Principles of gait encoding in the subthalamic nucleus of people with Parkinson's disease [0.03%]
帕金森病患者丘脑底核步态编码原理
Yohann Thenaisie,Kyuhwa Lee,Charlotte Moerman et al.
Yohann Thenaisie et al.
Disruption of subthalamic nucleus dynamics in Parkinson's disease leads to impairments during walking. Here, we aimed to uncover the principles through which the subthalamic nucleus encodes functional and dysfunctional walking in people wit...
Benjamin R Freedman,David J Mooney,Eckhard Weber
Benjamin R Freedman
Approved therapies for tendon diseases have not yet changed the clinical practice of symptomatic pain treatment and physiotherapy. This review article summarizes advances in the development of novel drugs, biologic products, and biomaterial...
Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation [0.03%]
缝隙连接蛋白通过促进FAK激活来调控乳腺癌向大脑的转移进展
Girieca Lorusso,Christof B Wyss,François Kuonen et al.
Girieca Lorusso et al.
Brain metastasis is a complication of increasing incidence in patients with breast cancer at advanced disease stage. It is a severe condition characterized by a rapid decline in quality of life and poor prognosis. There is a critical clinic...
Quantitative immunopeptidomics reveals a tumor stroma-specific target for T cell therapy [0.03%]
定量免疫肽组学发现肿瘤间质特异性T细胞治疗靶点
Gloria B Kim,Jens Fritsche,Sebastian Bunk et al.
Gloria B Kim et al.
T cell receptor (TCR)-based immunotherapy has emerged as a promising therapeutic approach for the treatment of patients with solid cancers. Identifying peptide-human leukocyte antigen (pHLA) complexes highly presented on tumors and rarely e...
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation [0.03%]
单细胞水平环境肠病表征揭示了上皮重塑和免疫激活的特征
Conner Kummerlowe,Simutanyi Mwakamui,Travis K Hughes et al.
Conner Kummerlowe et al.
Environmental enteropathy (EE) is a subclinical condition of the small intestine that is highly prevalent in low- and middle-income countries. It is thought to be a key contributing factor to childhood malnutrition, growth stunting, and dim...
Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer [0.03%]
表型药物筛选发现代谢GCH1/BH4途径是EGFR/KRAS介导的神经病理性疼痛和肺癌的关键调节因子
Shane J F Cronin,Shuan Rao,Miguel A Tejada et al.
Shane J F Cronin et al.
Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the de novo BH4 synthetic pathway, and human ...
Cardioprotective factors against myocardial infarction selected in vivo from an AAV secretome library [0.03%]
从AAV分泌组文库中筛选的心肌梗死心脏保护因子
Giulia Ruozi,Francesca Bortolotti,Antonio Mura et al.
Giulia Ruozi et al.
Therapies for patients with myocardial infarction and heart failure are urgently needed, in light of the breadth of these conditions and lack of curative treatments. To systematically identify previously unidentified cardioactive biological...
A targetable pathway in neutrophils mitigates both arterial and venous thrombosis [0.03%]
一条可靶向的途径通过减轻动脉和静脉血栓形成来抑制中性粒细胞的功能
Lalitha Nayak,David R Sweet,Asha Thomas et al.
Lalitha Nayak et al.
Arterial and venous thrombosis constitutes a major source of morbidity and mortality worldwide. Long considered as distinct entities, accumulating evidence indicates that arterial and venous thrombosis can occur in the same populations, sug...
Gut microbiome dysbiosis is associated with increased mortality after solid organ transplantation [0.03%]
肠道菌群失调与实体器官移植后死亡率增加有关
J Casper Swarte,Yanni Li,Shixian Hu et al.
J Casper Swarte et al.
Organ transplantation is a life-saving treatment for patients with end-stage disease, but survival rates after transplantation vary considerably. There is now increasing evidence that the gut microbiome is linked to the survival of patients...
Runliu Wu,Jiao Liu,Nian Wang et al.
Runliu Wu et al.
Sepsis is a challenging clinical syndrome caused by a dysregulated host response to infection. Here, we identified an unexpected proseptic activity of aconitate decarboxylase 1 (ACOD1) in monocytes and macrophages. Previous studies have sug...