Purinergic Receptor P2Y1 Modulates Catecholamine Signaling in Murine Mesenteric Lymph Nodes [0.03%]
鸟嘌呤核苷酸受体P2Y1调节鼠肠系膜淋巴结儿茶酚胺信号通路
Alexandra K Brooke,Sarbeshwar Ojha,Daniel P Murrow et al.
Alexandra K Brooke et al.
Neuroimmune communication is crucial for the body's response to physiological challenges, homeostasis, and immune stress response. Adrenergic and purinergic neurotransmission in the sympathetic nervous system is vital for this communication...
M4 Positive Allosteric Modulator VU0467154 Impacts Amphetamine Sensitization and Spontaneous Locomotion in Male Mice [0.03%]
M4正向变构调节器VU0467154对雄性小鼠的安非他敏敏感化和自发活动的影响
Anna Berezovskaia,Craig Lindsley,Anders Fink-Jensen et al.
Anna Berezovskaia et al.
This study investigates the effects of the muscarinic acetylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM) VU0467154 on the development, incubation, and expression of amphetamine sensitization in mice, the expression of...
Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound [0.03%]
ONO-2920632(VU6011887)的发现：一种高选择性、可渗透中枢神经系统的TREK-2（TWIK相关钾通道2）激活剂体内工具化合物
Kentaro Yashiro,Yuzo Iwaki,Hirohito Urata et al.
Kentaro Yashiro et al.
Herein we describe our initial work on the K2P family of potassium ion channels with the chemical optimization and characterization of a novel series of TWIK-Related K+ Channel (TREK)-1/2 dual activators and TREK-2 preferring activators der...
Optical Spectroscopy of Cerebral Blood Flow for Tissue Interrogation in Ischemic Stroke Diagnosis [0.03%]
用于组织检查的 cerebral blood flow 光学光谱术在诊断缺血性中风中的应用
Bakr Ahmed Taha,Ahmed C Kadhim,Ali J Addie et al.
Bakr Ahmed Taha et al.
Ischemic stroke remains a leading cause of morbidity and mortality worldwide, and early diagnosis is critical for improving clinical outcomes. This paper presents an optical design framework combining speckle contrast optical spectroscopy (...
Enhanced Cognitive and Memory Functions via Gold Nanoparticle-Mediated Delivery of Afzelin through Synaptic Modulation Pathways in Alzheimer's Disease Mouse Models [0.03%]
通过金纳米粒子介导的松黄茋传递增强阿尔茨海默病小鼠模型中的认知和记忆功能的过程研究
Ju Hee Mun,Min Jun Jang,Won Seok Kim et al.
Ju Hee Mun et al.
Gold nanoparticles (AuNPs) are valuable tools in pharmacological and biological research, offering unique properties for drug delivery in the treatment of neurodegenerative diseases. This study investigates the potential of gold nanoparticl...
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Restricts Inflammatory Progression through Limiting Macrophage Infiltration in DRG and Sciatic Nerve during Diabetic Peripheral Neuropathy [0.03%]
间脑星形胶质细胞源神经营养因子通过限制DRG和坐骨神经的巨噬细胞浸润来抑制糖尿病周围神经病变过程中的炎症进展
Peng Dai,Peng Wang,Xin Chen et al.
Peng Dai et al.
Diabetic peripheral neuropathy (DPN) is a prevalent complication affecting over half of individuals with diabetes. This study investigates the role of mesencephalic Astrocyte-derived neurotrophic factor (MANF) in DPN progression and its pot...
Dual GLP-1 and GIP Agonist Tirzepatide Exerted Neuroprotective Action in a Parkinson's Disease Rat Model [0.03%]
双重GLP-1和GIP受体激动剂Tirzepatide在帕金森病大鼠模型中展现出神经保护作用
Prashant Delvadia,Vipin Dhote,Avinash Singh Mandloi et al.
Prashant Delvadia et al.
Parkinson's disease (PD) is an age-related progressive disorder that leads to dopaminergic loss and subsequent motor dysfunction. Current therapies mainly deal with symptomatic effects, and hence, therapies targeting progressive neurodegene...
UPF 648, a Selective KMO Inhibitor, Attenuates Psychomotor and Cognitive Impairment in Chronic Kidney Disease [0.03%]
选择性KMO抑制剂UPF 648可减轻慢性肾病中的精神运动及认知障碍
Aparajita Ghosh,Neeraja Rayanki,Abhijeet R Joshi et al.
Aparajita Ghosh et al.
Kynurenine-3-monooxygenase (KMO), a key enzyme in the kynurenine pathway (KP) of tryptophan metabolism, converts kynurenine into the neurotoxic intermediate quinolinic acid (QA). QA, an N-methyl-d-aspartate (NMDA) receptor agonist, increase...
Anterior Cingulate Cortex-Anterior Insular Cortex Circuit Mediates Hyperalgesia in Adolescent Mice Experiencing Early Life Stress [0.03%]
前扣带皮层-前岛皮层回路介导经历早期生活压力的小鼠的痛觉过敏反应
Meng Li,Kefang Liu,Mingyu Xu et al.
Meng Li et al.
Understanding neurobiological mechanisms underlying changes in behavior and neural activity caused by early life stress (ELS) is essential for improving these adverse outcomes in individuals. ELS incited by exposure to maternal separation (...
Corilagin Attenuates Neuronal Apoptosis and Ferroptosis of Parkinson's Disease through Regulating the TLR4/Src/NOX2 Signaling Pathway [0.03%]
通过调控TLR4/Src/NOX2信号通路，柯里拉京减轻帕金森病的神经元凋亡和铁死亡
Yu Lei,Jiabin Zhou,Dongyuan Xu et al.
Yu Lei et al.
Corilagin has shown neuroprotective potential in various neurological disorders, but its effects in Parkinson's disease (PD) have not been fully explored. In this study, we investigated the therapeutic impact and underlying mechanism of cor...