Exocrine pancreas regeneration modifies original pancreas to alleviate diabetes in mouse models [0.03%]
外分泌胰腺再生可改善小鼠模型的糖尿病症状
Xiaoxing Kou,Jin Liu,Dandan Wang et al.
Xiaoxing Kou et al.
Diabetes is a major public health issue because of its widely epidemic nature and lack of cure. Here, we show that pancreas-derived mesenchymal stem cells (PMSCs) are capable of regenerating exocrine pancreas when implanted into the kidney ...
Triple-negative breast cancer metastasis involves complex epithelial-mesenchymal transition dynamics and requires vimentin [0.03%]
三阴性乳腺癌转移涉及复杂的上皮间质转化动力学并需要波形蛋白
Eloïse M Grasset,Matthew Dunworth,Gaurav Sharma et al.
Eloïse M Grasset et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype associated with early metastatic recurrence and worse patient outcomes. TNBC tumors express molecular markers of the epithelial-mesenchymal transition (EMT), but its requirement ...
Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy [0.03%]
腔内生成胶质母细胞瘤干细胞特异性CAR巨噬细胞以启动术后局部免疫治疗
Chen Chen,Weiqiang Jing,Yu Chen et al.
Chen Chen et al.
Glioblastoma multiforme (GBM) remains incurable despite aggressive implementation of multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a narrow margin around the initial resected lesion due to posts...
Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes [0.03%]
APOE和谷氨酸相关基因的表达梯度易感于网络Tau扩散
Victor Montal,Ibai Diez,Chan-Mi Kim et al.
Victor Montal et al.
A key hallmark of Alzheimer's disease (AD) pathology is the intracellular accumulation of tau protein in the form of neurofibrillary tangles across large-scale networks of the human brain cortex. Currently, it is still unclear how tau accum...
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies [0.03%]
靶向SARS-CoV-2 S2的疫苗可引发广谱中和抗体
Kevin W Ng,Nikhil Faulkner,Katja Finsterbusch et al.
Kevin W Ng et al.
Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged during the current coronavirus disease 2019 (COVID-19) pandemic. Although antibody cross-reactivity with the spike glycoproteins (S) of diverse co...
Association of a common genetic variant with Parkinson's disease is mediated by microglia [0.03%]
小胶质细胞介导帕金森病常见遗传变异的影响
Rebekah G Langston,Alexandra Beilina,Xylena Reed et al.
Rebekah G Langston et al.
Studies of multiple neurodegenerative disorders have identified many genetic variants that are associated with risk of disease throughout a lifetime. For example, Parkinson's disease (PD) risk is attributed in part to both coding mutations ...
Antibody-mediated prevention of vaginal HIV transmission is dictated by IgG subclass in humanized mice [0.03%]
人源化小鼠中抗体介导的阴道HIV传播预防受IgG亚类的影响
Jacqueline M Brady,Meredith Phelps,Scott W MacDonald et al.
Jacqueline M Brady et al.
HIV broadly neutralizing antibodies (bNAbs) are capable of both blocking viral entry and driving innate immune responses against HIV-infected cells through their Fc region. Vaccination or productive infection results in a polyclonal mixture...
Anna C Obenauf
Anna C Obenauf
Functional interrogation of cancer and immune cells during tumor evolution reveals cancer drivers and informs mechanism-based combination therapies.
Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice [0.03%]
肠道微生物组通过释放组胺诱导小鼠内脏高敏感性
Giada De Palma,Chiko Shimbori,David E Reed et al.
Giada De Palma et al.
The gut microbiota has been implicated in chronic pain disorders, including irritable bowel syndrome (IBS), yet specific pathophysiological mechanisms remain unclear. We showed that decreasing intake of fermentable carbohydrates improved ab...
SARS-CoV-2 mRNA vaccination elicits robust antibody responses in children [0.03%]
儿童中SARS-CoV-2 mRNA疫苗接种产生强烈的抗体反应
Yannic C Bartsch,Kerri J St Denis,Paulina Kaplonek et al.
Yannic C Bartsch et al.
Although children have been largely spared from coronavirus disease 2019 (COVID-19), the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) with increased transmissibility, combined with flu...