Corilagin Attenuates Neuronal Apoptosis and Ferroptosis of Parkinson's Disease through Regulating the TLR4/Src/NOX2 Signaling Pathway [0.03%]
通过调控TLR4/Src/NOX2信号通路，柯里拉京减轻帕金森病的神经元凋亡和铁死亡
Yu Lei,Jiabin Zhou,Dongyuan Xu et al.
Yu Lei et al.
Corilagin has shown neuroprotective potential in various neurological disorders, but its effects in Parkinson's disease (PD) have not been fully explored. In this study, we investigated the therapeutic impact and underlying mechanism of cor...
Effects of Transmembrane Phenylalanine Residues on γ-Secretase-Mediated Notch-1 Proteolysis [0.03%]
跨膜苯丙氨酸残基对γ-分泌酶介导的Notch-1水解的影响
Shweta R Malvankar,Michael S Wolfe
Shweta R Malvankar
γ-Secretase is a presenilin-containing intramembrane aspartyl protease complex that cleaves within the transmembrane domain (TMD) of nearly 150 substrates, with the amyloid precursor protein (APP) being the most well studied. APP cleavage ...
Neuroprotective Effect of Withaferin Derivatives toward MPP+ and 6-OHDA Toxicity to Dopaminergic Neurons [0.03%]
Withaferin衍生物对多巴胺能神经元MPP +和6-OHDA毒性的神经营护作用
Valeria Parrales,Guillaume Arcile,Louise Laserre et al.
Valeria Parrales et al.
Parkinson's disease is a neurodegenerative proteinopathy that primarily affects mesencephalic dopaminergic neurons. This dopaminergic depletion can be phenotypically reproduced in various experimental models through the administration of tw...
Tomas Fiala,David Sulzer,Dalibor Sames
Tomas Fiala
Measuring the transduction of electrical signals within neurons is a key capability in neuroscience. Fluorescent voltage sensitive dyes (VSDs) were early tools that complemented classical electrophysiology by enabling the optical recording ...
Acute Optogenetic Stimulation of Serotonin Neurons Reduces Cell Proliferation in the Dentate Gyrus of Mice [0.03%]
急性光遗传学刺激五羟色胺神经元可降低小鼠齿状回细胞增殖
Naozumi Araragi,Markus Petermann,Mototaka Suzuki et al.
Naozumi Araragi et al.
The dentate gyrus of the hippocampus is targeted by axons from serotonin raphe neurons, where the neurotransmitter modulates adult neurogenesis and antidepressant action, and mediates the neurogenic effect of running. Whether running-induce...
Sulfamerazine as a Potential Modulator against α-Synuclein Aggregation and Associated Toxicity [0.03%]
硫胺索辛作为α-突触核蛋白聚集和相关毒性的潜在调节剂
Priyanka Singh,Nagesh Y Kadam,Rajlaxmi Panigrahi et al.
Priyanka Singh et al.
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. The presence of Lewy bodies, primarily consisting of amyloid aggregates of the protein α-synuclein (α-Syn), is a common feature seen in dopaminergic neurons...
Discovery of a Novel Orally Active Ketamine Derivative with Dual Analgesic and Antidepressant Activities, Lacking Psychomimetic Effects [0.03%]
一种新型氯胺酮衍生物：兼具镇痛和抗抑郁作用且无致幻副作用口服活性药物的发现
Syed Muzzammil Masaud,Humaira Nadeem,Babar Murtaza et al.
Syed Muzzammil Masaud et al.
This study investigated the synthesis, characterization, and in silico analysis of novel N-acetamide ketamine derivatives aimed at evaluating their analgesic, anesthetic, and antidepressant properties. The synthesis commenced with the prepa...
Carnosine Mitigates Cognitive Impairment and Dopamine Release in an Okadaic Acid-Induced Zebrafish Model with Alzheimer's Disease-like Symptoms [0.03%]
半胱胺缓解斑马鱼阿尔茨海默病样模型的认知障碍和多巴胺释放缺陷作用机制研究
Hannah Chern,Giuseppe Caruso,Heather Desaire et al.
Hannah Chern et al.
Alzheimer's disease (AD), the leading cause of dementia, affects 1 in 9 people aged 65 and older. The disease impacts patients on multiple levels, from memory and problem-solving issues to difficulties with basic functions and personality c...
Microglial Autophagic Dysregulation in Traumatic Brain Injury: Molecular Insights and Therapeutic Avenues [0.03%]
创伤性脑损伤中微胶质自噬失调：分子见解和治疗途径
Nargis Bano,Sameera Khan,Shakir Ahamad et al.
Nargis Bano et al.
Traumatic brain injury (TBI) is a complex and multifaceted condition that can result in cognitive and behavioral impairments. One aspect of TBI that has received increasing attention in recent years is the role of microglia, the brain-resid...
HINT1 Inhibitors as Selective Modulators of MOR-NMDAR Cross-Regulation and Non-Opioid Analgesia [0.03%]
HINT1抑制剂作为选择性调节μ阿片受体与NMDA受体交叉调控和非阿片类镇痛的调控剂
Maxwell Dillenburg,Cristina D Peterson,Rafal Dolot et al.
Maxwell Dillenburg et al.
Human histidine triad nucleotide-binding protein 1 (HINT1) has recently become a protein of interest due to its involvement in several CNS processes, including neuroplasticity and the development of several neuropsychiatric disorders. Cruci...