Fluorescent Sensor for the Visualization of Amino Acid Neurotransmitters in Neurons Based on an SNAr Reaction [0.03%]
基于SNAr反应可视化神经元中的氨基酸类神经递质的荧光传感器
Ming Xu,Peeyush Yadav,Xin Liu et al.
Ming Xu et al.
Glutamate is an important excitatory neurotransmitter, while GABA is an inhibitory neurotransmitter. However, direct and accurate visualization of these important signaling agents by a chemical sensor is still very challenging. Here, a nove...
Radiosynthesis, In Vitro Characterization, and In Vivo PET Neuroimaging of [18F]F-4 for Tau Protein: A First-in-Human PET Study [0.03%]
[18F]F-4的放化合成，体外特性分析以及体内PET神经影像在人Tau蛋白成像中的应用：一项首次人类PET研究
Anton Lindberg,Junchao Tong,Chao Zheng et al.
Anton Lindberg et al.
[18F]PI-2620 is a promising radiopharmaceutical for positron emission tomography (PET) imaging of both Alzheimer's disease (AD) and non-Alzheimer's disease (non-AD) tauopathies in humans. An array of fluorinated derivatives of the carbazole...
The Use of Natural Volatile Compounds on the Fibrillation Domain of Amyloid Beta (GSNKGAIIGLM)─Towards Promising Agents to Combat Alzheimer's Disease [0.03%]
天然挥发性化合物在淀粉样蛋白贝塔（GSNKGAIIGLM）纤维化域上的应用──对抗阿尔茨海默病的潜在有效物质
Zahra Dindar,Afrooz Anbaraki,Seyyed Sina Hosseini et al.
Zahra Dindar et al.
Alzheimer's disease (AD), which is caused by the accumulation of amyloid-beta, is a major medical concern today. Controlling these aggregates is critical to drug development, but delivering them effectively into the bloodstream poses signif...
Mikhail Matveyenka,Mikhail Sholukh,Dmitry Kurouski
Mikhail Matveyenka
Alzheimer's disease (AD) is a progressive pathology that is linked to abrupt aggregation of amyloid β1-42 (Aβ1-42) peptide in the central nervous system. Aβ1-42 aggregation yields amyloid oligomers and fibrils, toxic protein aggregates t...
Dysregulated Neurotransmission and the Role of Viruses in Alzheimer's Disease [0.03%]
失调的神经传导及病毒在阿尔茨海默病中的作用
Katherine Bovis,Martha Davies-Branch,Philip J R Day
Katherine Bovis
The causes of neurodegeneration remain elusive. There is growing evidence linking viral infection to dysregulated neurotransmission as a causative factor in Alzheimer's disease. Studies suggest that viral infection may result in dysregulate...
Evaluating the Molecular Interactions between Type 2 Diabetes Mellitus and Parkinson's Disease: Role of Antidiabetic Drugs as Promising Therapeutics [0.03%]
2型糖尿病和帕金森病之间的分子相互作用评估：抗糖尿病药物作为潜在治疗药物的作用
Irum Waheed,Talal Sikandri,Sumbal Zaheen et al.
Irum Waheed et al.
Evidence from previous research demonstrates a relationship between diabetes mellitus (DM) and Parkinson's disease (PD). T2DM is associated with chronic glucose dysregulation, as an etiological factor. It inhibits neuronal function through ...
Determinants for Substoichiometric Inhibition of IAPP and Aβ Amyloid Aggregations by Bri2 BRICHOS [0.03%]
Bri2 BRICHOS对IAPP和Aβ淀粉样聚合的次计量抑制的决定因素
Zhenzhen Zhang,Gangtong Huang,Shivani Gupta et al.
Zhenzhen Zhang et al.
Bri2 BRICHOS, a folded domain of the transmembrane protein Bri2 expressed in both the brain and pancreas, is an experimentally known substoichiometric inhibitor of amyloid aggregation. The molecular chaperone effectively delays fibrillizati...
Monoamine Oxidase Inhibitors Present in Tobacco Modulate Dopamine Balance Via the Dopamine Transporter [0.03%]
烟草中存在的单胺氧化酶抑制剂通过多巴胺转运蛋白调节多巴胺平衡
Gabriella Saro,Stephanie Johne,Diogo A R S Latino et al.
Gabriella Saro et al.
It has been reported that nicotine affects brain dopamine homeostasis. By binding to nicotinic acetylcholine receptors, including those expressed by dopaminergic neurons of the ventral tegmental area, nicotine stimulates dopamine release an...
SCN8A Epileptic Encephalopathy Mutation Displays a Loss-of-Function Phenotype and Distinct Insensitivity to Valproate [0.03%]
SCN8A癫痫性脑病突变表现出功能丧失的表型以及对丙戊酸的不同敏感度
Yudan Zhu,Guangfei Wang,Kaixuan Wang et al.
Yudan Zhu et al.
Voltage-gated sodium channels are the main targets of antiepileptic drugs, such as sodium valproate (VPA). Single nucleotide polymorphisms (SNPs) in the Nav1.6 isoform (SCN8A) have been reported to be closely associated with motor dysfuncti...
Acridine Benzimidazolium Derivatives Induced Protective Microglia Polarization and In Silico TDP-43 Interaction─Potential Implications for Amyotrophic Lateral Sclerosis [0.03%]
吖啶苯并咪唑衍生物诱导的保护性小胶质细胞极化及计算模拟TDP-43相互作用─可能对肌萎缩侧索硬化症有潜在意义
Neeraja Revi,Muneshwar Nandeshwar,Dinesh Harijan et al.
Neeraja Revi et al.
Abnormal protein aggregation and associated neuronal-glial cell cytotoxicity lead to a plethora of neurodegenerative disorders. Most of the earlier investigations on understanding neurodegenerative disease progression and cure focused on ne...