Impact of clinically significant portal hypertension on posthepatectomy liver failure: A systematic review and meta-analysis [0.03%]
临床显著门静脉高压对肝切除术后肝脏失败影响的系统评价和meta分析
Ming-Hao Ruan,Fei-Yang Ye,Jin-Ni Ma et al.
Ming-Hao Ruan et al.
Background: The health challenges of partial hepatectomy in patients with clinically significant portal hypertension (CSPH) have been a subject of study for decades. No meta-analysis has systematically evaluated the relat...
Whole-exome sequencing illuminates unexplained pediatric cholestatic liver disease [0.03%]
全外显子组测序或可解释儿童胆汁淤积性肝病病因
Toshifumi Yodoshi
Toshifumi Yodoshi
Unexplained liver disease in infants and children remains a significant diagnostic challenge as the spectrum of noninfectious pediatric liver disease expands. Timely, accurate etiologic assignment remains central to optimal care and resourc...
Clinical spectrum and genotype-phenotype correlation of ABCB4 mutations in children: Insights from a North Indian cohort [0.03%]
ABCB4突变在儿童中的临床谱系及基因型表型相关性：来自印度北部队列的见解
Chennakeshava Thunga,Suvradeep Mitra,Alisha Babbar et al.
Chennakeshava Thunga et al.
Background: Progressive familial intrahepatic cholestasis type 3, caused by mutations in the ABCB4 gene, is a rare genetic disorder. Although severe phenotypes due to biallelic mutations are well described, emerging data ...
Enhanced surgical tolerance of schistosomiasis-induced fibrotic liver following treatment with Ziziphus plant extract [0.03%]
枣属植物提取物治疗大鼠肝纤维化的疗效及其改善外科耐受性的机制研究
Thamer H Alghamdi
Thamer H Alghamdi
Background: Ziziphus spina-christi leaf extract (ZSCLE) can be used to treat hepatic schistosomiasis. However, its role as an anti-inflammatory and anti-proliferative agent remains unexplored. ...
Remote telerehabilitation for frailty management in liver transplant candidates: A feasible yet underutilized strategy [0.03%]
远程照护进行肝移植供体虚弱管理：一种可行但未充分利用的策略
Xu Cui,Bing-Qian Yin,Liu Chen
Xu Cui
This letter reviews Loschi et al's study evaluating structured telerehabilitation for frail cirrhotic liver transplant candidates, which fills a critical pre-transplant care gap. The video-based program, using low-cost tools and asynchronou...
Blood markers vs transient elastography for liver stiffness and steatosis in metabolic dysfunction-associated steatotic liver disease [0.03%]
代谢性功能障碍相关肝脂肪变性疾病患者中血清标志物与瞬时弹性成像评估肝脏硬度及脂肪变性的比较研究
Amal Joseph,Sunil Mathew,Harikumar R Nair
Amal Joseph
Background: Liver biopsy, once the gold standard for evaluating liver fibrosis and steatosis, has been largely replaced in routine clinical practice by non-invasive tools like Fibroscan®, which evaluate liver stiffness m...
Transforming growth factor beta reduces proprotein convertase subtilisin/kexin type 9 in the supernatant of hepatic stellate cells [0.03%]
转化生长因子β减少肝星状细胞上清液中前蛋白转化酶枯草杆菌肽/kexin亚型9水平
Jan Bundschuh,Maximilian Neumann,Sebastian Zimny et al.
Jan Bundschuh et al.
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is abundantly expressed by hepatocytes and regulates the uptake of low-density lipoprotein by these parenchymal cells. Little research has been conducted o...
Phase III, multicenter, randomized, double-blind, placebo-controlled study of norursodeoxycholic acid in metabolic dysfunction-associated steatotic liver disease patients [0.03%]
用于代谢功能障碍相关脂肪性肝病患者的鹅去氧胆酸III期、多中心、随机、双盲、安慰剂对照研究
Veerendra Kumar Panuganti,Chandrasekhar Varma Alluri,Javeed Mohammad et al.
Veerendra Kumar Panuganti et al.
Background: The norursodeoxycholic acid (norUDCA), a side chain-shortened derivative of ursodeoxycholic acid, exhibits unique pharmacological properties that may benefit patients with metabolic dysfunction-associated stea...
Clinical and biological significance of the relationship between gut microbiota and liver disease [0.03%]
肠道微生物与肝脏疾病关系的临床和生物学意义
Stanislav N Kotlyarov
Stanislav N Kotlyarov
The gut microbiota is of growing interest to clinicians and researchers due to its elucidating extensive role in metabolic and immune mechanisms, not only in the gut but also in other organs. The liver shares a close bidirectional relations...
Targeting sirtuin 1/nuclear factor erythroid 2-related factor 2/tumor necrosis factor-α pathway to modulate hepatic ischemia reperfusion-induced injury [0.03%]
靶向沉默信息调节因子1/细胞转录因子激活蛋白-1/肿瘤坏死因子-α通路调节肝脏缺血再灌注损伤
Mina Thabet Kelleni,Walaa Yehia Abdelzaher,Marly Adly et al.
Mina Thabet Kelleni et al.
Background: Hepatic ischemia reperfusion (HIR) injury is a major complication affecting various major liver surgeries, including liver transplantation. Aprepitant (APRE), a neurokinin-1 receptor antagonist, is commonly us...