A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections [0.03%]
治疗耐甲氧西林金黄色葡萄球菌生物被膜感染的新脂糖肽类抗生素奥利万星口服剂型的研发及应用进展
Mark A T Blaskovich,Karl A Hansford,Mark S Butler et al.
Mark A T Blaskovich et al.
Drug-resistant Gram-positive bacterial infections are still a substantial burden on the public health system, with two bacteria (Staphylococcus aureus and Streptococcus pneumoniae) accounting for over 1.5 million drug-resistant infections i...
Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor [0.03%]
低温诱导蛋白E1是LDL受体的转录后调节因子
Geoffrey A Smith,Arun Padmanabhan,Bryan H Lau et al.
Geoffrey A Smith et al.
The low-density lipoprotein receptor (LDLR) controls cellular delivery of cholesterol and clears LDL from the bloodstream, protecting against atherosclerotic heart disease, the leading cause of death in the United States. We therefore sough...
Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds [0.03%]
具有免疫调节作用的环氧泰利内化合物可诱导急性期和慢性期皮肤伤口生物膜解体并促进伤口愈合
Lydia C Powell,Jason K Cullen,Glen M Boyle et al.
Lydia C Powell et al.
The management of antibiotic-resistant, bacterial biofilm infections in chronic skin wounds is an increasing clinical challenge. Despite advances in diagnosis, many patients do not derive benefit from current anti-infective/antibiotic thera...
Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models [0.03%]
双刺突和核衣壳mRNA疫苗对预防SARS-CoV-2奥密克戎和德尔塔变异株具有保护作用：基于前期临床前模型的研究发现
Renee L Hajnik,Jessica A Plante,Yuejin Liang et al.
Renee L Hajnik et al.
Emergence of SARS-CoV-2 variants of concern (VOCs), including the highly transmissible Omicron and Delta strains, has posed constant challenges to the current COVID-19 vaccines that principally target the viral spike protein (S). Here, we r...
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins [0.03%]
多（腺苷二磷酸核糖）促进C9ORF72富含精氨酸的重复肽蛋白的毒性
Junli Gao,Quinlan T Mewborne,Amandeep Girdhar et al.
Junli Gao et al.
Arginine-rich dipeptide repeat proteins (R-DPRs), abnormal translational products of a GGGGCC hexanucleotide repeat expansion in C9ORF72, play a critical role in C9ORF72-related amyotrophic lateral sclerosis (ALS) and frontotemporal dementi...
A shift in lung macrophage composition is associated with COVID-19 severity and recovery [0.03%]
肺巨噬细胞组成的转变与COVID-19的严重性和恢复有关
Steven T Chen,Matthew D Park,Diane Marie Del Valle et al.
Steven T Chen et al.
Although it has been more than 2 years since the start of the coronavirus disease 2019 (COVID-19) pandemic, COVID-19 continues to be a worldwide health crisis. Despite the development of preventive vaccines, therapies to treat COVID-19 and ...
Retraction [0.03%]
撤稿通知
H Holden Thorp,Orla M Smith
H Holden Thorp
Retraction of Publication
Science translational medicine. 2022 Sep 7;14(661):eade6609. DOI:10.1126/scitranslmed.ade6609 2022
Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection [0.03%]
稳定的HIV-1包膜免疫诱导CD4结合位点的中和抗体并在恒河猴黏膜感染中起到保护作用
Kevin O Saunders,Robert J Edwards,Kedamawit Tilahun et al.
Kevin O Saunders et al.
A successful HIV-1 vaccine will require induction of a polyclonal neutralizing antibody (nAb) response, yet vaccine-mediated induction of such a response in primates remains a challenge. We found that a stabilized HIV-1 CH505 envelope (Env)...
Pharmacogenomic landscape of head and neck squamous cell carcinoma informs precision oncology therapy [0.03%]
头颈部鳞状细胞癌的药物基因组景观为精确肿瘤治疗提供信息
Ziyue Gu,Yanli Yao,Guizhu Yang et al.
Ziyue Gu et al.
Head and neck squamous cell carcinoma (HNSCC) is a common and frequently lethal cancer with few therapeutic options. In particular, there are few effective targeted therapies. Development of highly effective therapeutic strategies tailored ...
A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease [0.03%]
一种四价的TREM2激动型单克隆抗体可通过小鼠模型降低阿尔茨海默病淀粉样蛋白斑块病理表征
Peng Zhao,Yuanzhong Xu,LuLin Jiang et al.
Peng Zhao et al.
Triggering receptor expressed on myeloid cells 2 (TREM2) plays crucial roles in Alzheimer's disease (AD) by regulating microglia migration toward, and phagocytosis of oligomeric amyloid-β (oAβ) and amyloid plaques. Studies in rodent model...