A Systematic Review Focusing on the Link between Engineered Nanoparticles and Neurodegeneration [0.03%]
聚焦于纳米粒子与神经退行性疾病关系的系统性综述
Carlo Manco,Delia Righi,Sara Locci et al.
Carlo Manco et al.
Engineered nanoparticles (ENPs) have widely revolutionized many fields, including medicine, technology, environmental science, and industry. However, with the wide use of ENPs in everyday life, concerns are increasingly being raised about t...
Quinazolinone Acrylamides as Multifunctional Anti-Alzheimer Agents: Unraveling their Modulating Efficacy on Amyloidogenic Peptide Assembly at the Molecular Level [0.03%]
喹唑啉酮丙烯酰胺类多靶点抗阿尔茨海默化合物：通过分子模拟阐明其调节淀粉样肽组装的效能
Kandrakonda Yelamanda Rao,Remya Chandran,Dileep K V et al.
Kandrakonda Yelamanda Rao et al.
Amyloid β peptide (Aβ) aggregation in the brain represents an initial detrimental episode in the etiology of Alzheimer's disease (AD). Recently, it has been discovered that inhibiting Aβ neurotoxicity by modulating highly toxic Aβ oligo...
Yue Sun,Hu Shi
Yue Sun
Protein folding is crucial as it determines the three-dimensional structure and function of proteins, which are essential for biological processes, while misfolding can lead to the formation of aggregates and dysfunctional proteins, often a...
Caffeine and Nicotine with N-Substituted Diazirine Photoaffinity Labels Form Adducts at Tyrosine-39 of α-Synuclein [0.03%]
咖啡因和尼古丁通过N-取代叠氮
Melissa Mejia-Gutierrez,Brigitte Moser,Marissa Pirlot et al.
Melissa Mejia-Gutierrez et al.
Aggregates of the protein α-synuclein are found in Lewy bodies in the brains of Parkinson's disease (PD) patients. Small molecules that can attenuate or halt α-synuclein aggregation have been studied as potential therapeutics for PD. Howe...
Biophysical Characterization and Preformulation Studies of Human Mesencephalic Astrocyte-Derived Neurotropic Factor [0.03%]
人脑黑质星形胶质细胞源性神经营养因子的生物物理表征及预制剂研究
Robert W Payne,Tiansheng Li,Albert Li et al.
Robert W Payne et al.
A novel neurotrophic factor, human mesencephalic astrocyte-derived neurotrophic factor (hMANF), is being considered a therapeutic agent for a variety of diseases. However, little, if anything, has been reported about its stability. A prefor...
Cross-Interaction with Amyloid-β Drives Pathogenic Structural Transformation within the Amyloidogenic Core Region of TDP-43 [0.03%]
与淀粉样蛋白-β的相互作用驱动TDP-43淀粉样核心区域的病理结构转变
Adam J Gatch,Feng Ding
Adam J Gatch
Alzheimer's disease (AD) is the world's most prevalent neurodegenerative disorder, characterized neuropathologically by senile plaques and neurofibrillary tangles formed by amyloid-β (Aβ) and tau, respectively. Notably, a subset of AD pat...
Toward a Small-Molecule Antagonist Radioligand for Positron Emission Tomography Imaging of the Mu Opioid Receptor [0.03%]
用于μ型阿片受体正电子发射断层成像的小分子拮抗放射性配基研究
Konstantinos Plakas,Chia-Ju Hsieh,Dinahlee Saturnino Guarino et al.
Konstantinos Plakas et al.
The opioid crisis is a catastrophic health emergency catalyzed by the misuse of opioids that target and activate the mu opioid receptor. Many traditional radioligands used to study the mu opioid receptor are often tightly regulated owing to...
Calycosin Inhibit PANoptosis and Alleviate Brain Damage: A Bioinformatics and Experimental Verification Approach [0.03%]
花旗松素抑制PANoptosis并减轻脑损伤：一种生物信息学和实验验证方法
Huiyan An,Chongyu Shao,Yu He et al.
Huiyan An et al.
PANoptosis is a newly identified form of cell death that encompasses pyroptosis, apoptosis, and necroptosis. Numerous studies have highlighted the significance of PANoptosis in brain ischemia-reperfusion (I/R) injury. Calycosin, a natural p...
Brain Metabolite Profiles are Associated with Selective Neuronal Vulnerability and Underlying Mechanisms in Amyotrophic Lateral Sclerosis [0.03%]
肌萎缩性侧索硬化中选择性神经元易损性和其潜在机制相关的脑代谢物谱分析
Enam Alhagh Gorgich,Zahra Heidari,Hamidreza Mahmoudzadeh-Sagheb et al.
Enam Alhagh Gorgich et al.
Amyotrophic lateral sclerosis (ALS) is a lethal neurological syndrome accompanied by selective degeneration of somatic motor neurons and neurochemistry alterations. Nevertheless, eye movement's nuclei are relatively spared from ALS damage. ...
Induction of Ferroptotic Cell Death by Neuromelanin Pigments in Dopaminergic Cells [0.03%]
神经黑色素在多巴胺能细胞中诱导铁死亡性细胞死亡
Gizem Kaftan Öcal,Güliz Armagan
Gizem Kaftan Öcal
Neuromelanin (NM) is an iron-rich, insoluble brown or black pigment that exhibits protective properties. However, its accumulation over time may render it a source of free radicals. In Parkinson's disease, dopaminergic neurons with the high...