LINC00958 Accelerates Cell Proliferation and Migration in Non-Small Cell Lung Cancer Through JNK/c-JUN Signaling [0.03%]
长链非编码RNA LINC00958通过JNK/c-JUN信号转导途径促进非小细胞肺癌的增殖和迁移
Zhigang Luo,Zhiyi Han,Feng Shou et al.
Zhigang Luo et al.
Non-small cell lung cancer (NSCLC) denotes the most common type of lung cancers with high mortality globally. Long non-coding RNAs (lncRNAs) with differential expression have been indicated to be participants in the pathogenesis and develop...
Fast-Seq: A Simple Method for Rapid and Inexpensive Validation of Packaged Single-Stranded Adeno-Associated Viral Genomes in Academic Settings [0.03%]
一种简单的方法：在学术界环境下快速而廉价地验证包装好的单链腺相关病毒基因组（Fast-Seq）
Lucy H Maynard,Olivia Smith,Nicolas P Tilmans et al.
Lucy H Maynard et al.
Adeno-associated viral (AAV) vectors have shown great promise in gene delivery as evidenced by recent FDA approvals. Despite efforts to optimize manufacturing for good manufacturing practice (GMP) productions, few academic laboratories have...
Fast-Seq: A Simple Method for Rapid and Inexpensive Validation of Packaged Single-Stranded Adeno-Associated Viral Genomes in Academic Settings [0.03%]
快速简便的学术界包装单链腺相关病毒基因组验证方法
Lucy H Maynard,Olivia Smith,Nicolas P Tilmans et al.
Lucy H Maynard et al.
Adeno-associated viral (AAV) vectors have shown great promise in gene delivery as evidenced by recent FDA approvals. Despite efforts to optimize manufacturing for good manufacturing practice (GMP) productions, few academic laboratories have...
Nanoparticle Tracking of Adenovirus by Light Scattering and Fluorescence Detection [0.03%]
利用散射光和荧光检测进行腺病毒纳米颗粒追踪
Manuela Gast,Harald Sobek,Boris Mizaikoff
Manuela Gast
The detailed characterization of biological nanoparticles is of paramount importance for various industrial sectors, as for production of viral therapeutics. More recently, technologies that allow real-time quantification with simultaneous ...
Lot-to-Lot Variation in Adeno-Associated Virus Serotype 9 (AAV9) Preparations [0.03%]
腺相关病毒9型（AAV9）制剂的批次间差异
Deirdre M O&#x;Connor,Corinne Lutomski,Martin F Jarrold et al.
Deirdre M O&#x;Connor et al.
Viral vectors are complex drugs that pose a particular challenge for manufacturing. Previous studies have shown that, unlike small-molecule drugs, vector preparations do not yield a collection of identical particles. Instead, a mixture of p...
Patrick Wilmott,Leszek Lisowski,Ian E Alexander et al.
Patrick Wilmott et al.
Ongoing development of recombinant vectors based on adeno-associated virus (rAAV) is providing an increasingly powerful and widely used toolkit for gene transfer and genome editing applications. While conceptually simple, the system harbors...
Effects of Inhibition of miR-155-5p in Neural Stem Cell Subarachnoid Transplant on Rats with Cerebral Infarction [0.03%]
抑制miR-155-5p在神经干细胞亚急性蛛网膜下腔移植治疗脑梗死中的作用研究
Dong Wang,Liang Wang,Lin Bai et al.
Dong Wang et al.
Cerebral infarction is a leading cause of death, which calls for effective prevention and treatment. Transplant of neural stem cells (NSCs) is a potential therapeutic treatment to cerebral infarction although its efficacy still needs to be ...
Effects of Inhibition of miR-155-5p in Neural Stem Cell Subarachnoid Transplant on Rats with Cerebral Infarction [0.03%]
抑制miR-155-5p在神经干细胞蛛网膜下腔移植治疗脑梗死中的作用研究
Dong Wang,Liang Wang,Lin Bai et al.
Dong Wang et al.
Cerebral infarction is a leading cause of death, which calls for effective prevention and treatment. Transplant of neural stem cells (NSCs) is a potential therapeutic treatment to cerebral infarction although its efficacy still needs to be ...
Development of Versatile and Flexible Sf9 Packaging Cell Line-Dependent OneBac System for Large-Scale Recombinant Adeno-Associated Virus Production [0.03%]
一种通用且灵活的大规模重组腺相关病毒生产的OneBac系统及其依赖的多功能Sf9包装细胞系的开发
Yang Wu,Ting Mei,Liangyu Jiang et al.
Yang Wu et al.
Recombinant adeno-associated viruses (rAAVs) are excellent vectors for gene delivery. However, current Sf9/Cap-Rep packaging cell line-dependent OneBac systems still lack versatility and flexibility for large-scale production of rAAVs. In t...
Toward a Scalable Purification Protocol of GaLV-TR-Pseudotyped Lentiviral Vectors [0.03%]
一种GaLV-TR-假病毒载体的大规模纯化方案
Driss Boudeffa,Bérangère Bertin,Antoine Biek et al.
Driss Boudeffa et al.
Lentiviral vectors (LV) that are used in research and development as well as in clinical trials are in majority vesicular stomatitis virus G glycoprotein (VSVg) pseudotyped. The predominance of this pseudotype choice for clinical gene thera...