Poliumoside Exhibits Neuroprotective Effects against Cerebral Ischemia-Reperfusion Injury by Relieving Microglia-Mediated Neuronal Damage and Astrocytic Activation [0.03%]
多聚芸香苷通过缓解微胶质细胞介导的神经元损伤和星形胶质细胞活化对抗脑缺血再灌注损伤的神经保护作用
Liping Bai,Zhiming Guan,Jianwen Zhang et al.
Liping Bai et al.
Excessive activation of microglia contributes to neuronal damage and astrocytic activation during cerebral ischemia and hypoxia. Poliumoside (Pol) is a caffeoylated phenylpropanoid glycoside with significant anti-inflammatory and antioxidan...
Visualization of Apolipoprotein E-Binding Amyloid Plaques in Postmortem Alzheimer's Disease Brains Using a Novel Fluorescent Probe THK-5320 [0.03%]
用于阿尔茨海默病大脑中APOE结合淀粉样斑块成像的新型荧光探针THK-5320的可视化研究
Ryuichi Harada,Kaede Kudo,Gonzalo Carmona Soto et al.
Ryuichi Harada et al.
(E)-2-(4-(dimethylamino)styryl)-N,N-dimethylquinolin-6-amine) (THK-5320) is a unique fluorescent compound that recognizes apolipoprotein E (ApoE)-binding amyloid plaques in postmortem human brain sections. To understand the distinctive char...
Ruxolitinib Ameliorates Neuronal Pyroptosis in the Acute Phase of Intracerebral Hemorrhage through Inhibiting the Activation of Caspase-8 [0.03%]
鲁索利替尼通过抑制Caspase-8活化改善脑出血急性期神经元焦亡
Guang Chen,Mengbei Sun,Mingming Li et al.
Guang Chen et al.
Intracerebral hemorrhage (ICH) is a common type of stroke with higher rates of death and neurological dysfunction than ischemic stroke. Based on previous studies, we found that reducing neuronal pyroptosis in the acute phase of ICH improved...
Decoding Neuropeptide Complexity: Advancing Neurobiological Insights from Invertebrates to Vertebrates through Evolutionary Perspectives [0.03%]
从进化角度解析神经肽的复杂性：从无脊椎动物到脊椎动物的神经生物学新见解
Lauren Fields,Tina C Dang,Vu Ngoc Huong Tran et al.
Lauren Fields et al.
Neuropeptides are vital signaling molecules involved in neural communication, hormonal regulation, and stress response across diverse taxa. Despite their critical roles, neuropeptide research remains challenging due to their low abundance, ...
Delineating the Mechanistic Insight of Inhibition of α-Synuclein Fibrillation by Neuro Metabolite, Myo-inositol: Implications in Synucleopathies-Related Disorders [0.03%]
神经代谢物肌醇抑制α-突触核蛋白纤维化的机制见解及其在与突触核蛋白病相关疾病中的意义
Tanzeel Khan,Abdus Samad,Rashid Waseem et al.
Tanzeel Khan et al.
The fibrillation of α-synuclein (α-syn) is a major factor contributing to neuronal damage and is critical in developing synucleopathies-related disorders. Considering this, the discovery of new compounds that can inhibit or modulate α-sy...
Comprehensive Analysis of circRNA Expression and circRNA-miRNA-mRNA Networks in the Ventral Hippocampus of the Rat: Impact of Chronic Stress and Biological Sex [0.03%]
慢性压力和生物性别的影响：对慢性压力和生物性别下的大鼠腹侧海马区circRNA表达及circRNA-miRNA-mRNA网络的全面分析
Juan Pablo Silva,Wladimir A Corrales,Julia Catalán et al.
Juan Pablo Silva et al.
This study provides new insights into how sex and chronic stress influence circRNA expression in the rat ventral hippocampus, a region critical for emotional processing. We identified 206 sex-biased circRNAs and 194 stress-responsive circRN...
Exploring the Role of Psychedelics in Modulating Ego and Treating Neuropsychiatric Disorders [0.03%]
探究 psychedelics 在调节自我和治疗神经精神疾病中的作用
Hongshuang Wang,Xiaohui Wang
Hongshuang Wang
This viewpoint explores the therapeutic potential of psychedelics in treating neuropsychiatric disorders, particularly through the modulation of brain entropy and the experience of ego dissolution. Psychedelics disrupt rigid neural patterns...
Biofilm Biology to Brain Health: Harnessing Microbial Wisdom to Uncover Amyloid Dissociating Bifunctional Nano Chaperones for Alzheimer's Therapeutics [0.03%]
从生物被膜生物学至大脑健康：利用微生物智慧揭开阿尔茨海默病治疗中分解淀粉样蛋白的双功能纳米分子伴侣的秘密
Shiwani Randhawa,Trilok Chand Saini,Manik Bathla et al.
Shiwani Randhawa et al.
Microbial infections have long been implicated in the gut-brain link to Alzheimer's disease (AD). These infections may influence AD development either directly, through brain invasion, or indirectly via bacterial metabolites crossing the bl...
Voltage Sensitivity of Indocyanine Green in Polarized Membranes: A Computational Study [0.03%]
(ICG)在极化膜中的电压敏感性：一种计算方法研究
Micaela J Sosa,Andres I Bertoni,Cristián G Sánchez et al.
Micaela J Sosa et al.
Indocyanine green (ICG) is an amphiphilic, near-infrared, FDA-approved fluorescent dye with established voltage sensitivity in biomembranes, making it a promising candidate for voltage sensing and imaging, particularly in neurons where acti...
Tau Repeats Disassemble Amyloid-β Fibrils In Vitro by Interacting with KLVFFA and GGVVIA Domains [0.03%]
tau通过与KLVFFA和GGVVIA结构域相互作用而使淀粉样蛋白-β原纤维解组装
Soljee Yoon,Anouschka T Deidesheimer,Wonbin Seo et al.
Soljee Yoon et al.
The interplay between amyloid beta (Aβ) and tau protein is acknowledged as a crucial factor in the progression of Alzheimer's disease (AD), yet the precise molecular mechanisms underlying their interaction remain elusive. In this study, we...