Nicole D Bartolo,Sarah E Reid,Hema S Krishnan et al.
Nicole D Bartolo et al.
Voltage-gated sodium channels (Navs) play a crucial electrical signaling role in neurons. Nav-isoforms present in peripheral sensory neurons and dorsal root ganglia of the spinal cord are critically involved in pain perception and transmiss...
Amide Proton Transfer-Weighted Imaging Detects Hippocampal Proteostasis Disturbance Induced by Sleep Deprivation at 7.0 T MRI [0.03%]
胺质子转移加权成像在7.0 T MRI下检测到睡眠剥夺引起的海马蛋白稳态干扰
Zhihong Zhao,Xiaojun Zhang,Xiaolei Zhang et al.
Zhihong Zhao et al.
Sleep deprivation leads to hippocampal injury. Proteostasis disturbance is an important mechanism linking sleep deprivation and hippocampal injury. However, identifying noninvasive imaging biomarkers for hippocampal proteostasis disturbance...
Observation of α-Synuclein Preformed Fibrils Interacting with SH-SY5Y Neuroblastoma Cell Membranes Using Scanning Ion Conductance Microscopy [0.03%]
扫描离子电导显微镜观察预成纤维α-突触核蛋白与SH-SY5Y神经母细胞瘤细胞膜的相互作用
Christina Feng,Marisol Flores,Christina Dhoj et al.
Christina Feng et al.
Parkinson's disease (PD) is the second-most prevalent neurodegenerative disorder in the U.S. α-Synuclein (α-Syn) preformed fibrils (PFFs) have been shown to propagate PD pathology in neuronal populations. However, little work has directly...
MiR-191-5p Attenuates Tau Phosphorylation, Aβ Generation, and Neuronal Cell Death by Regulating Death-Associated Protein Kinase 1 [0.03%]
miR-191-5p通过调节死亡相关蛋白激酶1减弱Tau磷酸化，Aβ生成和神经元细胞死亡
Long Wang,Xindong Shui,Mi Zhang et al.
Long Wang et al.
Dysregulation of microRNAs has been implicated in diverse diseases, including Alzheimer's disease (AD). MiR-191-5p in plasma/serum has been identified as a novel and promising noninvasive diagnostic biomarker for AD. However, whether miR-19...
Characterization of a Potential KOR/DOR Dual Agonist with No Apparent Abuse Liability via a Complementary Structure-Activity Relationship Study on Nalfurafine Analogues [0.03%]
通过研究恩那夫兰フィン类似物的互补性结构活性关系来表征潜在的KOR / DOR双重激动剂并无明显滥用的可能性
Mengchu Li,David L Stevens,Michelle Arriaga et al.
Mengchu Li et al.
Discovery of analgesics void of abuse liability is critical to battle the opioid crisis in the United States. Among many strategies to achieve this goal, targeting more than one opioid receptor seems promising to minimize this unwanted side...
Immobilized Amyloid Hexamer Fragments to Map Active Sites of Amyloid-Targeting Chemicals [0.03%]
用于绘制靶向淀粉样蛋白化学物质的活性位点的固定化淀粉样蛋白六聚体片段
Illhwan Cho,Soljee Yoon,Sunghyun Park et al.
Illhwan Cho et al.
As amyloid-β (Aβ) peptide is considered a biomarker and pathological culprit of Alzheimer's disease, Aβ-targeting compounds have been investigated for diagnostics development and drug discovery of the disorder. Unlike amyloid plaque targ...
Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease [0.03%]
具有双Aβ/Tau抑制活性物质的发现及其对阿尔茨海默症果蝇模型治疗效果的评价
Annachiara Gandini,Ana Elisa Gonçalves,Silvia Strocchi et al.
Annachiara Gandini et al.
Alzheimer's disease (AD), the most common type of dementia, currently represents an extremely challenging and unmet medical need worldwide. Amyloid-β (Aβ) and Tau proteins are prototypical AD hallmarks, as well as validated drug targets. ...
Aluminum Oxide Nanoparticles Impair Working Memory and Neuronal Activity through the GSK3β/BDNF Signaling Pathway of Prefrontal Cortex in Rats [0.03%]
氧化铝纳米颗粒通过大鼠前额皮质的GSK3β/BDNF信号通路损害工作记忆和神经元活动
Wei Sun,Zhenzhong Lu,Xiao Chen et al.
Wei Sun et al.
Studies demonstrated that alumina nanoparticles (alumina NPs) impair spatial cognition and hippocampus-dependent synaptic plasticity. Although alumina NPs accumulate in the prefrontal cortex (PFC), their effects on PFC-mediated neuronal and...
GABAergic Neuromuscular Junction Suppresses Intestinal Defense of Caenorhabditis elegans by Attenuating Muscular Oxidative Phosphorylation [0.03%]
γ-氨基丁酸能神经肌肉接头通过减弱肌肉氧化磷酸化来抑制秀丽隐杆线虫的肠道防御
Jiayu Wu,Shengmei Yang,Junqiang Liu et al.
Jiayu Wu et al.
Innate immunity is an ancient and evolutionarily conserved system that constitutes the first line of host defense against invading microbes. We previously determined that the GABAergic neuromuscular junction (NMJ) suppresses intestinal inna...
PET Imaging of P2X7 Receptor (P2X7R) for Neuroinflammation with Improved Radiosynthesis of Tracer [18F]4A in Mice and Non-human Primates [0.03%]
使用改进示踪剂[18F]4A的放射合成对小鼠和非人灵长类动物神经炎症的P2X7受体(P2X7R)进行PET成像研究
Guolong Huang,Yifan Qiu,Lei Bi et al.
Guolong Huang et al.
The P2X7 receptor (P2X7R) is a key neuroinflammation target in a variety of neurodegenerative diseases. Improved radiosynthesis was developed according to the previously reported P2X7R antagonist GSK1482160. Biodistribution, radiometabolite...