressive neurodegenerative diseases affecting primarily motoneurons (MNs) and cortical frontotemporal neurons. Noncell autonomous mechanis...
Can Oxytocin Neuropeptide Promote Human Mesenchymal Stem Cells to Neuron Conversion?: A Novel Approach in Future Neurotherapeutic Research [0.03%]
催产素神经肽可以促进人骨髓间充质干细胞向神经元转化吗？未来神经治疗研究的新方法
Pratikshya Paudel,Rahul Pandit Kumarchinchole,Prabir Kumar Gharai
Pratikshya Paudel
Neurodegenerative diseases are characterized by progressive neuronal loss, for which human mesenchymal stem cell (hMSC)-based therapies present a promising regenerative approach. Oxytocin, a neuropeptide known for its neuroprotective and an...
Crafting Precision: Design and Fabrication of a Xurography-Driven Microfluidic Platform for Exploring Neuron Culture and Targeted Drug Screening [0.03%]
精密化设计与制造：一种用于探索神经细胞培养及目标药物筛选的Xurography驱动式微流控平台
Subhadra Nandi,Satyajit Ghosh,Anindyasundar Adak et al.
Subhadra Nandi et al.
Over the past few decades, rapid advancements among in vitro cell culture models have come up as valuable assets in neurobiological research to understand the complexities of the human brain, disease development and progression at cellular ...
Well-Tempered Metadynamics Simulations Combined with Free Energy Landscape Analysis Uncover the Conformational Transition Pathway of the DYG Motif in LRRK2 [0.03%]
结合自由能景观分析的良 temperament 非平衡元动力学模拟揭示了 LRRK2 中 DYG 位点的构象转换路径
Xiaoqing Gong,Shuoyan Tan,Lingling Wang et al.
Xiaoqing Gong et al.
Leucine-rich repeat kinase 2 (LRRK2) is one of the most promising targets for the treatment of Parkinson's Disease. The activation of LRRK2 is regulated by the conserved Asp-Tyr-Gly (DYG) motif of the activation loop. Understanding the flip...
Shaon Joy,Tianxiong Mi,Rui-Liang Lyu et al.
Shaon Joy et al.
Neurotrophins (NTs, including NGF, BDNF, NT-4, and NT-3) are extracellular cytokines which modulate the survival and growth of cells expressing tropomyosin receptor kinases (Trks) A-C. Cells which express Trks include many neural tissues. F...
Psychedelics and the Gut Microbiome: Unraveling the Interplay and Therapeutic Implications [0.03%]
psychedelics和肠道微生物组：解开相互作用和治疗意义的秘密
Xue Wang,Fan Jun,Cong Lin et al.
Xue Wang et al.
Classic psychedelics and the gut microbiome interact bidirectionally through mechanisms involving 5-HT2A receptor signaling, neuroplasticity, and microbial metabolism. This viewpoint highlights how psychedelics may reshape microbiota and ho...