Distinct Responses of Estrogen Receptor α and β in Chondrocytes Under Excessive Mechanical Stress [0.03%]
过度机械应力下软骨细胞中雌激素受体α和β的不同反应机制研究
Saki Takesue,Naoto Hirose,Makoto Yanoshita et al.
Saki Takesue et al.
IntroductionOsteoarthritis (OA) is more common in women, suggesting a link to estrogen. Estrogen supports cartilage homeostasis and metabolism via two receptors: ERα and ERβ. Mechanical stress is the primary cause of OA and affects cellul...
Contralateral Knee Alignment Parameters Have Limited Influence on Coronal Alignment Progression Compared With Ipsilateral Parameters in Patients With Knee Osteoarthritis [0.03%]
膝骨关节炎患者膝内侧间室骨关节炎进展与外膝参数关系有限：一项回顾性研究
Kee Soo Kang,Byung Sun Choi,Hyuk-Soo Han et al.
Kee Soo Kang et al.
ObjectiveTo compare alignment parameters in bilateral lower extremities and evaluate the effect of contralateral limb on hip-knee-ankle angle (HKAA) longitudinally.MethodsNative bilateral lower extremities of 3,045 Korean patients with long...
Subchondral Knee Injections: A Comprehensive Systematic Review of Current Clinical Outcomes, Safety, and Arthroplasty Delay [0.03%]
膝关节软骨下关节腔注射的系统评价：目前临床疗效、安全性及延缓人工关节置换的效果
Yazan Abu Salem,Carlotta Franceschi,Pietro Conte et al.
Yazan Abu Salem et al.
IntroductionOsteoarthritis is considered a whole-joint disease involving subchondral bone. Intraosseous therapies such as calcium phosphate (CaP), platelet-rich plasma (PRP), and mesenchymal stem cells (MSCs) offer joint-preserving options ...
Synovial Fluid Proteomic Biomarkers in Knee Osteoarthritis: A Systematic Review and Gene Ontology Analysis [0.03%]
膝骨关节炎滑液蛋白质组生物标志物的系统评价和基因本体分析
Elvira Immacolata Parrotta,Giorgia Lucia Benedetto,Giovanni Cuda et al.
Elvira Immacolata Parrotta et al.
BackgroundOsteoarthritis (OA) of the knee is a degenerative disorder characterized by cartilage degradation, synovial inflammation, and structural remodeling. Synovial fluid (SF) biomarkers may improve diagnosis, staging, and patient strati...
Synovial Biomarker Modulation and Clinical Response to Umbilical Cord-Derived MSC Treatment in Knee Osteoarthritis: A Case Series Study [0.03%]
人脐带来源间充质干细胞治疗膝骨关节炎的滑膜生物标志物改变及临床疗效：病例系列研究
Urban Švajger,Matic Kolar,Borut Pompe et al.
Urban Švajger et al.
ObjectiveUmbilical cord-derived mesenchymal stromal cells (UC-MSCs) are a promising treatment for knee osteoarthritis (KOA). This study aimed to (1) characterize early synovial fluid biomarker changes after intra-articular UC-MSCs therapy i...
Automated Objective Scoring of Osteoarthritis Severity in Mouse Medial Tibial Cartilage Using Deep Learning [0.03%]
基于深度学习的自动化客观评分系统在小鼠胫骨关节软骨骨关节炎严重程度评估中的应用研究
Ka Hyon Park,Young-Gwon Kim,Gyuseok Lee et al.
Ka Hyon Park et al.
ObjectiveThis study developed and optimized a deep learning model to automate OARSI-based histologic scoring of mouse medial tibial cartilage.DesignSafranin-O-stained cartilage images were obtained from mice with OA induced by medial menisc...
The Effect of Curcumin Treatment on Healing in a Rat Distal Femoral Osteochondral Defect Model [0.03%]
姜黄素治疗对骨软骨缺损修复影响的实验研究
Emin Can Balcı,Ender Alagöz,Abdurrahman Acar et al.
Emin Can Balcı et al.
BackgroundArticular cartilage injuries often heal with fibrocartilage rather than native hyaline cartilage, resulting in inferior biomechanical properties and increased osteoarthritis risk. Curcumin has anti-inflammatory and antioxidant pro...
The Use of Intra-Articular Hydrogel in Knee Osteoarthritis: A Systematic Review [0.03%]
透明质酸钠关节腔注射治疗膝骨关节炎的系统评价
Ashton Kai Shun Tan,Vijay Vengkat Samynathan C,Muhammad Sulaiman Dh et al.
Ashton Kai Shun Tan et al.
BackgroundKnee osteoarthritis (KOA) is a prevalent cause of disability. Current intra-articular injections (hyaluronic acid [HA] and corticosteroids) fall short in maintaining long-term effects and repeated usage may result in deleterious e...
Serial Changes in Graft Diameter Following Anterior Cruciate Ligament Reconstruction Using Allograft [0.03%]
异体移植前交叉韧带重建术后的移植物径向变化规律研究
Jun-Sang You,Sung-Sahn Lee,Dae-Hee Lee
Jun-Sang You
BackgroundTo evaluate the serial changes in graft diameter during the 2 years following anterior cruciate ligament (ACL) reconstruction using serial magnetic resonance imaging (MRI).MethodsThis study involved 38 patients (38 knees) who unde...
Bone Marrow Aspirate Concentrate on Hyaluronic Acid Scaffold Combined With Intraarticular Platelet-Rich Plasma for Full-Thickness Knee Cartilage Lesions: Clinical and Biological Outcomes in 165 Patients [0.03%]
富血小板血浆联合透明质酸钠支架的骨髓抽吸浓缩物治疗膝关节全层软骨缺损：165例患者的临床及生物学结果分析
Martin Lind,Torsten Grønbech Nielsen,Bjørn Borsøe Christensen et al.
Martin Lind et al.
ObjectiveThis study aimed to evaluate the clinical and biological outcomes of a one-step regenerative treatment using bone marrow aspirate concentrate (BMAC) on a hyaluronic acid scaffold combined with intraarticular platelet-rich plasma (P...