Clinical value of geriatric nutritional risk index and pan-immune-inflammation value in locally advanced gastric cancer receiving neoadjuvant chemotherapy [0.03%]
老年营养风险指数和泛免疫炎症指标在局部晚期胃癌新辅助化疗中的临床价值评估
Wen-Tao Zhong,Shi-Kang Ding,Ru-Yin Li et al.
Wen-Tao Zhong et al.
Background: Metabolism and nutrition status play an important role in the development of cancer. However, whether inflammation and malnutrition related indicators can predict the efficacy of neoadjuvant chemotherapy (NACT...
Rui-Rui Yang,Ya-Ru Yan,Yu-Feng Li
Rui-Rui Yang
Gastric cancer remains a leading cause of global cancer mortality, with limited advances in its prevention and treatment owing to an incomplete understanding of its pathogenesis. Among the key precancerous lesions, spasmolytic polypeptide-e...
Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancer [0.03%]
胃癌中早老素1、β-catenin和p-PTEN表达量增加及其调控侵袭的作用机制
Xi Lin,Guo-Feng Lin,Fei-Teng Gu et al.
Xi Lin et al.
Background: Presenilin-1 (PS-1), a part of the gamma-secretase complex, has been implicated as a tumor promoter in various cancers. PS-1 binds to β-catenin through a large hydrophilic loop region that could lead to gastr...
Advancing precision medicine in human epidermal growth factor receptor 2 negative gastric cancer: Insights from a novel nomogram for immunochemotherapy prognosis [0.03%]
HER2阴性胃癌精准医疗新进展：基于免疫化疗预后列线图的启示
Abinash Nayak,Gunanidhi Sahoo,Sudhansu Sekhar Nishank
Abinash Nayak
Gastric cancer poses a significant global health burden, particularly in advanced human epidermal growth factor receptor 2-negative cases where prognosis remains poor despite advances in immunochemotherapy. The recent study by Yao et al int...
Impact of liver metastasis on the efficacy of immune checkpoint inhibitors for advanced colorectal cancer [0.03%]
肝转移对晚期结直肠癌免疫检查点抑制剂疗效的影响
Meng-Yue Xiang,Ze-Min Tuo,Xing-Kang Sa et al.
Meng-Yue Xiang et al.
Background: Liver metastasis is common in advanced colorectal cancer (CRC) and may influence the response to immune checkpoint inhibitors (ICIs). However, the prognostic impact of liver metastasis on ICI efficacy remains ...
Computed tomography with carcinoembryonic antigen and carbohydrate antigen 19-9 in diagnosing lymph node metastasis of early gastric cancer [0.03%]
癌胚抗原和糖类抗原计算机断层扫描诊断早期胃癌淋巴结转移病灶的价值
Hong-Zhi Chen,Ping Zhang,Jun Ma
Hong-Zhi Chen
Background: Gastric cancer (GC) is the fifth most prevalent and fourth most lethal malignancy globally. China bears a disproportionately high burden, accounting for 44.0% of new cases and 48.6% of deaths worldwide. In ear...
Pioneering efficient deep learning architectures for enhanced hepatocellular carcinoma prediction and clinical translation [0.03%]
开创性高效深度学习架构在肝细胞癌预测及临床转化中的应用研究
Sami Akbulut,Cemil Colak
Sami Akbulut
Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide and is often diagnosed at advanced stages, reducing opportunities for curative treatment. Current screening tools, includin...
Application value of multiphase contrast-enhanced computed tomography radiomics in preoperative evaluation of peritoneal metastasis in gastric cancer [0.03%]
多期增强CT影像组学在胃癌腹膜转移术前评估中的应用价值
Xiao-Dan Mu,Dong-Xu Ji,De-Qiang Kang
Xiao-Dan Mu
Background: Peritoneal metastasis occurs in 10%-45% of gastric cancer patients and significantly impacts prognosis and treatment decisions. Traditional computed tomography (CT) imaging has limited sensitivity (60%-80%) fo...
Total neoadjuvant therapy in rectal cancer: Challenging traditions without compromising surgical safety [0.03%]
直肠癌的全程新辅助治疗：挑战传统而不牺牲手术安全性
Riya Karmakar,Aditya Kandalkar,Arvind Mukundan
Riya Karmakar
Total neoadjuvant therapy (TNT) is swiftly transforming the therapeutic approach for locally advanced rectal cancer; yet, its integration as a standard practice necessitates meticulous evaluation of surgical safety, long-term outcomes, and ...
Wen-Mao Li,Yan Jiao,Si-Qi Liu et al.
Wen-Mao Li et al.
Esophageal squamous cell carcinoma (ESCC) remains one of the most lethal malignancies worldwide, with pronounced geographic and ethnic disparities in incidence and outcomes. Rapid advances in genome-wide and sequencing technologies have rev...