Nomilin Alleviates Neuroinflammation and Depressive-like Behaviors in Mice through the Upregulation of TAX1BP1-Mediated Modulation of Microglia Polarization [0.03%]
nomilin通过上调TAX1BP1介导的微胶质细胞极化调控缓解小鼠神经炎症和抑郁样行为
Jiaqi Li,Zhiping Yang,Jie Zhao et al.
Jiaqi Li et al.
Nomilin is a limonoid compound that is found in citrus fruits. However, their functions remain to be further studied. The present study mainly analyzed the antineuroinflammation and antidepressive function of nomilin. The antidepressant and...
Knockdown SIRT6 Alleviates Blood-Brain Barrier Disruption after Subarachnoid Hemorrhage through Inhibiting Ferroptosis by Promoting SMARCA2 Acetylation [0.03%]
SIRT6敲低通过促进SMARCA2乙酰化抑制铁死亡从而缓解蛛网膜下腔出血后的血脑屏障破坏
Li Lv,Long Zhang,Yan Wang et al.
Li Lv et al.
Ferroptosis has been identified as a mechanism underlying subarachnoid hemorrhage (SAH), attributed to blood-brain barrier (BBB) disruption. This study aimed to explore whether SIRT6 mediates ferroptosis affecting BBB disruption after SAH a...
Predicting Δ-9-Tetrahydrocannabinol-Induced Psychoactive and Cognitive Effects: A PBPK-PD Approach to Quantifying Feeling High and Reduced Alertness [0.03%]
基于PBPK-PD方法预测Δ-9-四氢大麻酚致精神病理和认知效应：量化“兴奋”和“警觉下降”的程度
Lixuan Qian,Zhu Zhou
Lixuan Qian
The increasing use of cannabis for medicinal and recreational purposes highlights the need to understand its psychoactive effects. Δ-9-tetrahydrocannabinol (THC), the primary psychoactive cannabinoid, is responsible for feeling high and re...
Aryl Guanyl Hydrazones: A Viable Strategy for Designing BBB-Permeable, Neuroactive Compounds? [0.03%]
脑渗透和神经活性化合物的设计的新策略：苯基瓜烷胲腙类化合物
Eleonora Colombo,Leonardo Maiorana,Greta Donati et al.
Eleonora Colombo et al.
Guanyl hydrazones are emerging as valuable, target-tunable functional groups. In particular, aryl guanyl hydrazones, owing to extensive conjugation with aromatic rings, exhibit lower pKa values compared to their aliphatic counterparts, so t...
Investigating the Interactions of a Cyclic Peptide Hormone Somatostatin and Its Derivatives on Amyloid-Beta Aggregation [0.03%]
环肽激素生长抑素及其衍生物抑制淀粉样蛋白聚集的相互作用机制研究
Amy Trinh Pham,Yusheng Zhao,Amy Oo et al.
Amy Trinh Pham et al.
We investigated the effects of cyclic peptides somatostatin, its isomer d-Trp8-somatostatin, and marketed somatostatin derivatives octreotide and lanreotide on Aβ42 aggregation and cytotoxicity in mouse hippocampal HT22 cells. The aggregat...
Profiling the Impact of mGlu7/Elfn1 Protein Interactions on the Pharmacology of mGlu7 Allosteric Modulators [0.03%]
mGlu7/Elfn1蛋白相互作用对mGlusallosteric调节剂药理学的影响谱型分析
Xia Lei,Zixiu Xiang,Alice L Rodriguez et al.
Xia Lei et al.
The group III metabotropic glutamate receptors (mGlu receptors) are predominantly expressed presynaptically throughout the central nervous system (CNS) where they regulate the release of glutamate and GABA. These receptors have recently bee...
Tau Oligomers in Alzheimer's Disease: Modulation Effect of Osmolytes on Amplified Brain-Derived Tau Oligomers [0.03%]
阿尔茨海默病中的tau寡聚体：渗透调节剂对脑源性tau原纤维生长的调制作用
Sharif Arar,Md Anzarul Haque,Anas Kayed et al.
Sharif Arar et al.
Tau is bound to microtubules and plays a key role in their assembly and spatial organization. Under pathological conditions, tau detaches from the microtubules and develops a propensity to self-aggregate into soluble tau oligomers (TauO), p...
A Structure-Activity Relationship Study of Novel Positive Allosteric Modulators for the δ-Opioid Receptor [0.03%]
新型δ阿片受体阳性变构调节剂的构效关系研究
Owindeep Deo,Vi Pham,Sadia Alvi et al.
Owindeep Deo et al.
Chronic pain and depression are widely prevalent comorbid conditions with limited safe, yet effective treatments. While μ-opioid receptor (MOR) agonists are effective for treating pain, they are plagued with significant drawbacks, includin...
Exosomes and Their miRNA as a Potential Biomarker in the Diagnosis of Parkinson's Disease [0.03%]
外泌体及其miRNA作为诊断帕金森病的潜在生物标志物
Srilakshmi Vijayakumar,Beryl Vedha Yesudhason,Jenif Leo Anandharaj et al.
Srilakshmi Vijayakumar et al.
Exosomes are the smallest of the extracellular vesicles, essential in intercellular communication by transporting lipids, proteins, and RNA, thereby influencing the recipient cells. The exosomes from cerebrospinal fluid, central nervous sys...
Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned Media [0.03%]
一种新型双重作用机制的GRT-X激动剂通过作用于Kv7钾通道/转运蛋白受体来预防暴露于小鼠和人类肌萎缩侧索硬化症/额颞叶痴呆星形胶质细胞培养基后的运动神经元退变
Vera M Masegosa,Elsa Fritz,Daniela Corvalan et al.
Vera M Masegosa et al.
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) form a continuous spectrum of aggressive neurodegenerative diseases affecting primarily motoneurons (MNs) and cortical frontotemporal neurons. Noncell autonomous mechanis...