Aberrant Reduction of Short-Chain Fatty Acid (SCFA) Receptor GPR41 and Transporter MCT4 in Prion-Infected Rodent and Cell Models [0.03%]
异链球菌感染的啮齿动物和细胞模型中短链脂肪酸受体GPR41和转运蛋白MCT4异常减少
Yuan Wang,Ruhan A,Xiaoxi Jia et al.
Yuan Wang et al.
Mounting evidence shows that short-chain fatty acids (SCFAs), derived mainly from intestinal bacteria, play a significant role in maintaining the homeostasis of the immune system and the central nervous system (CNS). SCFAs, directly or indi...
Molecular Perspective of Dietary Influences on the Gut Microbiome alongside Neurological Health: Exploring the Gut-Brain Axis [0.03%]
饮食对肠道微生物群及其神经系统健康影响的分子研究：探讨肠-脑轴联系
Zahra H Almahal,Anwarul Hasan,Shaikh Abdur Razzak et al.
Zahra H Almahal et al.
Gut-brain axis, an intricate, two-way communication network between gut microorganisms and the central nervous system, plays a critical role in controlling brain function and thereby influencing mental health. Changes to this axis, frequent...
Deciphering the Inhibitory Mechanism of ALS-Associated N352S and S352p Variants against TDP-43 Aggregation and Its Destabilization Effect on TDP-43 Protofibrils [0.03%]
阿尔茨海默病相关N352S和S352p突变体抑制TDP-43聚集的作用机理及对TDP-43原纤维的去稳定作用解析
Zhengdong Xu,Wenjuan Yi,Lulu Guan et al.
Zhengdong Xu et al.
Amyotrophic lateral sclerosis (ALS) is closely related to ubiquitin-positive inclusions formed by transactive response deoxyribonucleic acid (DNA) binding protein of 43 kDa (TDP-43). Previous experiments identified that the ALS-linked famil...
Monomers, Dimers, and Oligomers of Pyroglutamate-Modified α-Synuclein Fragments Exhibit Distinct Biophysical Characteristics [0.03%]
吡咯烷残基修饰的α-突触核蛋白片段单体、二聚体和寡聚体具有不同的生物物理特性
Alexandra Bluhm,Wei Xiang,Frank Wien et al.
Alexandra Bluhm et al.
α-Synuclein (aSyn) aggregation represents a key event in the neurodegenerative cascade of synucleinopathies. Initially, aSyn appears as an intrinsically disordered protein. However, its structural flexibility allows aSyn to either adopt α...
The Role of α-Synuclein-DNAJB6b Coaggregation in Amyloid Suppression [0.03%]
α-突触核蛋白-DNJB6b共聚集在淀粉样蛋白抑制中的作用
Tinna Pálmadóttir,Josef Getachew,Dev Thacker et al.
Tinna Pálmadóttir et al.
Chaperones may retard the aggregation of other proteins and increase their solubility. An important goal is a thermodynamic understanding of such an action. Here, the chaperone DNAJB6b (JB6) is found to suppress amyloid formation of the pro...
Zinc-Dependent Modulation of Dopamine Release and Uptake Is Altered in Parkinson's Disease Model Zebrafish [0.03%]
锌依赖性多巴胺释放和摄取的调节在帕金森病模型斑马鱼中发生改变
Piyanka Hettiarachchi,Austin Shigemoto,Erin E Hickey et al.
Piyanka Hettiarachchi et al.
Parkinson's disease (PD) is a neurodegenerative movement disorder in which dopaminergic neurons progressively degenerate, resulting in impaired dopamine system function. The release and uptake of dopamine (DA) are modulated, in part, by fre...
Enantiospecific Positive Allosteric Modulation of α4β2 Nicotinic Receptor Subtypes [0.03%]
α4β2型烟碱乙酰胆碱受体构象激活的对映选择性正向变构调节
Josue Gaona,Pradip K Gadekar,Khaldoun S Abdelwahed et al.
Josue Gaona et al.
Nicotinic acetylcholine receptors (nAChRs) are integral to brain function, playing critical roles in cognition and reward pathways. Among these, α4β2 nAChRs are key targets for developing therapeutics to address nicotine addiction and cog...
The Orphan Receptor GPR151: Discovery, Expression, and Emerging Biological Significance [0.03%]
孤儿受体GPR151：发现、表达及潜在生物学意义
Olivia DePasquale,Chris O&#x;Brien,Baila Gordon et al.
Olivia DePasquale et al.
G protein-coupled receptors (GPCRs) are among the most prominent druggable targets in the human genome, accounting for approximately 40% of marketed drugs. Despite this, current GPCR-targeted therapies address only about 10% of the GPCRs en...
Poliumoside Exhibits Neuroprotective Effects against Cerebral Ischemia-Reperfusion Injury by Relieving Microglia-Mediated Neuronal Damage and Astrocytic Activation [0.03%]
多聚芸香苷通过缓解微胶质细胞介导的神经元损伤和星形胶质细胞活化对抗脑缺血再灌注损伤的神经保护作用
Liping Bai,Zhiming Guan,Jianwen Zhang et al.
Liping Bai et al.
Excessive activation of microglia contributes to neuronal damage and astrocytic activation during cerebral ischemia and hypoxia. Poliumoside (Pol) is a caffeoylated phenylpropanoid glycoside with significant anti-inflammatory and antioxidan...
Visualization of Apolipoprotein E-Binding Amyloid Plaques in Postmortem Alzheimer's Disease Brains Using a Novel Fluorescent Probe THK-5320 [0.03%]
用于阿尔茨海默病大脑中APOE结合淀粉样斑块成像的新型荧光探针THK-5320的可视化研究
Ryuichi Harada,Kaede Kudo,Gonzalo Carmona Soto et al.
Ryuichi Harada et al.
(E)-2-(4-(dimethylamino)styryl)-N,N-dimethylquinolin-6-amine) (THK-5320) is a unique fluorescent compound that recognizes apolipoprotein E (ApoE)-binding amyloid plaques in postmortem human brain sections. To understand the distinctive char...