Understanding the Photodynamic Behavior of Red Emitting Re(I)dipyrrinates in Triple-Negative Breast Cancer Cells [0.03%]
探究红光发射的Re(I)双吡咯𬭩盐在三阴性乳腺癌细胞中的光动力学行为
Neha Manav,Jaydeepsinh Chavda,Dhiraj Bhatia et al.
Neha Manav et al.
The Re-(I)-dipyrrinates complexes having oligo ethylene glycol (OEG) and thioglucose/thiogalactose sugars at the C-8 position are explored for anticancer applications. The X-ray crystal structure of Re-(I)-dipyrrinate having a thiogalactose...
Novel 1H-Indole-3-carboxamide Derivatives as CDK4 Inhibitors for Treating Cancer [0.03%]
作为治疗癌症的CDK4抑制剂的新苯并吲哚-3-甲酰胺衍生物
Ram W Sabnis
Ram W Sabnis
Provided herein are novel 1H-indole-3-carboxamide derivatives as CDK4 inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, and processes for preparing such compounds. ...
Targeted Degradation of CDK2: A New Strategy for Overcoming Cyclin E‑Driven Cancers [0.03%]
靶向降解CDK2：克服由细胞周期蛋白E驱动的癌症的新策略
Anna C Renner,Robert B Kargbo
Anna C Renner
Cyclin-dependent kinase 2 (CDK2) has emerged as a critical oncogenic driver in cancers characterized by cyclin E amplification and resistance to existing cell-cycle therapies. A recent patent disclosure describes heterobifunctional degrader...
Synthetic Diastereomers of the Fungal Cycloheptapeptide Paraisariamide A Retain Ternatin-Like Biological Activity [0.03%]
帕瑞萨里胺A的合成非对映异构体保留类似ternatin的生物活性
Sophia E Bonar,Daphne R Mattos,Takumi Arai et al.
Sophia E Bonar et al.
Paraisariamides (Psds) are a family of fungal N-methylated cyclic heptapeptides with structural similarity to the translation eukaryotic elongation factor 1A inhibitor ternatin. Initial characterization of the eight known Psds A-H revealed ...
Ram W Sabnis
Ram W Sabnis
Provided herein are novel heterocyclic compounds, pharmaceutical compositions, use of such compounds for treating HIV infection, and processes for preparing such compounds. ...
Novel 6,5-Bicyclic Compounds as 5‑HT2A Receptor Agonists for Treating Depression, Anxiety, Substance Abuse, and Headaches [0.03%]
一类新型六元五元并环化合物及其在制备5-ht2a受体激动剂中的应用
Ram W Sabnis,Anika R Sabnis
Ram W Sabnis
Provided herein are novel 6,5-bicyclic compounds as 5-HT2A receptor agonists, pharmaceutical compositions, use of such compounds in treating depression, anxiety, substance abuse, and headaches, and processes for preparing such compounds. ...
Nicotinamide-Based Covalent Inhibitors of tRNA (m1G37) Methyltransferase (TrmD) to Increase Antibacterial Activity [0.03%]
基于烟酰胺的tRNA(m₁G₃₇)甲基转移酶（TrmD）共价抑制剂，增强抗菌活性
Isao Masuda,Simon D P Baugh,Kevin McClay et al.
Isao Masuda et al.
Bacterial tRNA (m1G37) methyltransferase (TrmD) is an essential enzyme required for accurate translation and represents an attractive antibacterial target distinct from its eukaryotic counterpart, Trm5. Here, we describe the development of ...
Advancing Next-Generation Psychedelic Therapeutics through Selective 5‑HT2A Activation, Precision Aerosol Delivery, and Optimized 5‑MeO-DMT Treatment Paradigms [0.03%]
通过选择性5-HT2A激活、精准气溶胶输送和优化的5-MeO-DMT治疗方案推动下一代迷幻疗法的发展
Anna C Renner,Robert B Kargbo
Anna C Renner
The psychedelic therapeutics field continues to evolve beyond classical hallucinogens toward integrated treatment platforms that combine optimized pharmacology, drug delivery, and clinical implementation. Recent patent applications disclose...
Development of 2‑Methyl-5-phenylpyrrolidine-Based ST2 Inhibitors for Neuroinflammatory Conditions [0.03%]
基于2-甲基-5-苯基吡咯烷的ST2抑制剂在神经炎症条件下的开发
Xinrui Yuan,Eun Bee Cho,Amol D Patil et al.
Xinrui Yuan et al.
The cytokine receptor, ST2, is expressed in immune cells including type 2 T cells, microglia, and astrocytes. ST2 binds with IL-33 to activate the downstream NF-κB pathway. Besides the role of the ST2/IL-33 axis in the expansion of type 2 ...
Novel Benzofuran Derivatives as SARM1 Inhibitors for Treating Axonal Degeneration [0.03%]
新型苯并呋喃衍生物作为SARM1抑制剂用于治疗轴突变性
Ram W Sabnis,Anika R Sabnis
Ram W Sabnis
Provided herein are novel benzofuran derivatives as SARM1 inhibitors, pharmaceutical compositions, use of such compounds in treating axonal degeneration, and processes for preparing such compounds. ...