Unravelling the reversion mechanisms of activated hepatic stellate cell properties by extracellular vesicles from mesenchymal stem cells [0.03%]
解析间充质干细胞外泌体逆转活化肝星状细胞特性的机制
Md Ariful Islam,Jannatul Mawya,Umme Salma et al.
Md Ariful Islam et al.
Hepatic fibrosis is a pathological process characterized by an imbalance between the deposition and degradation of extracellular matrix components. This process is initiated by chronic liver injuries resulting from viral infections, alcohol...
Application of stem cell-derived exosomes in bone and joint diseases: Recent advances enabled by diverse carrier technologies [0.03%]
干细胞来源的外泌体在骨关节疾病中应用的研究进展及多种递送方式的技术赋能作用
Ya-Jun Fu,Jie Jian,Can Liu et al.
Ya-Jun Fu et al.
Bone and joint diseases, such as osteoarthritis, exhibit significant pathological complexity. Current treatment modalities possess notable limitations, driving the development of cell-free regenerative treatment strategies centered on stem ...
Thymoquinone inhibited the chondrogenic differentiation of tendon-derived stem cells caused by tendon injury [0.03%]
鼠源肌腱损伤诱导的干细胞向软骨分化及姜黄素和蛇床子素的调控作用研究
Yi-Jun Tu,Yun-Qi Liu,Yan-Yan Pan et al.
Yi-Jun Tu et al.
Background: The micro-injury of collagen fibers occurs as the tendon is stretched repeatedly between the strains of 4% and 8%, which results in the cumulative micro-damage in tendon. In prior studies, we have shown that m...
Exosomal delivery of GrpE-like 1 from synovial mesenchymal stem cells activates PINK1-mediated mitophagy for cartilage repair in osteoarthritis [0.03%]
滑膜间充质干细胞源外泌体携带GrpE-like 1蛋白激活PINK1介导的线粒体自噬促进骨关节炎软骨修复
Soumya Deep Phadikar,Ramya Lakshmi Rajendran,Sathish Muthu et al.
Soumya Deep Phadikar et al.
GrpE-like 1 (GRPEL1)-carrying exosomes derived from synovial mesenchymal stem cells (SMSC) prevent mitochondrial dysfunction associated with osteoarthritis (OA) by activating PINK1-mediated mitophagy, restoring chondrocyte function, and pre...
Targeting adipose remodeling: Synergistic mechanisms of drugs and adipose-derived stem cells in obese type 2 diabetes mellitus [0.03%]
靶向脂肪重塑：肥胖2型糖尿病药物与脂肪来源干细胞的协同机制研究
Cheng Luo,Xian-Mei Yu,Liang-Yan Hua et al.
Cheng Luo et al.
Type 2 diabetes mellitus, particularly when accompanied by obesity, has become a major global public health burden. Visceral adipose tissue accumulation contributes to insulin resistance, lipotoxicity, and chronic inflammation, thereby acce...
Insights into mitofusin-2 and endoplasmic reticulum stress regulation in adipose-derived mesenchymal stem cells senescence [0.03%]
线粒体融合蛋白2和内质网应激在脂肪来源间充质干细胞衰老中的作用机制研究
Fang Lin,Ke-Xin Ma,Xiao-Ting Liang
Fang Lin
This article comments on the study by Fang, which demonstrates that reduced nuclear factor erythroid-derived 2 (NRF2) activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells from hypertrophic ...
Mitochondrial regulation of stem cell osteogenic differentiation: A key driver for bone regeneration [0.03%]
线粒体调控干细胞成骨分化：骨组织再生的关键驱动因素
Jing-Shun Lu,Yun-Hong Zhao,Fei-Yan Mu et al.
Jing-Shun Lu et al.
Mesenchymal stem cells (MSCs) are multipotent stromal cells that serve as progenitors for connective tissue and have emerged as a crucial resource in the field of tissue engineering owing to their capacity to differentiate into multiple cel...
Post-translational modifications in the oral microenvironment: Stem cell regulation from periodontal regeneration to oral cancer therapy [0.03%]
口腔微环境中的蛋白质修饰及口腔再生医学和干细胞治疗中的作用机制研究
Wei Liu,Yuan-Yuan Yang,Zhuo-Jin Shi
Wei Liu
The oral microenvironment plays a pivotal role in determining stem cell fate, driving both regeneration and pathological transformation. Emerging evidence suggests that post-translational modifications (PTMs) play a role as dynamic molecula...
Role of human umbilical cord mesenchymal stem cells in diabetic kidney disease [0.03%]
人脐带间充质干细胞在糖尿病肾脏病中作用的研究进展
Yan Liu,Xiao-Qian Shan,Yu-Jiao Li et al.
Yan Liu et al.
One of the most prevalent long-term effects of diabetes is diabetic kidney disease (DKD), which is linked to problems with the metabolism of amino acids, fats, and carbohydrates. The fundamental pathogenic mechanisms of DKD cannot be adequa...
CD146-positive mesenchymal stromal cells: A promising subtype for enhanced acute respiratory distress syndrome therapy [0.03%]
CD146阳性间充质基质细胞：用于增强急性呼吸窘迫综合征治疗的亚型候选者
Bin Li,Rui-Xi Ming,Yu-Meng Liu et al.
Bin Li et al.
Acute respiratory distress syndrome (ARDS) remains without effective targeted reparative therapies and continues to carry a high mortality rate. Here, we comment on a recent study by Zhang et al, who identify a CD146+ subpopulation of mesen...