Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases" [0.03%]
关于“小胶质细胞激活状态驱动神经退行性疾病的葡萄糖摄取和FDG-PET改变”的评论
Eduardo R Zimmer,Tharick A Pascoal,Pedro Rosa-Neto et al.
Eduardo R Zimmer et al.
Astrocytes might be the major contributor to the radioactive signal captured by PET in the microglia-dependent modulation of FDG-PET.
A genetically engineered Plasmodium falciparum parasite vaccine provides protection from controlled human malaria infection [0.03%]
一种遗传工程改造的恶性疟原虫疫苗可防止受控的人类疟疾感染
Sean C Murphy,Ashley M Vaughan,James G Kublin et al.
Sean C Murphy et al.
Genetically engineered live Plasmodium falciparum sporozoites constitute a potential platform for creating consistently attenuated, genetically defined, whole-parasite vaccines against malaria through targeted gene deletions. Such genetical...
Preclinical evaluation of proteolytic targeting of LCK as a therapeutic approach in T cell acute lymphoblastic leukemia [0.03%]
LCK蛋白酶靶向在T细胞急性淋巴细胞白血病治疗中的疗效的临床前评估研究
Jianzhong Hu,Jamie Jarusiewicz,Guoqing Du et al.
Jianzhong Hu et al.
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, and there is an unmet need for targeted therapies, especially for patients with relapsed disease. We have recently identified pre-T cell receptor and lym...
Intrinsic connectivity of the human brain provides scaffold for tau aggregation in clinical variants of Alzheimer's disease [0.03%]
人脑固有连接性为临床阿尔茨海默病变异体中的tau蛋白聚集提供了支架
Joseph Therriault,Tharick A Pascoal,Mélissa Savard et al.
Joseph Therriault et al.
Alzheimer's disease (AD) phenotypes might result from differences in selective vulnerability. Evidence from preclinical models suggests that tau pathology has cell-to-cell propagation properties. Therefore, here, we tested the cell-to-cell ...
Navigating regulatory pathways for translation of biologic cartilage repair products [0.03%]
生物性软骨修复产品监管路径的转化导航
Rachel C Nordberg,Gaston A Otarola,Dean Wang et al.
Rachel C Nordberg et al.
Long-term clinical repair of articular cartilage remains elusive despite advances in cartilage tissue engineering. Only one cartilage repair therapy classified as a "cellular and gene therapy product" has obtained Food and Drug Administrati...
Response to Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases" [0.03%]
对“小胶质细胞激活状态驱动神经退行性疾病中的葡萄糖摄取和FDG-PET改变”的评论回应
Xianyuan Xiang,Sabina Tahirovic,Sibylle Ziegler et al.
Xianyuan Xiang et al.
Microglial FDG uptake alterations are the source of FDG-PET changes in models of neurodegenerative diseases.
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease [0.03%]
广泛存在的细胞压力和线粒体功能障碍发生在早期阿尔茨海默病患者中
Ashwin V Venkataraman,Ayla Mansur,Gaia Rizzo et al.
Ashwin V Venkataraman et al.
Cell stress and impaired oxidative phosphorylation are central to mechanisms of synaptic loss and neurodegeneration in the cellular pathology of Alzheimer's disease (AD). In this study, we quantified the in vivo expression of the endoplasmi...
The systemic anti-microbiota IgG repertoire can identify gut bacteria that translocate across gut barrier surfaces [0.03%]
系统抗微生物IgG谱系可以识别穿过肠道屏障的细菌
Ivan Vujkovic-Cvijin,Hugh C Welles,Connie W Y Ha et al.
Ivan Vujkovic-Cvijin et al.
Unique gut microbiota compositions have been associated with inflammatory diseases, but identifying gut bacterial functions linked to immune activation in humans remains challenging. Translocation of pathogens from mucosal surfaces into per...
Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney [0.03%]
血管周围细胞中的鞘氨醇-1-磷酸信号通路增强肾脏炎症和纤维化
Shinji Tanaka,Shuqiu Zheng,Yugesh Kharel et al.
Shinji Tanaka et al.
Chronic kidney disease (CKD), characterized by sustained inflammation and progressive fibrosis, is highly prevalent and can eventually progress to end-stage kidney disease. However, current treatments to slow CKD progression are limited. Sp...
Temitayo O Idowu,Samir M Parikh
Temitayo O Idowu
The perivascular sphingosine 1-phosphate signaling axis may be an emerging therapeutic target for treating chronic kidney disease (Tanaka et al.).