Mdm2 in evolution [0.03%]
MDMX在进化中的作用
David P Lane,Chandra Verma
David P Lane
While the presence, in the invertebrates, of genes related in sequence and function to the vertebrate p53 family has been known since the discovery of the fly Drosophila melanogaster Dmp53 and the worm Caenorhabditis elegans cep-1 gene, the...
Danielle R Okoro,Melissa Rosso,Jill Bargonetti
Danielle R Okoro
Cancer cells often have high expression of Mdm2. However, in many cancers mdm2 is alternatively spliced, with more than 40 mRNA variants identified. Many of the alternative spliced mdm2 mRNAs have the potential to encode truncated Mdm2 isof...
Xiang Zhou,Jun-Ming Liao,Wen-Juan Liao et al.
Xiang Zhou et al.
The oncoprotein MDM2 is both the transcriptional target and the predominant antagonist of the tumor suppressor p53. MDM2 inhibits the functions of p53 via a negative feedback loop that can be circumvented by several ribosomal proteins in re...
Anand Ponnuswamy,Ted Hupp,Robin Fåhraeus
Anand Ponnuswamy
The function and regulation of MDM2 as a component of a p53-dependent negative feedback loop has formed a core paradigm in the p53 field. This concept, now 20 years old, has been solidified by fields of protein science, transgenic technolog...
Alexia N Melo,Christine M Eischen
Alexia N Melo
The contribution of Mdm2, and its recently identified family member Mdmx (Mdm4), to tumorigenesis has primarily focused on their negative regulation of the p53 tumor suppressor. Although Mdm2 and Mdmx clearly inhibit p53, which can lead to ...
The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53 [0.03%]
MDM2和MDMX磷酸化在应激信号传递到p53中的作用
Jiandong Chen
Jiandong Chen
The p53 tumor suppressor is highly responsive to different physiological stresses such as abnormal cell proliferation, nutrient deprivation, and DNA damage. Distinct signaling mechanisms have evolved to activate p53, which in turn modulate ...
Lynn Biderman,James L Manley,Carol Prives
Lynn Biderman
p53 is an important tumor suppressor, functioning as a transcriptional activator and repressor. Upon receiving signals from multiple stress related pathways, p53 regulates numerous activities such as cell cycle arrest, senescence, and cell ...
It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53 [0.03%]
花前月下三人间：p53泛素连接酶的多样性和复杂性
Ian M Love,Steven R Grossman
Ian M Love
The transcription factor p53 regulates numerous cellular processes to guard against tumorigenesis. Cell-cycle inhibition, apoptosis, and autophagy are all regulated by p53 in a cell- and context-specific manner, underscoring the need for p5...
Dual Roles of MDM2 in the Regulation of p53: Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity [0.03%]
MDM2调节p53的双重作用：MDM2通过泛素依赖和非泛素机制抑制p53活性
Dingding Shi,Wei Gu
Dingding Shi
MDM2 oncogenic protein is the principal cellular antagonist of the p53 tumor suppresser gene. p53 activity needs exquisite control to elicit appropriate responses to differential cellular stress conditions. p53 becomes stabilized and active...
Maurisa F Riley,Guillermina Lozano
Maurisa F Riley
Mdm2 is an essential regulator of the p53 tumor suppressor. Mdm2 is modified at transcriptional, post-transcriptional, and post-translational levels to control p53 activity in normal versus stressed cells. Importantly, errors in these regul...