Combined detection of P53, Ki67, P504S, and IMP3: Diagnostic implications for gastric cancer and precursor lesions [0.03%]
P53、Ki67、P504S和IMP3联合检测在胃癌及其前驱病变诊断中的意义
Lan-Fang Miao,Yuan-Yuan Sun,Xian-Juan Du et al.
Lan-Fang Miao et al.
Background: Differential diagnosis among atypical hyperplasia (AH) (including reparative hyperplasia and intestinal metaplasia), low-grade dysplasia (LGD), high-grade dysplasia (HGD), and adenocarcinoma (AC) in gastric mu...
Simvastatin inhibits proliferation and migration, promotes oxidative stress and ferroptosis in colon cancer [0.03%]
辛伐他汀抑制结肠癌细胞增殖和迁移，促进氧化应激及铁死亡发生
Ying Liu,Hao Ge,Zhi-Min Fan et al.
Ying Liu et al.
Background: Colorectal cancer (CRC) is a major cause of cancer-related mortality, with limited therapeutic options for advanced stages. Simvastatin, primarily used to lower cholesterol, has shown potential as an anticance...
Switching from messenger RNAs to noncoding RNAs, METTL3 is a novel colorectal cancer diagnosis and treatment target [0.03%]
METTL3的职能从信使RNA到非编码RNA的转变及其作为结直肠癌诊断和治疗靶标的潜力
Jun-Nan Liao,Wen-Juan Ni,Ping-Hui Wu et al.
Jun-Nan Liao et al.
N6-methyladenosine (m6A) modification, one of the most prevalent RNA epigenetic modifications in eukaryotes, constitutes over 60% of all RNA methylation modifications. This dynamic modification regulates RNA processing, maturation, nucleocy...
Integrating ultrasound and serum indicators for evaluating outcomes of targeted immunotherapy in advanced liver cancer [0.03%]
超声和血清标志物在评估晚期肝癌靶向免疫治疗疗效中的应用研究
Hai-Bin Tu,Si-Yi Feng,Li-Hong Chen et al.
Hai-Bin Tu et al.
Background: Hepatocellular carcinoma (HCC) is a major global contributor to cancer-related mortality, with advanced stages presenting substantial therapeutic challenges. Although targeted immunotherapy shows potential, ma...
Techniques, perioperative outcomes, prognosis, and survival associated with laparoscopic surgery for T3-T4a colon cancer [0.03%]
腹腔镜手术治疗T3-4a期结肠癌的术式、围术期结果、预后及生存分析
Sheng-Ni Zhang,Lu Lu,Cun-Guang Lou et al.
Sheng-Ni Zhang et al.
Background: The efficacy of laparoscopic surgery for the treatment of T3-T4a colon cancer remains a subject of debate in the medical community. Aim: ...
Nomogram-based prognostic stratification for resectable gastric signet-ring cell carcinoma and adenocarcinoma: A retrospective cohort study [0.03%]
针对可切除胃黏液细胞癌和腺癌的预后分层 nomogram：一项回顾性队列研究
Hai-Tao Hu,Peng Wang,Yu-Juan Jiang et al.
Hai-Tao Hu et al.
Background: Gastric signet-ring cell carcinoma (GSRCC) is a more aggressive subtype of gastric cancer compared to gastric adenocarcinoma (GA), with an increasing incidence. However, the prognostic differences between thes...
Optimizing fluoropyrimidine therapy through dihydropyrimidine dehydrogenase polymorphism testing [0.03%]
通过二氢嘧啶脱氢酶多态性检测优化氟尿嘧啶类药物治疗
Arunkumar Krishnan
Arunkumar Krishnan
Fluoropyrimidines (FP), including 5-fluorouracil and its prodrug capecitabine, are commonly employed in treating various solid tumors. Nonetheless, their use is frequently constrained by severe toxicities in 20%-30% of patients. Pharmacogen...
Circulating exosomal miR-17-92 cluster serves as a novel noninvasive diagnostic marker for patients with gastric cancer [0.03%]
循环中的外泌体miR-17-92簇作为胃癌患者新的非侵入性诊断标志物
Ye Han,Xing-Po Guo,Qiao-Ming Zhi et al.
Ye Han et al.
Background: Gastric cancer (GC) is among the most common malignant tumors and remains a leading cause of cancer-related mortality worldwide. Furthermore, exosomal miRNAs are regarded as promising noninvasive biomarkers fo...
Imaging findings of primary monomorphic epitheliotropic intestinal T-cell lymphoma: A case report [0.03%]
原发性肠黏膜浸润型T细胞淋巴瘤的影像学表现：1例报告
Wen-Jian Tang,Shu-Hua Luo,Zhen Wu et al.
Wen-Jian Tang et al.
Background: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is an uncommon and highly aggressive form of lymphoma that represents less than 1% of all non-Hodgkin's lymphomas. At present, few reports have fo...
Diagnostic value of alpha-fetoprotein and prothrombin induced by vitamin K absence-II in serum, bile, and feces in hepatocellular carcinoma [0.03%]
甲胎蛋白和维生素K缺乏或拮抗-II型诱导的蛋白质在血清、胆汁和粪便中的诊断价值：肝细胞癌病例报告
Zi-Jun Chen,Xiang-Kun Wang,Chuang-Ye Han et al.
Zi-Jun Chen et al.
Background: Hepatocellular carcinoma (HCC) is the most common pathological type of liver cancer and was the third leading cause of cancer-related deaths worldwide in 2020. ...