Multi-Frequency Interpolation X-talk Removal Algorithm: Enabling Combinations of Concurrent Optogenetics and Lock-in Amplification Fiber Photometry via Removal of Optogenetic Stimulation Crosstalk [0.03%]
多频插值交叉谈话消除算法：通过移除光遗传学刺激交叉对话实现并发光遗公和锁相放大光纤光电计量
Maxim Breakstone,Spencer C Chen,Sreya Vadapalli et al.
Maxim Breakstone et al.
Simultaneous fiber photometry and optogenetics is a powerful emerging technique for precisely studying the interactions of neuronal brain networks. However, spectral overlap between photometry and optogenetic components has severely limited...
Urolithin-A Derivative UAS03 Improves Cognitive Deficits and Memory by Activating Nrf2 Pathways to Alleviate Oxidative Stress and Neuroinflammation [0.03%]
尿石素A衍生物UAS03通过激活Nrf2通路缓解氧化应激和神经炎症来改善认知障碍和记忆力损伤
Dipan Maity,Vikrant Rahi,Sandya Tambi Dorai et al.
Dipan Maity et al.
Neuroinflammation is a key factor in age-related cognitive decline and memory impairment. UAS03, a potent synthetic analogue of Urolithin-A, has demonstrated anti-inflammatory and antioxidant properties. This investigation examined the neur...
4-Amino-3',4'-dihydroxychalcone Increases Tau Dynamics in Phase-Separated Droplets and Inhibits Tau Aggregation [0.03%]
4-氨基-3',4'-二羟基查耳酮增加tau在相分离液滴中的动态并抑制tau聚集
Rajeshkumar S Gop,Rishav Adhikary,Anuradha Venkatramani et al.
Rajeshkumar S Gop et al.
The aggregation of the microtubule-associated protein tau is a distinctive characteristic of several neurodegenerative disorders like Alzheimer's disease and frontotemporal dementia. Small-molecule inhibitors have been investigated as a pot...
Combining Metabolomics and Quantitative Analysis to Investigate Purine Metabolism Disorders in Depression and the Therapeutic Effect of Chaigui Granules [0.03%]
代谢组学与定量分析联合探讨抑郁症嘌呤代谢紊乱及柴桂颗粒的治疗效应
Dehua Huang,Jiale Lv,Wenxia Gong et al.
Dehua Huang et al.
Depression is a complex mental disorder. Studies have shown that purine metabolism disorders in depression and regulation of purine metabolites and related purinergic receptors may be an effective way to alleviate depression. Chaigui granul...
Neuroprotective and Anti-inflammatory Dual-Phenotypic Drug Screening Strategies [0.03%]
神经保护和抗炎双重表型药物筛选策略
Xue-Hui Liu,Hong-Yuan Liu,Jing Gu et al.
Xue-Hui Liu et al.
Traditional drug development, which predominantly focuses on single target/phenotype evaluation, often fails to achieve optimal therapeutic outcomes in multifactorial and multitarget conditions like ischemia-reperfusion injury. In this view...
Anti-inflammatory and Antioxidant Effects of Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Derived from Mesenchymal Stem Cells on Parkinson's Disease [0.03%]
间充质干细胞衍生的小细胞外囊泡的抗炎和抗氧化作用对帕金森病的影响
Ling Hu,Shaogang Qu
Ling Hu
Oxidative stress and neuroinflammation can synergistically accelerate dopaminergic neuronal degeneration in Parkinson's disease (PD). Small extracellular vesicles derived from mesenchymal stem cells (MSC-sEVs) inhibit Nox4/ROS production by...
Potential Therapeutic Effects of Terahertz Radiation on Alzheimer's Disease-like Pathology in the Tau Transgenic Caenorhabditis elegans Model [0.03%]
太赫兹辐射对tau转基因秀丽隐杆线虫模型中阿尔茨海默病样病理的潜在治疗作用
Sen Shang,Xiaofei Zhao,Qi Zhang et al.
Sen Shang et al.
The application of terahertz waves in the field of neurological disease research has gradually attracted attention in recent years. Prior studies have indicated that terahertz waves are capable of alleviating the symptoms of Alzheimer's dis...
Interplay of Neuroinflammation and Gut Microbiota Dysbiosis in Alzheimer's Disease Using Diffusion Kurtosis Imaging Biomarker in 3 × Tg-AD Mouse Models [0.03%]
利用扩散张量成像生物标志物探讨小胶质细胞活化和肠道菌群失调在3×Tg-AD小鼠模型中的交互作用关系研究阿尔兹海默病
Lalitha Palanivelu,Ching-Wen Chang,Ssu-Ju Li et al.
Lalitha Palanivelu et al.
The relationship between alterations in brain microstructure and dysbiosis of gut microbiota in Alzheimer's disease (AD) has garnered increasing attention, although the functional implications of these changes are not yet fully elucidated. ...
Discovery and Characterization of Novel Receptor-Interacting Protein Kinase 1 Inhibitors Using Deep Learning and Virtual Screening [0.03%]
基于深度学习和虚拟筛选的新型衔接蛋白相互作用蛋白激酶1抑制剂的发现及验证研究
Bo Liu,Likun Zhao,Yi Tan et al.
Bo Liu et al.
Receptor-interacting protein kinase 1 (RIPK1) serves as a critical mediator of cell necroptosis and represents a promising therapeutic target for various human neurodegenerative diseases and inflammatory diseases. Nonetheless, the RIPK1 inh...
Exploration of the Therapeutic Potential of the Epigenetic Modulator Decitabine on 6-OHDA-Induced Experimental Models of Parkinson's Disease [0.03%]
DNA甲基转移酶抑制剂地西他滨对6-OHDA诱导的帕金森病模型小鼠的治疗作用及机制研究
Shobha Kumari,Rajesh Pradhan,Sunil Kumar Dubey et al.
Shobha Kumari et al.
Parkinson's disease (PD) poses a global menace, as the available treatment methods solely aim to mitigate symptoms. An effective strategy to address the pathogenesis of PD involves eliminating the accumulation of aggregated alpha-synuclein,...