Adipokine profiles reflect metabolic dysfunction but not fibrosis in patients with primary biliary cholangitis [0.03%]
脂联素谱系可反映原发性胆汁性肝炎患者的代谢功能障碍但不能反映纤维化水平
Tomas Koky,Sylvia Drazilova,Slavomira Komarova et al.
Tomas Koky et al.
Background: Primary biliary cholangitis (PBC) is a rare, nonsuppurative cholestatic disease that affects the small intrahepatic bile ducts. If not adequately managed, it may progress to liver cirrhosis and hepatocellular ...
Development and prospective validation of a machine learning model to predict mortality in cirrhosis with esophageal variceal bleeding [0.03%]
肝硬化伴食管静脉曲张出血预测死亡率的机器学习模型及其前瞻性验证
Matheus Machado Rech,Leandro Luis Corso,Elisa Fioreze Dal Bó et al.
Matheus Machado Rech et al.
Background: Acute esophageal variceal bleeding (AEVB) is a critical complication in patients with cirrhosis, associated with high mortality despite advancements in management. Traditional prognostic scores often lack pred...
Diagnostic challenges of clinically significant portal hypertension in geriatric metabolic dysfunction-associated fatty liver disease: A case report [0.03%]
老年代谢紊乱相关脂肪性肝病临床显著门脉高压的诊断难题——一例报告
Femmy Nurul Akbar,Nikko Darnindro,Annisa Ayu Wardhani et al.
Femmy Nurul Akbar et al.
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) may progress to cirrhosis and lead to serious complications. Lipid accumulation, hepatocellular ballooning, and sinusoidal endothelial dysfunction i...
Yahya Al-Hammada,Sinan Sharba,Samer Al-Dury
Yahya Al-Hammada
Methotrexate (MTX) remains a cornerstone therapy for chronic inflammatory diseases (e.g., rheumatoid arthritis, psoriasis). However, long-standing concerns about MTX hepatotoxicity - especially liver fibrosis - have historically led to cons...
Predictive tool for evident histological liver injury in chronic hepatitis B patients: Development and validation [0.03%]
慢性乙型肝炎患者显性肝病理损伤的预测工具：开发与验证
Zhong-Shang Dai,Xin Cao,Yong-Fang Jiang et al.
Zhong-Shang Dai et al.
Background: Chronic hepatitis B (CHB) is a leading cause of liver-related mortality, progressing to fibrosis, cirrhosis, and hepatocellular carcinoma. Existing noninvasive tools (e.g., aspartate aminotransferase to platel...
Klebsiella pneumoniae as leading cause of pyogenic liver abscess: Three years study in Southern Vietnam [0.03%]
Klebsiella肺炎性肝脓肿的病原菌：越南南部三年研究结果
Tuong-Anh Mai-Phan,Khanh-Phat Thai,Kim-Long Le et al.
Tuong-Anh Mai-Phan et al.
Background: Pyogenic liver abscess (PLA) is increasingly recognized worldwide. In Asia, Klebsiella pneumoniae (K. pneumoniae) has emerged as the predominant pathogen, yet contemporary data from Vietnam remain limited. ...
Performance of three clinical scores for steatosis and steatohepatitis and their interaction with metabolic syndrome in obese individuals [0.03%]
三种临床评分在肥胖人群脂肪肝诊断及与代谢综合征相互作用中的效能研究
Giovani Schulte Farina,Bárbara Brambilla,Emanuelle Mendonça Pandolfo et al.
Giovani Schulte Farina et al.
Background: Non-invasive clinical scores are widely used to detect hepatic steatosis and steatohepatitis, but their accuracy in individuals with obesity is limited. Most of these tools were developed for non-obese populat...
Assessing the associations between immunosuppressant use and COVID-19 severity in patients with autoimmune hepatitis [0.03%]
自身免疫性肝炎患者中免疫抑制剂使用与新冠肺炎严重程度关联的评估研究
Krish Rai,Karla J Lindquist,John Kornak et al.
Krish Rai et al.
Background: Due to immunosuppression (IS) use, patients with autoimmune hepatitis (AIH) may be at high risk for poor coronavirus disease 2019 (COVID-19) outcomes. ...
Environmental considerations in hepatitis E virus transmission: Is there a missing link? [0.03%]
乙型肝炎病毒传播中的环境因素：是否存在缺失环节？
Ross Campbell,Cerys Russell,Jacques Izopet et al.
Ross Campbell et al.
Hepatitis E virus (HEV) is a zoonotic infection that varies according to genotype and geographical location. The full environmental and public health impact of hepatitis E remains uncertain. In this review, we aim to synthesise the evidence...
Jun Xu,Ying Qian,Jun-Min Wang et al.
Jun Xu et al.
In this article, we discuss the recently published study by Wang et al, which investigated the therapeutic potential of levodopa, a well-known drug used to treat Parkinson's disease, for the treatment of liver diseases. The study revealed t...