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期刊名:Acs medicinal chemistry letters

缩写:ACS MED CHEM LETT

ISSN:1948-5875

e-ISSN:N/A

IF/分区:4.0/Q2

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共收录本刊相关文章索引4577
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Cindy Meyer,Mayako Michino,David J Huggins et al. Cindy Meyer et al.
In early 2020, SARS-CoV-2 spread into a worldwide pandemic, causing more than 7 million deaths. Direct-acting antivirals (DAAs) complementing vaccines and mitigating severe disease in at-risk populations remain important. Here, we used a st...
Houda Tantawi,Philippe Mochirian,Mathieu Truong et al. Houda Tantawi et al.
A novel nucleoside analogue, LCB-2151, has been developed to induce cell death in KRAS-mutated pancreatic human cancer cell lines, which exhibit partial resistance to gemcitabine, a widely used anticancer drug. LCB-2151 disrupts the two pri...
Robert B Kargbo Robert B Kargbo
Recent advances targeting WRN helicase highlight a promising synthetic lethality approach for treating microsatellite instability-high (MSI-H) cancers. GlaxoSmithKline and Moma Therapeutics independently developed small molecule inhibitors ...
Xue Song,Chen-Guo Feng,Chen Wang et al. Xue Song et al.
The Toll-like receptor (TLR) family are critical components of the innate immune system, acting as pattern recognition receptors that detect microbial components and initiate immune responses. In humans, 10 TLRs have been identified, each r...
Ram W Sabnis Ram W Sabnis
Provided herein are novel compounds as 5-HT2A agonists, pharmaceutical compositions, use of such compounds in treating depression, and processes for preparing such compounds. ...
Yuanyuan Zhou,Ji Tao,Yuanpeng Jiang et al. Yuanyuan Zhou et al.
The thyroid-stimulating hormone receptor (TSHR) plays a pivotal role in regulating thyroid growth, function, synthesis, and secretion of thyroid hormones, with its overexpression linked to various diseases, especially in tumors. A novel TSH...
Steven H Liang Steven H Liang
Fibroblast activation protein (FAP) has emerged as a highly promising molecular target for cancer theranostics, with current research prioritizing the optimization of FAP-targeted radiopharmaceutical pharmacokinetics. The development of div...
Zhiwei Xiao,Jiyun Sun,Masayuki Fujinaga et al. Zhiwei Xiao et al.
Dysfunction of cyclic nucleotide phosphodiesterase 7 (PDE7) has been associated with excess intracellular cAMP concentrations, fueling pathogenic processes that are implicated in neurodegenerative disorders. This study aimed to develop a su...
Ram W Sabnis Ram W Sabnis
Provided herein are novel tricyclic compounds as ERK5 inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, and processes for preparing such compounds. ...
Ram W Sabnis Ram W Sabnis
Provided herein are novel fused heterocycles as 5-HT2A receptor agonists, pharmaceutical compositions, use of such compounds in treating neurological diseases, namely depression, anxiety, substance abuse and headaches, and processes for pre...