Stratifying the autistic phenotype using electrophysiological indices of social perception [0.03%]
利用社会感知的电生理指标对自闭症表型进行分类
Luke Mason,Carolin Moessnang,Christopher Chatham et al.
Luke Mason et al.
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by difficulties in social communication, but also great heterogeneity. To offer individualized medicine approaches, we need to better target interventions by str...
Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine [0.03%]
佐剂亚单位疫苗诱导针对SARS-CoV-2奥密克戎变异株的长期保护力
Prabhu S Arunachalam,Yupeng Feng,Usama Ashraf et al.
Prabhu S Arunachalam et al.
Despite the remarkable efficacy of COVID-19 vaccines, waning immunity and the emergence of SARS-CoV-2 variants such as Omicron represents a global health challenge. Here, we present data from a study in nonhuman primates demonstrating durab...
Michael A Cook,Gerard D Wright
Michael A Cook
Antibiotics have transformed modern medicine. They are essential for treating infectious diseases and enable vital therapies and procedures. However, despite this success, their continued use in the 21st century is imperiled by two orthogon...
LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes [0.03%]
LINE-1 RNA 引起异染色质丢失并可成为改善衰老大鼠模型表型的靶点
Francesco Della Valle,Pradeep Reddy,Mako Yamamoto et al.
Francesco Della Valle et al.
Constitutive heterochromatin is responsible for genome repression of DNA enriched in repetitive sequences, telomeres, and centromeres. During physiological and pathological premature aging, heterochromatin homeostasis is profoundly compromi...
Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice [0.03%]
小鼠新月体形成肾脏祖细胞分化为足细胞减轻了严重的肾小球肾炎
Maria Elena Melica,Giulia Antonelli,Roberto Semeraro et al.
Maria Elena Melica et al.
Crescentic glomerulonephritis is characterized by vascular necrosis and parietal epithelial cell hyperplasia in the space surrounding the glomerulus, resulting in the formation of crescents. Little is known about the molecular mechanisms dr...
Adenoviral-based vaccine promotes neoantigen-specific CD8+ T cell stemness and tumor rejection [0.03%]
腺病毒载体疫苗可促进肿瘤新生抗原特异性CD8+T细胞记忆干细胞的形成并增强抗肿瘤免疫效应
Anna Morena D&#x;Alise,Nadia Brasu,Carlo De Intinis et al.
Anna Morena D&#x;Alise et al.
Upon chronic antigen exposure, CD8+ T cells become exhausted, acquiring a dysfunctional state correlated with the inability to control infection or tumor progression. In contrast, stem-like CD8+ T progenitors maintain the ability to promote...
Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques [0.03%]
恒河猴可轻松诱导针对冠状病毒的广谱中和抗体
Wan-Ting He,Meng Yuan,Sean Callaghan et al.
Wan-Ting He et al.
To prepare for future coronavirus (CoV) pandemics, it is desirable to generate vaccines capable of eliciting broadly neutralizing antibody responses to CoVs. Here, we show that immunization of macaques with SARS-CoV-2 spike (S) protein with...
Neuroblastoma suppressor of tumorigenicity 1 is a circulating protein associated with progression to end-stage kidney disease in diabetes [0.03%]
糖尿病患者神经母细胞瘤肿瘤抑制因子1与终末期肾病进展相关
Hiroki Kobayashi,Helen C Looker,Eiichiro Satake et al.
Hiroki Kobayashi et al.
Circulating proteins associated with transforming growth factor-β (TGF-β) signaling are implicated in the development of diabetic kidney disease (DKD). It remains to be comprehensively examined which of these proteins are involved in the ...
Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase [0.03%]
艾拉替尼通过靶向剪接体激酶选择性抑制刚地弓形虫和恶性疟原虫发育
Christopher Swale,Valeria Bellini,Matthew W Bowler et al.
Christopher Swale et al.
The Apicomplexa comprise a large phylum of single-celled, obligate intracellular protozoa that include Toxoplasma gondii, Plasmodium, and Cryptosporidium spp., which infect humans and animals and cause severe parasitic diseases. Available t...
Polysaccharide and conjugate vaccines to Streptococcus pneumoniae generate distinct humoral responses [0.03%]
肺炎链球菌多糖和结合疫苗产生不同的体液免疫反应
Leela R L Davies,Deniz Cizmeci,Wenyue Guo et al.
Leela R L Davies et al.
Streptococcus pneumoniae is a major cause of community-acquired pneumonia, bacteremia, and meningitis in older adults worldwide. Two pneumococcal vaccines containing S. pneumoniae capsular polysaccharides are in current use: the polysacchar...