Gabriel Cathoud,Mohtadin Hashemi,Yuri Lyubchenko et al.
Gabriel Cathoud et al.
Alzheimer's disease is characterized by the accumulation of amyloid plaques in the brain. Recent studies suggest that amyloid-β (Aβ) peptides interact with cell membranes, potentially catalyzing plaque formation. However, the effect of va...
Troglitazone as a Novel Nrf2 Activator to Attenuate Oxidative Stress and Exert Neuroprotection [0.03%]
丙吡胺作为Nrf2激活剂的新用途：减轻氧化应激和发挥神经保护作用
Linjie Zhang,Shuang Wang,Yanxia Zhang et al.
Linjie Zhang et al.
Nuclear factor erythroid 2 related factor 2 (Nrf2) is closely associated with neurodegenerative diseases, and the Nrf2-mediated activation of antioxidant response elements (AREs) brings about validated strategies for treating neurodegenerat...
Application of Deuterium in an M1 Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422 [0.03%]
氘在M1正同种型调节物备用项目中的应用：VU6045422的发现
Julie L Engers,Jinming Li,Changho Han et al.
Julie L Engers et al.
Recently, we disclosed VU0467319, an M1 positive allosteric modulator (PAM) clinical candidate that had successfully completed a phase I single ascending dose clinical trial. Pharmacokinetic assessment revealed that, in humans upon increasi...
Preclinical Profile of CM699 as a Medication Candidate for Stimulant Use Disorder [0.03%]
CM699作为刺激物使用障碍药物候选药物的临床前特征
Takato Hiranita,Weimin C Hong,Abhisheak Sharma et al.
Takato Hiranita et al.
There currently are no medications proven to be effective for the treatment of stimulant-use disorder (SUD). Sigma-receptor (σR) antagonists block many effects of stimulant drugs but not the reinforcing effects assessed with self-administr...
Activation of Cytosolic Cathepsin B Activity in the Brain by Traumatic Brain Injury and Inhibition by the Neutral pH Selective Inhibitor Probe Z-Arg-Lys-AOMK [0.03%]
创伤性脑损伤激活脑细胞质中的组织蛋白酶B活性以及被中性pH选择性抑制剂Z-Arg-Lys-AOMK的抑制作用
Sonia Podvin,Jazmin Florio,Brian Spencer et al.
Sonia Podvin et al.
Cathepsin B has been shown to contribute to deficits in traumatic brain injury (TBI), an important risk factor for Alzheimer's disease (AD). Cathepsin B is elevated in TBI and AD patients, as well as in animal models of these conditions. Kn...
Morphine-Induced Antinociception Is Potentiated and Dopamine Elevations Are Inhibited by the Biased Kappa Opioid Receptor Agonist Triazole 1.1 [0.03%]
偏向性κ阿片受体激动剂Triazole 1.1增强吗啡诱导的镇痛并抑制多巴胺水平升高
Emanuel F Lopes,Alyssa M West,Jason L Locke et al.
Emanuel F Lopes et al.
Traditional analgesic opioid compounds, which act through μ opioid receptors (MORs), engender a high risk for misuse and dependence. κ opioid receptor (KOR) activation, a potential target for pain treatment, produces antinociception witho...
Interplay of Endoplasmic Reticulum Stress, Inflammation, Apoptosis, and Oxidative Stress in Corticosteroid-Induced Anxiety and Depression: Exploring Therapeutic Potential of Hydrogen Sulfide and Sertraline [0.03%]
内质网应激，炎症，凋亡和氧化应激在皮质类固醇诱导的焦虑和抑郁中的相互作用：探索硫化氢和舍曲林的治疗潜力
May A Azzam,Asmaa A ElMonier,Enas S Gad et al.
May A Azzam et al.
Prolonged exposure to corticosteroids (CORTs) triggers depression and anxiety symptoms either endogenously or exogenously via stimulating endoplasmic reticulum stress (ERS). The study assessed the therapeutic implications of hydrogen sulfid...
Upregulation of the PI3K/AKT and Nrf2 Pathways by the DPP-4 Inhibitor Sitagliptin Renders Neuroprotection in Chemically Induced Parkinson's Disease Mouse Models [0.03%]
DPP-4抑制剂Sitagliptin通过上调PI3K/AKT和Nrf2通路使化学诱导的帕金森病小鼠模型产生神经保护作用
Ritu Soni,Vaishali Pankaj,Sudeep Roy et al.
Ritu Soni et al.
Parkinson's disease (PD) is one of the most common progressive neurodegenerative pathologies that leads to dopaminergic deficiency and motor manifestations. Alpha-synuclein aggregation is a characteristic hallmark of PD pathogenesis. These ...
Development of Donor-Acceptor Architecture-Based Potential Theranostic Fluorescent Probes for Alzheimer's Disease [0.03%]
受体供体架构为基础的潜在治疗诊断荧光探针在阿尔茨海默病中的发展
Nilesh Gajanan Bajad,Gajendra T A,Khushboo Sharma et al.
Nilesh Gajanan Bajad et al.
The cholinergic deficits and deposition of β-amyloid (Aβ) species are regarded as the key events contributing to the progression of Alzheimer's disease (AD). Herein, a series of novel donor-acceptor architecture-type potential theranostic...
The Neurochemical Signature of Cardiac Arrest: A Multianalyte Online Microdialysis Study [0.03%]
心脏停搏的神经化学特征：一种多分析物在线微透析研究
C Cicatiello,S A N Gowers,G K Smith et al.
C Cicatiello et al.
This work describes the use of high resolution online microdialysis coupled with a wireless microfluidic electrochemical sensing platform for continuous monitoring of the effect of cardiac arrest and resuscitation methods on brain glucose a...